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Experimental investigation of the effect of polymer matrices on polymer fibre optic oxygen sensors and their time response characteristics using a vacuum testing chamber and a liquid flow apparatus.

Chen R, Formenti F, McPeak H, Obeid AN, Hahn C, Farmery A - Sens Actuators B Chem (2016)

Bottom Line: Previous attempts to design fast intravascular electrochemical oxygen sensors for use in physiology and medicine have failed to meet the criteria that are now required in modern investigations.In this article, we present an inexpensive polymer type fibre-optic, oxygen sensor that is two orders of magnitude faster than conventional electrochemical oxygen sensors.It is constructed with biologically inert polymer materials and is both sufficiently small and robust for direct insertion in to a human artery.

View Article: PubMed Central - PubMed

Affiliation: Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

ABSTRACT

Very fast sensors that are able to track rapid changes in oxygen partial pressure (PO2) in the gas and liquid phases are increasingly required in scientific research - particularly in the life sciences. Recent interest in monitoring very fast changes in the PO2 of arterial blood in some respiratory failure conditions is one such example. Previous attempts to design fast intravascular electrochemical oxygen sensors for use in physiology and medicine have failed to meet the criteria that are now required in modern investigations. However, miniature photonic devices are capable of meeting this need. In this article, we present an inexpensive polymer type fibre-optic, oxygen sensor that is two orders of magnitude faster than conventional electrochemical oxygen sensors. It is constructed with biologically inert polymer materials and is both sufficiently small and robust for direct insertion in to a human artery. The sensors were tested and evaluated in both a gas testing chamber and in a flowing liquid test system. The results showed a very fast T 90 response time, typically circa 20 ms when tested in the gas phase, and circa 100 ms in flowing liquid.

No MeSH data available.


Related in: MedlinePlus

PPMA sensor response to PO2 step changes 5 kPa to 30 kPa, and 30 kPa to 5 kPa, in the liquid test circuit. The sensor was 37 days post manufacture. Results are for water at room temperature. Sampling points are 100 ms. A 3 sample median filter has been applied.
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fig0030: PPMA sensor response to PO2 step changes 5 kPa to 30 kPa, and 30 kPa to 5 kPa, in the liquid test circuit. The sensor was 37 days post manufacture. Results are for water at room temperature. Sampling points are 100 ms. A 3 sample median filter has been applied.

Mentions: Fig. 6 shows the PPMA sensor response to PO2 step changes from 5 kPa to 30 kPa, and 30 kPa to 5 kPa, in the liquid test circuit on day 37 post manufacture. It is clear that the step-change has reached its full value within c. 100 ms. Since we have previously shown that the time of switch-over of the two flowing liquids is about 50 ms [25], we can expect the PO2 time response of the sensor to be better than 100 ms in liquid.


Experimental investigation of the effect of polymer matrices on polymer fibre optic oxygen sensors and their time response characteristics using a vacuum testing chamber and a liquid flow apparatus.

Chen R, Formenti F, McPeak H, Obeid AN, Hahn C, Farmery A - Sens Actuators B Chem (2016)

PPMA sensor response to PO2 step changes 5 kPa to 30 kPa, and 30 kPa to 5 kPa, in the liquid test circuit. The sensor was 37 days post manufacture. Results are for water at room temperature. Sampling points are 100 ms. A 3 sample median filter has been applied.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4643756&req=5

fig0030: PPMA sensor response to PO2 step changes 5 kPa to 30 kPa, and 30 kPa to 5 kPa, in the liquid test circuit. The sensor was 37 days post manufacture. Results are for water at room temperature. Sampling points are 100 ms. A 3 sample median filter has been applied.
Mentions: Fig. 6 shows the PPMA sensor response to PO2 step changes from 5 kPa to 30 kPa, and 30 kPa to 5 kPa, in the liquid test circuit on day 37 post manufacture. It is clear that the step-change has reached its full value within c. 100 ms. Since we have previously shown that the time of switch-over of the two flowing liquids is about 50 ms [25], we can expect the PO2 time response of the sensor to be better than 100 ms in liquid.

Bottom Line: Previous attempts to design fast intravascular electrochemical oxygen sensors for use in physiology and medicine have failed to meet the criteria that are now required in modern investigations.In this article, we present an inexpensive polymer type fibre-optic, oxygen sensor that is two orders of magnitude faster than conventional electrochemical oxygen sensors.It is constructed with biologically inert polymer materials and is both sufficiently small and robust for direct insertion in to a human artery.

View Article: PubMed Central - PubMed

Affiliation: Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

ABSTRACT

Very fast sensors that are able to track rapid changes in oxygen partial pressure (PO2) in the gas and liquid phases are increasingly required in scientific research - particularly in the life sciences. Recent interest in monitoring very fast changes in the PO2 of arterial blood in some respiratory failure conditions is one such example. Previous attempts to design fast intravascular electrochemical oxygen sensors for use in physiology and medicine have failed to meet the criteria that are now required in modern investigations. However, miniature photonic devices are capable of meeting this need. In this article, we present an inexpensive polymer type fibre-optic, oxygen sensor that is two orders of magnitude faster than conventional electrochemical oxygen sensors. It is constructed with biologically inert polymer materials and is both sufficiently small and robust for direct insertion in to a human artery. The sensors were tested and evaluated in both a gas testing chamber and in a flowing liquid test system. The results showed a very fast T 90 response time, typically circa 20 ms when tested in the gas phase, and circa 100 ms in flowing liquid.

No MeSH data available.


Related in: MedlinePlus