Limits...
The association between XRCC1 Arg399Gln polymorphism and risk of leukemia in different populations: a meta-analysis of case-control studies.

Wang F, Zhao Q, He HR, Zhai YJ, Lu J, Hu HB, Zhou JS, Yang YH, Li YJ - Onco Targets Ther (2015)

Bottom Line: The XRCC1 Arg399Gln SNP was found to be associated with increased childhood risk of acute lymphoblastic leukemia among Asians under the dominant (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.50-2.97, P<0.0001), allele contrast (OR 1.72, 95% CI 1.33-2.23, P<0.0001), and homozygote contrast (OR 2.34, 95% CI 1.25-4.36, P=0.008) models.However, no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.The findings of the current meta-analysis indicate that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, People's Republic of China ; College of Pharmacy, Xi'an Medical University, Xi'an, People's Republic of China.

ABSTRACT

Background: Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods.

Methods: A meta-analysis was performed to examine the associations between XRCC1 Arg399-Gln SNP and leukemia risk. A literature search of PubMed and Web of Science databases was conducted to identify relevant studies published up to March 10, 2015. The references of the retrieved articles were also screened. All the statistical analyses were conducted using Review Manager software.

Results: The XRCC1 Arg399Gln SNP was found to be associated with increased childhood risk of acute lymphoblastic leukemia among Asians under the dominant (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.50-2.97, P<0.0001), allele contrast (OR 1.72, 95% CI 1.33-2.23, P<0.0001), and homozygote contrast (OR 2.34, 95% CI 1.25-4.36, P=0.008) models. However, no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.

Conclusion: The findings of the current meta-analysis indicate that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians.

No MeSH data available.


Related in: MedlinePlus

Meta-analysis of the association between XRCC1 Arg399Gln SNP and AML risk under the allele contrast model (A), the homozygote contrast model (B), the recessive model (C), and the dominant model (D).Abbreviations: SNP, single-nucleotide polymorphism; AML, acute myeloid leukemia; CI, confidence interval; M–H, Mantel–Haenszel.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4644162&req=5

f2-ott-8-3277: Meta-analysis of the association between XRCC1 Arg399Gln SNP and AML risk under the allele contrast model (A), the homozygote contrast model (B), the recessive model (C), and the dominant model (D).Abbreviations: SNP, single-nucleotide polymorphism; AML, acute myeloid leukemia; CI, confidence interval; M–H, Mantel–Haenszel.

Mentions: In view of the high degree of heterogeneity, a sensitivity analysis was conducted, and the study by Banescu et al9 was found to be an outlier. Removal of their data from the analysis reduced the degree of heterogeneity under the recessive and dominant models, but not sufficiently so under the allele contrast (I2=65%, P=0.06; Figure 2A) and homozygote contrast models (I2=59%, P=0.09; Figure 2B). Fixed-effects modeling was thus performed for the recessive and dominant models, and finally, the SNP was associated with AML risk under the recessive model (OR 0.58, 95% CI 0.38–0.89, P=0.01; Figure 2C) but not under the dominant model (OR 0.79, 95% CI 0.58–1.07, P=0.13; Figure 2D). Therefore, the result for AML under the recessive model is sensitive to the study by Banescu et al.9


The association between XRCC1 Arg399Gln polymorphism and risk of leukemia in different populations: a meta-analysis of case-control studies.

Wang F, Zhao Q, He HR, Zhai YJ, Lu J, Hu HB, Zhou JS, Yang YH, Li YJ - Onco Targets Ther (2015)

Meta-analysis of the association between XRCC1 Arg399Gln SNP and AML risk under the allele contrast model (A), the homozygote contrast model (B), the recessive model (C), and the dominant model (D).Abbreviations: SNP, single-nucleotide polymorphism; AML, acute myeloid leukemia; CI, confidence interval; M–H, Mantel–Haenszel.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644162&req=5

f2-ott-8-3277: Meta-analysis of the association between XRCC1 Arg399Gln SNP and AML risk under the allele contrast model (A), the homozygote contrast model (B), the recessive model (C), and the dominant model (D).Abbreviations: SNP, single-nucleotide polymorphism; AML, acute myeloid leukemia; CI, confidence interval; M–H, Mantel–Haenszel.
Mentions: In view of the high degree of heterogeneity, a sensitivity analysis was conducted, and the study by Banescu et al9 was found to be an outlier. Removal of their data from the analysis reduced the degree of heterogeneity under the recessive and dominant models, but not sufficiently so under the allele contrast (I2=65%, P=0.06; Figure 2A) and homozygote contrast models (I2=59%, P=0.09; Figure 2B). Fixed-effects modeling was thus performed for the recessive and dominant models, and finally, the SNP was associated with AML risk under the recessive model (OR 0.58, 95% CI 0.38–0.89, P=0.01; Figure 2C) but not under the dominant model (OR 0.79, 95% CI 0.58–1.07, P=0.13; Figure 2D). Therefore, the result for AML under the recessive model is sensitive to the study by Banescu et al.9

Bottom Line: The XRCC1 Arg399Gln SNP was found to be associated with increased childhood risk of acute lymphoblastic leukemia among Asians under the dominant (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.50-2.97, P<0.0001), allele contrast (OR 1.72, 95% CI 1.33-2.23, P<0.0001), and homozygote contrast (OR 2.34, 95% CI 1.25-4.36, P=0.008) models.However, no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.The findings of the current meta-analysis indicate that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, People's Republic of China ; College of Pharmacy, Xi'an Medical University, Xi'an, People's Republic of China.

ABSTRACT

Background: Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods.

Methods: A meta-analysis was performed to examine the associations between XRCC1 Arg399-Gln SNP and leukemia risk. A literature search of PubMed and Web of Science databases was conducted to identify relevant studies published up to March 10, 2015. The references of the retrieved articles were also screened. All the statistical analyses were conducted using Review Manager software.

Results: The XRCC1 Arg399Gln SNP was found to be associated with increased childhood risk of acute lymphoblastic leukemia among Asians under the dominant (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.50-2.97, P<0.0001), allele contrast (OR 1.72, 95% CI 1.33-2.23, P<0.0001), and homozygote contrast (OR 2.34, 95% CI 1.25-4.36, P=0.008) models. However, no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.

Conclusion: The findings of the current meta-analysis indicate that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians.

No MeSH data available.


Related in: MedlinePlus