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Association of Big Endothelin-1 with Coronary Artery Calcification.

Qing P, Li XL, Zhang Y, Li YL, Xu RX, Guo YL, Li S, Wu NQ, Li JJ - PLoS ONE (2015)

Bottom Line: All patients had received coronary computed tomography angiography and then divided into two groups based on the results of coronary artery calcium score (CACS).Patients with CAC had significantly elevated big ET-1 level compared with those without CAC (0.5 ± 0.4 vs. 0.2 ± 0.2, P<0.001).The data firstly demonstrated that the plasma big ET-1 level was a valuable independent predictor for CAC in our study.

View Article: PubMed Central - PubMed

Affiliation: Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Bei Li Shi Road 167, Beijing, 100037, China.

ABSTRACT

Background: The coronary artery calcification (CAC) is clinically considered as one of the important predictors of atherosclerosis. Several studies have confirmed that endothelin-1(ET-1) plays an important role in the process of atherosclerosis formation. The aim of this study was to investigate whether big ET-1 is associated with CAC.

Methods and results: A total of 510 consecutively admitted patients from February 2011 to May 2012 in Fu Wai Hospital were analyzed. All patients had received coronary computed tomography angiography and then divided into two groups based on the results of coronary artery calcium score (CACS). The clinical characteristics including traditional and calcification-related risk factors were collected and plasma big ET-1 level was measured by ELISA. Patients with CAC had significantly elevated big ET-1 level compared with those without CAC (0.5 ± 0.4 vs. 0.2 ± 0.2, P<0.001). In the multivariate analysis, big ET-1 (Tertile 2, HR = 3.09, 95% CI 1.66-5.74, P <0.001, Tertile3 HR = 10.42, 95% CI 3.62-29.99, P<0.001) appeared as an independent predictive factor of the presence of CAC. There was a positive correlation of the big ET-1 level with CACS (r = 0.567, p<0.001). The 10-year Framingham risk (%) was higher in the group with CACS>0 and the highest tertile of big ET-1 (P<0.01). The area under the receiver operating characteristic curve for the big ET-1 level in predicting CAC was 0.83 (95% CI 0.79-0.87, p<0.001), with a sensitivity of 70.6% and specificity of 87.7%.

Conclusions: The data firstly demonstrated that the plasma big ET-1 level was a valuable independent predictor for CAC in our study.

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ROC curves for the Big ET-1 and HbA1c.ROC curves showed discriminatory power of baseline Big ET-1 and HbA1c on population with CAC.
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pone.0142458.g002: ROC curves for the Big ET-1 and HbA1c.ROC curves showed discriminatory power of baseline Big ET-1 and HbA1c on population with CAC.

Mentions: Area under the receivers operating characteristic (ROC) curves (Fig 2 and Table 4) suggested that big ET-1, beyond lipid parameters and nonspecific inflammatory biomarkers, was a significant predictor for patients with CAC (AUC = 0.83, 95% CI 0.79–0.87, P<0.001). The optimal cutoff value for the plasma big ET-1 level for predicting CAC was 0.30 pmol/L, with a sensitivity of 70.6% and specificity of 87.7%.


Association of Big Endothelin-1 with Coronary Artery Calcification.

Qing P, Li XL, Zhang Y, Li YL, Xu RX, Guo YL, Li S, Wu NQ, Li JJ - PLoS ONE (2015)

ROC curves for the Big ET-1 and HbA1c.ROC curves showed discriminatory power of baseline Big ET-1 and HbA1c on population with CAC.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4643989&req=5

pone.0142458.g002: ROC curves for the Big ET-1 and HbA1c.ROC curves showed discriminatory power of baseline Big ET-1 and HbA1c on population with CAC.
Mentions: Area under the receivers operating characteristic (ROC) curves (Fig 2 and Table 4) suggested that big ET-1, beyond lipid parameters and nonspecific inflammatory biomarkers, was a significant predictor for patients with CAC (AUC = 0.83, 95% CI 0.79–0.87, P<0.001). The optimal cutoff value for the plasma big ET-1 level for predicting CAC was 0.30 pmol/L, with a sensitivity of 70.6% and specificity of 87.7%.

Bottom Line: All patients had received coronary computed tomography angiography and then divided into two groups based on the results of coronary artery calcium score (CACS).Patients with CAC had significantly elevated big ET-1 level compared with those without CAC (0.5 ± 0.4 vs. 0.2 ± 0.2, P<0.001).The data firstly demonstrated that the plasma big ET-1 level was a valuable independent predictor for CAC in our study.

View Article: PubMed Central - PubMed

Affiliation: Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Bei Li Shi Road 167, Beijing, 100037, China.

ABSTRACT

Background: The coronary artery calcification (CAC) is clinically considered as one of the important predictors of atherosclerosis. Several studies have confirmed that endothelin-1(ET-1) plays an important role in the process of atherosclerosis formation. The aim of this study was to investigate whether big ET-1 is associated with CAC.

Methods and results: A total of 510 consecutively admitted patients from February 2011 to May 2012 in Fu Wai Hospital were analyzed. All patients had received coronary computed tomography angiography and then divided into two groups based on the results of coronary artery calcium score (CACS). The clinical characteristics including traditional and calcification-related risk factors were collected and plasma big ET-1 level was measured by ELISA. Patients with CAC had significantly elevated big ET-1 level compared with those without CAC (0.5 ± 0.4 vs. 0.2 ± 0.2, P<0.001). In the multivariate analysis, big ET-1 (Tertile 2, HR = 3.09, 95% CI 1.66-5.74, P <0.001, Tertile3 HR = 10.42, 95% CI 3.62-29.99, P<0.001) appeared as an independent predictive factor of the presence of CAC. There was a positive correlation of the big ET-1 level with CACS (r = 0.567, p<0.001). The 10-year Framingham risk (%) was higher in the group with CACS>0 and the highest tertile of big ET-1 (P<0.01). The area under the receiver operating characteristic curve for the big ET-1 level in predicting CAC was 0.83 (95% CI 0.79-0.87, p<0.001), with a sensitivity of 70.6% and specificity of 87.7%.

Conclusions: The data firstly demonstrated that the plasma big ET-1 level was a valuable independent predictor for CAC in our study.

Show MeSH
Related in: MedlinePlus