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Detection and Characterization of Metastatic Cancer Cells in the Mesogastrium of Gastric Cancer Patients.

Xie D, Liu L, Osaiweran H, Yu C, Sheng F, Gao C, Hu J, Gong J - PLoS ONE (2015)

Bottom Line: Gastric cancer is the second leading cause of cancer death worldwide.Metastasis V was closely associated with tumor invasion depth, along with a number of positive lymph node metastasis.The prognosis of patients with Metastasis V was significantly (P<0.05) worse than those with tumor cell-free mesogastrium.

View Article: PubMed Central - PubMed

Affiliation: Tongji Cancer Research Institute, Tongji Hospital, Tongji Medical College in Huazhong University of Science and Technology, Wuhan, Hubei, China.

ABSTRACT
Gastric cancer is the second leading cause of cancer death worldwide. Here, we propose a novel type of tumor metastasis designated as Metastasis V in gastric cancer. Metastasis V is defined as the appearance of cancer cells in the mesogastrium with perigastric adipose tissue. To detect its incidence and characterize its clinic pathological features, large cross sectional tissue analysis of mesogastrium from 74 patients were used. Metastasis V was detected in 1 of 40 (2.5%) patients with early gastric cancer, 8 of 34 (24%) patients with advanced gastric cancer. The mean distance of Metastasis V from gastric wall was approximately 2.6 cm. Metastasis V was closely associated with tumor invasion depth, along with a number of positive lymph node metastasis. The prognosis of patients with Metastasis V was significantly (P<0.05) worse than those with tumor cell-free mesogastrium. These findings indicate that by using whole-sectional analysis, Metastasis V can be detected in the mesogastrium of gastric cancer patients, and also suggests that it may be a risk factor for patient survival after radical surgery.

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The overall survival of patients with or without Metastasis V.(A) The Kaplan–Meier overall survival curves showed the prognosis of Metastasis V-positive patients was significantly (P = 0.006) worse than Metastasis V-negative patients. (B-C) Metastasis V-positive patients had a significantly poorer prognosis than Metastasis V-negative patients in the T3 subgroup (P = 0.004; B) or in clinical stage III (P = 0.0005; C).
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pone.0142970.g003: The overall survival of patients with or without Metastasis V.(A) The Kaplan–Meier overall survival curves showed the prognosis of Metastasis V-positive patients was significantly (P = 0.006) worse than Metastasis V-negative patients. (B-C) Metastasis V-positive patients had a significantly poorer prognosis than Metastasis V-negative patients in the T3 subgroup (P = 0.004; B) or in clinical stage III (P = 0.0005; C).

Mentions: Based on our follow-up data, the prognosis of all Metastasis V-positive patients was significantly (P = 0.006) worse than Metastasis V-negative patients (Fig 3A). In addition, we analysed the prognostic significance of Metastasis V in the different tumor subgroups (T2, T3 and T4) or clinical stages (II and III). The prognosis of the patients with Metastasis V-positive was significantly poorer than those with Metastasis V-negative in the T3 subgroup (P = 0.004; Fig 3B) or in clinical stage II (P = 0.0005; Fig 3C), while no significant difference in prognosis was found between Metastasis V-positives and Metastasis V-negatives in the T2, T4 subgroups or in stage III (data not shown). We also evaluated prognostic factors affecting overall survival. According to a univariate analysis, the size diameter (P = 0.02), Laurén classification (P = 0.01) and Metastasis V (P = 0.002) were significantly correlated with patient survival (S2 Table). In a multivariate analysis, Metastasis V (P = 0.037) was found to be independent prognostic factors (S3 Table).


Detection and Characterization of Metastatic Cancer Cells in the Mesogastrium of Gastric Cancer Patients.

Xie D, Liu L, Osaiweran H, Yu C, Sheng F, Gao C, Hu J, Gong J - PLoS ONE (2015)

The overall survival of patients with or without Metastasis V.(A) The Kaplan–Meier overall survival curves showed the prognosis of Metastasis V-positive patients was significantly (P = 0.006) worse than Metastasis V-negative patients. (B-C) Metastasis V-positive patients had a significantly poorer prognosis than Metastasis V-negative patients in the T3 subgroup (P = 0.004; B) or in clinical stage III (P = 0.0005; C).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4643961&req=5

pone.0142970.g003: The overall survival of patients with or without Metastasis V.(A) The Kaplan–Meier overall survival curves showed the prognosis of Metastasis V-positive patients was significantly (P = 0.006) worse than Metastasis V-negative patients. (B-C) Metastasis V-positive patients had a significantly poorer prognosis than Metastasis V-negative patients in the T3 subgroup (P = 0.004; B) or in clinical stage III (P = 0.0005; C).
Mentions: Based on our follow-up data, the prognosis of all Metastasis V-positive patients was significantly (P = 0.006) worse than Metastasis V-negative patients (Fig 3A). In addition, we analysed the prognostic significance of Metastasis V in the different tumor subgroups (T2, T3 and T4) or clinical stages (II and III). The prognosis of the patients with Metastasis V-positive was significantly poorer than those with Metastasis V-negative in the T3 subgroup (P = 0.004; Fig 3B) or in clinical stage II (P = 0.0005; Fig 3C), while no significant difference in prognosis was found between Metastasis V-positives and Metastasis V-negatives in the T2, T4 subgroups or in stage III (data not shown). We also evaluated prognostic factors affecting overall survival. According to a univariate analysis, the size diameter (P = 0.02), Laurén classification (P = 0.01) and Metastasis V (P = 0.002) were significantly correlated with patient survival (S2 Table). In a multivariate analysis, Metastasis V (P = 0.037) was found to be independent prognostic factors (S3 Table).

Bottom Line: Gastric cancer is the second leading cause of cancer death worldwide.Metastasis V was closely associated with tumor invasion depth, along with a number of positive lymph node metastasis.The prognosis of patients with Metastasis V was significantly (P<0.05) worse than those with tumor cell-free mesogastrium.

View Article: PubMed Central - PubMed

Affiliation: Tongji Cancer Research Institute, Tongji Hospital, Tongji Medical College in Huazhong University of Science and Technology, Wuhan, Hubei, China.

ABSTRACT
Gastric cancer is the second leading cause of cancer death worldwide. Here, we propose a novel type of tumor metastasis designated as Metastasis V in gastric cancer. Metastasis V is defined as the appearance of cancer cells in the mesogastrium with perigastric adipose tissue. To detect its incidence and characterize its clinic pathological features, large cross sectional tissue analysis of mesogastrium from 74 patients were used. Metastasis V was detected in 1 of 40 (2.5%) patients with early gastric cancer, 8 of 34 (24%) patients with advanced gastric cancer. The mean distance of Metastasis V from gastric wall was approximately 2.6 cm. Metastasis V was closely associated with tumor invasion depth, along with a number of positive lymph node metastasis. The prognosis of patients with Metastasis V was significantly (P<0.05) worse than those with tumor cell-free mesogastrium. These findings indicate that by using whole-sectional analysis, Metastasis V can be detected in the mesogastrium of gastric cancer patients, and also suggests that it may be a risk factor for patient survival after radical surgery.

Show MeSH
Related in: MedlinePlus