Limits...
Maternal Diabetes and Cognitive Performance in the Offspring: A Systematic Review and Meta-Analysis.

Camprubi Robles M, Campoy C, Garcia Fernandez L, Lopez-Pedrosa JM, Rueda R, Martin MJ - PLoS ONE (2015)

Bottom Line: Infants (1-2 years) of diabetic mothers had significantly lower scores of mental and psychomotor development compared to control infants.The effect size for mental development was -0.41 (95% CI -0.59, -0.24; p<0.0001) and for psychomotor development was -0.31 (95% CI -0.55, -0.07; p = 0.0125) with non-significant heterogeneity.Diabetes during pregnancy could be associated with decreased intelligence quotient scores in school-age children, although studies showed significant heterogeneity.

View Article: PubMed Central - PubMed

Affiliation: Abbott Nutrition, Research and Development-University Science Park, Granada, Spain.

ABSTRACT

Objective: Diabetes during gestation is one of the most common pregnancy complications associated with adverse health effects for the mother and the child. Maternal diabetes has been proposed to negatively affect the cognitive abilities of the child, but experimental research assessing its impact is conflicting. The main aim of our study was to compare the cognitive function in children of diabetic and healthy pregnant women.

Methods: A systematic review and meta-analysis was conducted through a literature search using different electronic databases from the index date to January 31, 2015. We included studies that assessed the cognitive abilities in children (up to 14 years) of diabetic and non-diabetic mothers using standardized and validated neuropsychological tests.

Results: Of 7,698 references reviewed, 12 studies involving 6,140 infants met our inclusion criteria and contributed to meta-analysis. A random effect model was used to compute the standardized mean differences and 95% confidence interval (CI) were calculated. Infants (1-2 years) of diabetic mothers had significantly lower scores of mental and psychomotor development compared to control infants. The effect size for mental development was -0.41 (95% CI -0.59, -0.24; p<0.0001) and for psychomotor development was -0.31 (95% CI -0.55, -0.07; p = 0.0125) with non-significant heterogeneity. Diabetes during pregnancy could be associated with decreased intelligence quotient scores in school-age children, although studies showed significant heterogeneity.

Conclusion: The association between maternal diabetes and deleterious effects on mental/psychomotor development and overall intellectual function in the offspring must be taken with caution. Results are based on observational cohorts and a direct causal influence of intrauterine hyperglycemia remains uncertain. Therefore, more trials that include larger populations are warranted to elucidate whether gestational diabetes mellitus (GDM) has a negative impact on offspring central nervous system (CNS).

Show MeSH

Related in: MedlinePlus

Study flowchart showing the number of studies identified, screened, assessed for eligibility and included in the qualitative and quantitative analysis [17].*Further information regarding the excluded studies can be found in S2 Text.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4643884&req=5

pone.0142583.g001: Study flowchart showing the number of studies identified, screened, assessed for eligibility and included in the qualitative and quantitative analysis [17].*Further information regarding the excluded studies can be found in S2 Text.

Mentions: Fig 1 shows the flowchart of the systematic literature review and meta-analysis. A total number of 7,698 records were identified through database searches. After initial screening, 88 full-text articles were retrieved. Of these, 73 studies were excluded as they did not meet the inclusion criteria (S2 Text).


Maternal Diabetes and Cognitive Performance in the Offspring: A Systematic Review and Meta-Analysis.

Camprubi Robles M, Campoy C, Garcia Fernandez L, Lopez-Pedrosa JM, Rueda R, Martin MJ - PLoS ONE (2015)

Study flowchart showing the number of studies identified, screened, assessed for eligibility and included in the qualitative and quantitative analysis [17].*Further information regarding the excluded studies can be found in S2 Text.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4643884&req=5

pone.0142583.g001: Study flowchart showing the number of studies identified, screened, assessed for eligibility and included in the qualitative and quantitative analysis [17].*Further information regarding the excluded studies can be found in S2 Text.
Mentions: Fig 1 shows the flowchart of the systematic literature review and meta-analysis. A total number of 7,698 records were identified through database searches. After initial screening, 88 full-text articles were retrieved. Of these, 73 studies were excluded as they did not meet the inclusion criteria (S2 Text).

Bottom Line: Infants (1-2 years) of diabetic mothers had significantly lower scores of mental and psychomotor development compared to control infants.The effect size for mental development was -0.41 (95% CI -0.59, -0.24; p<0.0001) and for psychomotor development was -0.31 (95% CI -0.55, -0.07; p = 0.0125) with non-significant heterogeneity.Diabetes during pregnancy could be associated with decreased intelligence quotient scores in school-age children, although studies showed significant heterogeneity.

View Article: PubMed Central - PubMed

Affiliation: Abbott Nutrition, Research and Development-University Science Park, Granada, Spain.

ABSTRACT

Objective: Diabetes during gestation is one of the most common pregnancy complications associated with adverse health effects for the mother and the child. Maternal diabetes has been proposed to negatively affect the cognitive abilities of the child, but experimental research assessing its impact is conflicting. The main aim of our study was to compare the cognitive function in children of diabetic and healthy pregnant women.

Methods: A systematic review and meta-analysis was conducted through a literature search using different electronic databases from the index date to January 31, 2015. We included studies that assessed the cognitive abilities in children (up to 14 years) of diabetic and non-diabetic mothers using standardized and validated neuropsychological tests.

Results: Of 7,698 references reviewed, 12 studies involving 6,140 infants met our inclusion criteria and contributed to meta-analysis. A random effect model was used to compute the standardized mean differences and 95% confidence interval (CI) were calculated. Infants (1-2 years) of diabetic mothers had significantly lower scores of mental and psychomotor development compared to control infants. The effect size for mental development was -0.41 (95% CI -0.59, -0.24; p<0.0001) and for psychomotor development was -0.31 (95% CI -0.55, -0.07; p = 0.0125) with non-significant heterogeneity. Diabetes during pregnancy could be associated with decreased intelligence quotient scores in school-age children, although studies showed significant heterogeneity.

Conclusion: The association between maternal diabetes and deleterious effects on mental/psychomotor development and overall intellectual function in the offspring must be taken with caution. Results are based on observational cohorts and a direct causal influence of intrauterine hyperglycemia remains uncertain. Therefore, more trials that include larger populations are warranted to elucidate whether gestational diabetes mellitus (GDM) has a negative impact on offspring central nervous system (CNS).

Show MeSH
Related in: MedlinePlus