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DBGC: A Database of Human Gastric Cancer.

Wang C, Zhang J, Cai M, Zhu Z, Gu W, Yu Y, Zhang X - PLoS ONE (2015)

Bottom Line: The Database of Human Gastric Cancer (DBGC) is a comprehensive database that integrates various human gastric cancer-related data resources.Moreover, epidemiological statistics of gastric cancer patients in China and clinicopathological information annotated with gastric cancer cases were also integrated into the DBGC.We believe that this database will greatly facilitate research regarding human gastric cancer in many fields.

View Article: PubMed Central - PubMed

Affiliation: School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai, China.

ABSTRACT
The Database of Human Gastric Cancer (DBGC) is a comprehensive database that integrates various human gastric cancer-related data resources. Human gastric cancer-related transcriptomics projects, proteomics projects, mutations, biomarkers and drug-sensitive genes from different sources were collected and unified in this database. Moreover, epidemiological statistics of gastric cancer patients in China and clinicopathological information annotated with gastric cancer cases were also integrated into the DBGC. We believe that this database will greatly facilitate research regarding human gastric cancer in many fields. DBGC is freely available at http://bminfor.tongji.edu.cn/dbgc/index.do.

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pone.0142591.g002: Quick search function module.

Mentions: 1) Quick Search (Fig 2). The quick search function module makes identifying the role of a gene or protein in gastric cancer possible via inputting keywords into the search box located at the navigation bar. The search result will tell you whether the gene or protein is differentially expressed in any transcriptomics projects or proteomics projects and whether it has been identified as a biomarker for gastric cancer or a drug-sensitive gene. Moreover, if the gene has any mutation that is related to gastric cancer, a detailed list will be displayed on the results page. For example, using “EGFR” as a keyword, we can conclude that it was identified as an up-regulated gene in GSE51936 and GSE27342 and as a down-regulated gene in GSE29630. The corresponding protein of the gene EGFR was identified as an up-regulated protein in 3 proteomics projects (PubMed Ids: 23161554, 24263233 and 24722433). EGFR has been reported as a prognosis factor of gastric cancer and is related to drug resistance to irinotecan, which is a commonly used drug for the treatment of gastric cancer. Four mutations of EGFR related to gastric cancer have been reported (c.2361G>A, c.2402A>G, c.2573T>G, c.2588G>A).


DBGC: A Database of Human Gastric Cancer.

Wang C, Zhang J, Cai M, Zhu Z, Gu W, Yu Y, Zhang X - PLoS ONE (2015)

Quick search function module.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4643992&req=5

pone.0142591.g002: Quick search function module.
Mentions: 1) Quick Search (Fig 2). The quick search function module makes identifying the role of a gene or protein in gastric cancer possible via inputting keywords into the search box located at the navigation bar. The search result will tell you whether the gene or protein is differentially expressed in any transcriptomics projects or proteomics projects and whether it has been identified as a biomarker for gastric cancer or a drug-sensitive gene. Moreover, if the gene has any mutation that is related to gastric cancer, a detailed list will be displayed on the results page. For example, using “EGFR” as a keyword, we can conclude that it was identified as an up-regulated gene in GSE51936 and GSE27342 and as a down-regulated gene in GSE29630. The corresponding protein of the gene EGFR was identified as an up-regulated protein in 3 proteomics projects (PubMed Ids: 23161554, 24263233 and 24722433). EGFR has been reported as a prognosis factor of gastric cancer and is related to drug resistance to irinotecan, which is a commonly used drug for the treatment of gastric cancer. Four mutations of EGFR related to gastric cancer have been reported (c.2361G>A, c.2402A>G, c.2573T>G, c.2588G>A).

Bottom Line: The Database of Human Gastric Cancer (DBGC) is a comprehensive database that integrates various human gastric cancer-related data resources.Moreover, epidemiological statistics of gastric cancer patients in China and clinicopathological information annotated with gastric cancer cases were also integrated into the DBGC.We believe that this database will greatly facilitate research regarding human gastric cancer in many fields.

View Article: PubMed Central - PubMed

Affiliation: School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai, China.

ABSTRACT
The Database of Human Gastric Cancer (DBGC) is a comprehensive database that integrates various human gastric cancer-related data resources. Human gastric cancer-related transcriptomics projects, proteomics projects, mutations, biomarkers and drug-sensitive genes from different sources were collected and unified in this database. Moreover, epidemiological statistics of gastric cancer patients in China and clinicopathological information annotated with gastric cancer cases were also integrated into the DBGC. We believe that this database will greatly facilitate research regarding human gastric cancer in many fields. DBGC is freely available at http://bminfor.tongji.edu.cn/dbgc/index.do.

Show MeSH
Related in: MedlinePlus