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Interstitial brachytherapy technique for chest wall refractory recurrence of breast cancer.

Wu N, Chen Q, Zhao Z, Zhao H, Cheng G - J Contemp Brachytherapy (2015)

Bottom Line: This 44-year-old female presented with chest wall recurrence seven years after modified radical mastectomy for stage II breast cancer.Despite external beam radiation and chemotherapy, the lesion expanded as 5.3 × 5.1 × 3.0 cm(3), and 8.0 × 5.1 × 4.0 cm(3).Removal of the recurrent tumor was securely achieved by interstitial brachytherapy guided with ultrasound scanning.

View Article: PubMed Central - PubMed

Affiliation: These two authors contributed equally to this work.

ABSTRACT

Purpose: To report the treatment effect of interstitial brachytherapy for chest wall locoregional recurrence of breast cancer.

Material and methods: This 44-year-old female presented with chest wall recurrence seven years after modified radical mastectomy for stage II breast cancer. Despite external beam radiation and chemotherapy, the lesion expanded as 5.3 × 5.1 × 3.0 cm(3), and 8.0 × 5.1 × 4.0 cm(3). The locoregional recurrent tumor was treated with interstitial brachytherapy under ultrasound guidance. The brachytherapy dose was 30 Gy in 6 fractions of 5 Gy each.

Results: Removal of the recurrent tumor was securely achieved by interstitial brachytherapy guided with ultrasound scanning. The refractory tumor in patient healed uneventfully after interstitial brachytherapy without recurrence during the 7 months of follow-up.

Conclusions: The ultrasound-guided interstitial brachytherapy may be effective for refractory recurrence of breast cancer.

No MeSH data available.


Related in: MedlinePlus

The position of applicator needles in CT images
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Figure 0003: The position of applicator needles in CT images

Mentions: Before processing each treatment, informed consent was obtained from the patient. Treatments were performed with standard institutional approval. HDR-interstitial brachytherapy followed by external radiotherapy in total dose of 30 Gy in 6 fractions during 3 days (5 Gy each fraction, twice a day with 6 hours interval, 3 days) was applied treatment and was accomplished with OncoSmart ProGuide catheters (Nucletron, an Elekta company, Elekta AB, Stockholm, Sweden). Treatment was performed under anesthesia during the procedure. Eleven applicator catheters (1.1 mm in external diameter and 20 cm in length) were inserted to the target under ultrasound guidance, with interval of 1.5 cm to make sure the adequate dose distribution and target volume coverage (see Figure 2). OncoSmart ProGuide CT-Markers were put inside the catheters in order to facilitate their reconstruction. After implanting the applicators, fine-pitch (2 mm) X-ray CT images were then acquired and transferred to the treatment planning computer (see Figure 3). The CT-imaging data before interstitial brachytherapy was used to contour GTV and CTV. The CTV was expanded from GTV by 2.0 cm and restricted by the volume of critical organs (especially right lung). A CT-based treatment plan was created using a graphic optimization tool (Treatment Planning System Oncentra V4.3; Nucletron, Veenendaal, The Netherlands). The normalization and optimization to the target volume was performed.


Interstitial brachytherapy technique for chest wall refractory recurrence of breast cancer.

Wu N, Chen Q, Zhao Z, Zhao H, Cheng G - J Contemp Brachytherapy (2015)

The position of applicator needles in CT images
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4643729&req=5

Figure 0003: The position of applicator needles in CT images
Mentions: Before processing each treatment, informed consent was obtained from the patient. Treatments were performed with standard institutional approval. HDR-interstitial brachytherapy followed by external radiotherapy in total dose of 30 Gy in 6 fractions during 3 days (5 Gy each fraction, twice a day with 6 hours interval, 3 days) was applied treatment and was accomplished with OncoSmart ProGuide catheters (Nucletron, an Elekta company, Elekta AB, Stockholm, Sweden). Treatment was performed under anesthesia during the procedure. Eleven applicator catheters (1.1 mm in external diameter and 20 cm in length) were inserted to the target under ultrasound guidance, with interval of 1.5 cm to make sure the adequate dose distribution and target volume coverage (see Figure 2). OncoSmart ProGuide CT-Markers were put inside the catheters in order to facilitate their reconstruction. After implanting the applicators, fine-pitch (2 mm) X-ray CT images were then acquired and transferred to the treatment planning computer (see Figure 3). The CT-imaging data before interstitial brachytherapy was used to contour GTV and CTV. The CTV was expanded from GTV by 2.0 cm and restricted by the volume of critical organs (especially right lung). A CT-based treatment plan was created using a graphic optimization tool (Treatment Planning System Oncentra V4.3; Nucletron, Veenendaal, The Netherlands). The normalization and optimization to the target volume was performed.

Bottom Line: This 44-year-old female presented with chest wall recurrence seven years after modified radical mastectomy for stage II breast cancer.Despite external beam radiation and chemotherapy, the lesion expanded as 5.3 × 5.1 × 3.0 cm(3), and 8.0 × 5.1 × 4.0 cm(3).Removal of the recurrent tumor was securely achieved by interstitial brachytherapy guided with ultrasound scanning.

View Article: PubMed Central - PubMed

Affiliation: These two authors contributed equally to this work.

ABSTRACT

Purpose: To report the treatment effect of interstitial brachytherapy for chest wall locoregional recurrence of breast cancer.

Material and methods: This 44-year-old female presented with chest wall recurrence seven years after modified radical mastectomy for stage II breast cancer. Despite external beam radiation and chemotherapy, the lesion expanded as 5.3 × 5.1 × 3.0 cm(3), and 8.0 × 5.1 × 4.0 cm(3). The locoregional recurrent tumor was treated with interstitial brachytherapy under ultrasound guidance. The brachytherapy dose was 30 Gy in 6 fractions of 5 Gy each.

Results: Removal of the recurrent tumor was securely achieved by interstitial brachytherapy guided with ultrasound scanning. The refractory tumor in patient healed uneventfully after interstitial brachytherapy without recurrence during the 7 months of follow-up.

Conclusions: The ultrasound-guided interstitial brachytherapy may be effective for refractory recurrence of breast cancer.

No MeSH data available.


Related in: MedlinePlus