Limits...
Overexpression of miR-210 is Associated with Poor Prognosis of Acute Myeloid Leukemia.

Tang X, Chen L, Yan X, Li Y, Xiong Y, Zhou X - Med. Sci. Monit. (2015)

Bottom Line: The serum miR-210 expression level was reduced significantly when the patients achieved complete remission (p=0.02).In the multivariate analysis model, miR-210 was identified as an independent prognostic marker.MiR-210 up-regulation was associated with poor prognosis in AML and it might be useful as a marker for predicting the clinical outcome of AML patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (mainland).

ABSTRACT

Background: MicroRNAs play important roles in regulation of the initiation and progression of AML. MiR-210 is closely related with cancer development; however, whether miR-210 expression level correlates with clinical correlation in AML is unknown. Thus, the aim of this study was to investigate the potential relationship between miR-210 expression and AML prognosis.

Material and methods: Real-time quantitative PCR was carried out to examine the expression level of miR-210 in bone marrow and serum obtained from AML patients and healthy controls. Then the correlation between miR-210 expression and a variety of important clinical parameters (such as overall survival, relapse-free survival, and prognostic value) were further studied.

Results: The expression level of miR-210 was significantly higher in the bone marrow and serum of AML patients than that of healthy controls (p<0.001). Moreover, miR-210 expression was associated with various AML clinicopathological parameters, including FAB classification and cytogenetics. The serum miR-210 expression level was reduced significantly when the patients achieved complete remission (p=0.02). The high miR-210 expression group had both poorer relapse-free survival (p=0.015) and worse overall survival (p=0.008). In the multivariate analysis model, miR-210 was identified as an independent prognostic marker.

Conclusions: MiR-210 up-regulation was associated with poor prognosis in AML and it might be useful as a marker for predicting the clinical outcome of AML patients.

Show MeSH

Related in: MedlinePlus

The association between serum miR-210 expression level and treatment response.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4644019&req=5

f2-medscimonit-21-3427: The association between serum miR-210 expression level and treatment response.

Mentions: We compared the expression level of serum miR-210 in AML patients (the high miR-210 expression group) before or after achieving a complete remission. The results showed that the serum miR-210 expression level was reduced significantly when the AML patients achieved a complete remission (p=0.02), indicating that serum miR-210 expression is strongly correlated with treatment response (Figure 2).


Overexpression of miR-210 is Associated with Poor Prognosis of Acute Myeloid Leukemia.

Tang X, Chen L, Yan X, Li Y, Xiong Y, Zhou X - Med. Sci. Monit. (2015)

The association between serum miR-210 expression level and treatment response.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4644019&req=5

f2-medscimonit-21-3427: The association between serum miR-210 expression level and treatment response.
Mentions: We compared the expression level of serum miR-210 in AML patients (the high miR-210 expression group) before or after achieving a complete remission. The results showed that the serum miR-210 expression level was reduced significantly when the AML patients achieved a complete remission (p=0.02), indicating that serum miR-210 expression is strongly correlated with treatment response (Figure 2).

Bottom Line: The serum miR-210 expression level was reduced significantly when the patients achieved complete remission (p=0.02).In the multivariate analysis model, miR-210 was identified as an independent prognostic marker.MiR-210 up-regulation was associated with poor prognosis in AML and it might be useful as a marker for predicting the clinical outcome of AML patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (mainland).

ABSTRACT

Background: MicroRNAs play important roles in regulation of the initiation and progression of AML. MiR-210 is closely related with cancer development; however, whether miR-210 expression level correlates with clinical correlation in AML is unknown. Thus, the aim of this study was to investigate the potential relationship between miR-210 expression and AML prognosis.

Material and methods: Real-time quantitative PCR was carried out to examine the expression level of miR-210 in bone marrow and serum obtained from AML patients and healthy controls. Then the correlation between miR-210 expression and a variety of important clinical parameters (such as overall survival, relapse-free survival, and prognostic value) were further studied.

Results: The expression level of miR-210 was significantly higher in the bone marrow and serum of AML patients than that of healthy controls (p<0.001). Moreover, miR-210 expression was associated with various AML clinicopathological parameters, including FAB classification and cytogenetics. The serum miR-210 expression level was reduced significantly when the patients achieved complete remission (p=0.02). The high miR-210 expression group had both poorer relapse-free survival (p=0.015) and worse overall survival (p=0.008). In the multivariate analysis model, miR-210 was identified as an independent prognostic marker.

Conclusions: MiR-210 up-regulation was associated with poor prognosis in AML and it might be useful as a marker for predicting the clinical outcome of AML patients.

Show MeSH
Related in: MedlinePlus