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Association of Big Endothelin-1 with Coronary Artery Calcification.

Qing P, Li XL, Zhang Y, Li YL, Xu RX, Guo YL, Li S, Wu NQ, Li JJ - PLoS ONE (2015)

Bottom Line: All patients had received coronary computed tomography angiography and then divided into two groups based on the results of coronary artery calcium score (CACS).Patients with CAC had significantly elevated big ET-1 level compared with those without CAC (0.5 ± 0.4 vs. 0.2 ± 0.2, P<0.001).The data firstly demonstrated that the plasma big ET-1 level was a valuable independent predictor for CAC in our study.

View Article: PubMed Central - PubMed

Affiliation: Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Bei Li Shi Road 167, Beijing, 100037, China.

ABSTRACT

Background: The coronary artery calcification (CAC) is clinically considered as one of the important predictors of atherosclerosis. Several studies have confirmed that endothelin-1(ET-1) plays an important role in the process of atherosclerosis formation. The aim of this study was to investigate whether big ET-1 is associated with CAC.

Methods and results: A total of 510 consecutively admitted patients from February 2011 to May 2012 in Fu Wai Hospital were analyzed. All patients had received coronary computed tomography angiography and then divided into two groups based on the results of coronary artery calcium score (CACS). The clinical characteristics including traditional and calcification-related risk factors were collected and plasma big ET-1 level was measured by ELISA. Patients with CAC had significantly elevated big ET-1 level compared with those without CAC (0.5 ± 0.4 vs. 0.2 ± 0.2, P<0.001). In the multivariate analysis, big ET-1 (Tertile 2, HR = 3.09, 95% CI 1.66-5.74, P <0.001, Tertile3 HR = 10.42, 95% CI 3.62-29.99, P<0.001) appeared as an independent predictive factor of the presence of CAC. There was a positive correlation of the big ET-1 level with CACS (r = 0.567, p<0.001). The 10-year Framingham risk (%) was higher in the group with CACS>0 and the highest tertile of big ET-1 (P<0.01). The area under the receiver operating characteristic curve for the big ET-1 level in predicting CAC was 0.83 (95% CI 0.79-0.87, p<0.001), with a sensitivity of 70.6% and specificity of 87.7%.

Conclusions: The data firstly demonstrated that the plasma big ET-1 level was a valuable independent predictor for CAC in our study.

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The 10-year Framingham risk in 3 subgroups of patients.The risk is lower in individuals with both CACS = 0 and Tertile 1 of Big ET-1. Group A: CACS = 0 and Tertile 1 of Big ET-1; Group C: CACS >0 and Tertile 3 of Big ET-1; Group B: Others.
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pone.0142458.g003: The 10-year Framingham risk in 3 subgroups of patients.The risk is lower in individuals with both CACS = 0 and Tertile 1 of Big ET-1. Group A: CACS = 0 and Tertile 1 of Big ET-1; Group C: CACS >0 and Tertile 3 of Big ET-1; Group B: Others.

Mentions: To evaluate the value of the 10-year Framingham risk using combination of big ET-1 and CAC in our study, patients were divided into three subgroups according to plasma big ET-1 levels and CAC. Group A (n = 103): CACS = 0 and the levels of big ET-1 in Tertile 1; Group C (n = 163): CACS>0 and the levels of big ET-1 in Tertile 3; Group B (n = 244): the participants who were not in Group A and in Group C. Comparison within the groups by Bonferroni post hoc analysis showed the combintion of big ET-1 and CAC was a significant predictor for the 10-year Framingham risk. The 10-year Framingham risk (%) was 6.9±6.2 in group A, 10.5±8.0 in group B and 13.0±11.7 in group C (P<0.001, Fig 3; Group A vs. B, Group A vs. C, Group B vs. Group C, all P<0.001, S2 Table).


Association of Big Endothelin-1 with Coronary Artery Calcification.

Qing P, Li XL, Zhang Y, Li YL, Xu RX, Guo YL, Li S, Wu NQ, Li JJ - PLoS ONE (2015)

The 10-year Framingham risk in 3 subgroups of patients.The risk is lower in individuals with both CACS = 0 and Tertile 1 of Big ET-1. Group A: CACS = 0 and Tertile 1 of Big ET-1; Group C: CACS >0 and Tertile 3 of Big ET-1; Group B: Others.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4643989&req=5

pone.0142458.g003: The 10-year Framingham risk in 3 subgroups of patients.The risk is lower in individuals with both CACS = 0 and Tertile 1 of Big ET-1. Group A: CACS = 0 and Tertile 1 of Big ET-1; Group C: CACS >0 and Tertile 3 of Big ET-1; Group B: Others.
Mentions: To evaluate the value of the 10-year Framingham risk using combination of big ET-1 and CAC in our study, patients were divided into three subgroups according to plasma big ET-1 levels and CAC. Group A (n = 103): CACS = 0 and the levels of big ET-1 in Tertile 1; Group C (n = 163): CACS>0 and the levels of big ET-1 in Tertile 3; Group B (n = 244): the participants who were not in Group A and in Group C. Comparison within the groups by Bonferroni post hoc analysis showed the combintion of big ET-1 and CAC was a significant predictor for the 10-year Framingham risk. The 10-year Framingham risk (%) was 6.9±6.2 in group A, 10.5±8.0 in group B and 13.0±11.7 in group C (P<0.001, Fig 3; Group A vs. B, Group A vs. C, Group B vs. Group C, all P<0.001, S2 Table).

Bottom Line: All patients had received coronary computed tomography angiography and then divided into two groups based on the results of coronary artery calcium score (CACS).Patients with CAC had significantly elevated big ET-1 level compared with those without CAC (0.5 ± 0.4 vs. 0.2 ± 0.2, P<0.001).The data firstly demonstrated that the plasma big ET-1 level was a valuable independent predictor for CAC in our study.

View Article: PubMed Central - PubMed

Affiliation: Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Bei Li Shi Road 167, Beijing, 100037, China.

ABSTRACT

Background: The coronary artery calcification (CAC) is clinically considered as one of the important predictors of atherosclerosis. Several studies have confirmed that endothelin-1(ET-1) plays an important role in the process of atherosclerosis formation. The aim of this study was to investigate whether big ET-1 is associated with CAC.

Methods and results: A total of 510 consecutively admitted patients from February 2011 to May 2012 in Fu Wai Hospital were analyzed. All patients had received coronary computed tomography angiography and then divided into two groups based on the results of coronary artery calcium score (CACS). The clinical characteristics including traditional and calcification-related risk factors were collected and plasma big ET-1 level was measured by ELISA. Patients with CAC had significantly elevated big ET-1 level compared with those without CAC (0.5 ± 0.4 vs. 0.2 ± 0.2, P<0.001). In the multivariate analysis, big ET-1 (Tertile 2, HR = 3.09, 95% CI 1.66-5.74, P <0.001, Tertile3 HR = 10.42, 95% CI 3.62-29.99, P<0.001) appeared as an independent predictive factor of the presence of CAC. There was a positive correlation of the big ET-1 level with CACS (r = 0.567, p<0.001). The 10-year Framingham risk (%) was higher in the group with CACS>0 and the highest tertile of big ET-1 (P<0.01). The area under the receiver operating characteristic curve for the big ET-1 level in predicting CAC was 0.83 (95% CI 0.79-0.87, p<0.001), with a sensitivity of 70.6% and specificity of 87.7%.

Conclusions: The data firstly demonstrated that the plasma big ET-1 level was a valuable independent predictor for CAC in our study.

Show MeSH
Related in: MedlinePlus