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The association between XRCC1 Arg399Gln polymorphism and risk of leukemia in different populations: a meta-analysis of case-control studies.

Wang F, Zhao Q, He HR, Zhai YJ, Lu J, Hu HB, Zhou JS, Yang YH, Li YJ - Onco Targets Ther (2015)

Bottom Line: The XRCC1 Arg399Gln SNP was found to be associated with increased childhood risk of acute lymphoblastic leukemia among Asians under the dominant (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.50-2.97, P<0.0001), allele contrast (OR 1.72, 95% CI 1.33-2.23, P<0.0001), and homozygote contrast (OR 2.34, 95% CI 1.25-4.36, P=0.008) models.However, no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.The findings of the current meta-analysis indicate that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, People's Republic of China ; College of Pharmacy, Xi'an Medical University, Xi'an, People's Republic of China.

ABSTRACT

Background: Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods.

Methods: A meta-analysis was performed to examine the associations between XRCC1 Arg399-Gln SNP and leukemia risk. A literature search of PubMed and Web of Science databases was conducted to identify relevant studies published up to March 10, 2015. The references of the retrieved articles were also screened. All the statistical analyses were conducted using Review Manager software.

Results: The XRCC1 Arg399Gln SNP was found to be associated with increased childhood risk of acute lymphoblastic leukemia among Asians under the dominant (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.50-2.97, P<0.0001), allele contrast (OR 1.72, 95% CI 1.33-2.23, P<0.0001), and homozygote contrast (OR 2.34, 95% CI 1.25-4.36, P=0.008) models. However, no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.

Conclusion: The findings of the current meta-analysis indicate that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians.

No MeSH data available.


Related in: MedlinePlus

The funnel plots of meta-analysis for the association between XRCC1 Arg399Gln SNP and ALL risk under the recessive model (A), the dominant model (B), the allele contrast model (C), and the homozygote contrast model (D).Abbreviations: SNP, single-nucleotide polymorphism; ALL, acute lymphocytic leukemia; SE, standard error of the mean; OR, odds ratio.
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f3-ott-8-3277: The funnel plots of meta-analysis for the association between XRCC1 Arg399Gln SNP and ALL risk under the recessive model (A), the dominant model (B), the allele contrast model (C), and the homozygote contrast model (D).Abbreviations: SNP, single-nucleotide polymorphism; ALL, acute lymphocytic leukemia; SE, standard error of the mean; OR, odds ratio.

Mentions: The forest plot revealed no heterogeneity under the recessive (P=0.65, I2=0%) and homozygote contrast (P=0.50, I2=0%) models, and I2<50% under the allele contrast (P=0.05, I2=46%) model. The fixed-effects model was therefore used for these three contrast models. The degree of heterogeneity was high (I2=62%, P=0.003) under the dominant model; therefore, a random-effects model was employed under that model. Finally, an association was found between the SNP and increased childhood ALL risk under the allele contrast (OR 1.21, 95% CI 1.06–1.37, P=0.003) and homozygote contrast (OR 1.41, 95% CI 1.06–1.88, P=0.02) models. The funnel plot did not reveal any obvious publication bias (Figure 3).


The association between XRCC1 Arg399Gln polymorphism and risk of leukemia in different populations: a meta-analysis of case-control studies.

Wang F, Zhao Q, He HR, Zhai YJ, Lu J, Hu HB, Zhou JS, Yang YH, Li YJ - Onco Targets Ther (2015)

The funnel plots of meta-analysis for the association between XRCC1 Arg399Gln SNP and ALL risk under the recessive model (A), the dominant model (B), the allele contrast model (C), and the homozygote contrast model (D).Abbreviations: SNP, single-nucleotide polymorphism; ALL, acute lymphocytic leukemia; SE, standard error of the mean; OR, odds ratio.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644162&req=5

f3-ott-8-3277: The funnel plots of meta-analysis for the association between XRCC1 Arg399Gln SNP and ALL risk under the recessive model (A), the dominant model (B), the allele contrast model (C), and the homozygote contrast model (D).Abbreviations: SNP, single-nucleotide polymorphism; ALL, acute lymphocytic leukemia; SE, standard error of the mean; OR, odds ratio.
Mentions: The forest plot revealed no heterogeneity under the recessive (P=0.65, I2=0%) and homozygote contrast (P=0.50, I2=0%) models, and I2<50% under the allele contrast (P=0.05, I2=46%) model. The fixed-effects model was therefore used for these three contrast models. The degree of heterogeneity was high (I2=62%, P=0.003) under the dominant model; therefore, a random-effects model was employed under that model. Finally, an association was found between the SNP and increased childhood ALL risk under the allele contrast (OR 1.21, 95% CI 1.06–1.37, P=0.003) and homozygote contrast (OR 1.41, 95% CI 1.06–1.88, P=0.02) models. The funnel plot did not reveal any obvious publication bias (Figure 3).

Bottom Line: The XRCC1 Arg399Gln SNP was found to be associated with increased childhood risk of acute lymphoblastic leukemia among Asians under the dominant (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.50-2.97, P<0.0001), allele contrast (OR 1.72, 95% CI 1.33-2.23, P<0.0001), and homozygote contrast (OR 2.34, 95% CI 1.25-4.36, P=0.008) models.However, no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.The findings of the current meta-analysis indicate that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, People's Republic of China ; College of Pharmacy, Xi'an Medical University, Xi'an, People's Republic of China.

ABSTRACT

Background: Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods.

Methods: A meta-analysis was performed to examine the associations between XRCC1 Arg399-Gln SNP and leukemia risk. A literature search of PubMed and Web of Science databases was conducted to identify relevant studies published up to March 10, 2015. The references of the retrieved articles were also screened. All the statistical analyses were conducted using Review Manager software.

Results: The XRCC1 Arg399Gln SNP was found to be associated with increased childhood risk of acute lymphoblastic leukemia among Asians under the dominant (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.50-2.97, P<0.0001), allele contrast (OR 1.72, 95% CI 1.33-2.23, P<0.0001), and homozygote contrast (OR 2.34, 95% CI 1.25-4.36, P=0.008) models. However, no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.

Conclusion: The findings of the current meta-analysis indicate that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians.

No MeSH data available.


Related in: MedlinePlus