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Fosfomycin tromethamine. Antibiotic of choice in the female patient: A multicenter study.

Khawaja AR, Khan FB, Dar TI, Bhat AH, Wani MS, Wazir BS - Cent European J Urol (2015)

Bottom Line: Fosfomycin Trometamol is a bactericidal antibiotic with a broad spectrum activity against Gram-positive also Gram-negative bacteriae.It has an advantage of oral single /multiple doses, higher eradication rate of bacteria after 48 hours, excellent tolerability and safety in pregnancy and other female age groups.We recommend Fosfomycin Trometamol as the drug of choice particularly in patients with poor drug compliance and for minor day care endourological procedures.

View Article: PubMed Central - PubMed

Affiliation: Sheri Kashmir Institute of Medical Sciences Soura Srinagar; Government Medical College Srinagar Jammu and Kashmir, India.

ABSTRACT

Introduction: The aim of this study was to evaluate oral single/multiple doses of Fosfomycin Trometamol with clinical and microbiological efficacy in:Asymptomatic bacteriuria in pregnancy.Endourological procedures.Lower urinary tract infections.

Material and methods: This prospective, uncontrolled, open label study was conducted in two tertiary hospitals over a period of three years. A total of 400 patients were included in the study. Group A (200 patients) with asymptomatic bacteriuria in pregnancy and Group B (200 Patients) with symptomatic lower urinary tract infections and with any day care endourological procedures were enrolled in our study. Efficacy end points like post- antibiotic urinalysis, microbiological efficacy and clinical improvement with adverse effects of the drug were evaluated.

Results: Of the 400 patients studied, 98% returned for follow-up. Out of the 304 urinary isolates in Table 2 (ASB and symptomatic LUTS) grown on urinary culture, majority of the isolates were Gram-negative Enterobacteriacae family. After oral single/multiple doses of fosfomycin, bacterial eradication, bacterial persistence, bacterial reinfection were 96.3%, 3.9%, 3.9% respectively (Figure 2). No isolates were grown in 8 cases (Table 2). However, on administration of the drug 23.5% patients noticed diarrhea (loose stools) followed by itching (19.7%) in genital area (Figure 1).

Conclusions: Fosfomycin Trometamol is a bactericidal antibiotic with a broad spectrum activity against Gram-positive also Gram-negative bacteriae. It has an advantage of oral single /multiple doses, higher eradication rate of bacteria after 48 hours, excellent tolerability and safety in pregnancy and other female age groups. We recommend Fosfomycin Trometamol as the drug of choice particularly in patients with poor drug compliance and for minor day care endourological procedures.

No MeSH data available.


Related in: MedlinePlus

Adverse effects of Fosfomycin Tromethamine taken orally (n = 400).
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Figure 0001: Adverse effects of Fosfomycin Tromethamine taken orally (n = 400).

Mentions: In Group A, the majority of the patients were in the average socioeconomic status and were in the age group of 30–40 yrs. While in Group B, the majority of the patients were in the poor socioeconomic status and were in the age group <30 years (Table 1). Most of the urinary isolates grown on the culture were in the Enterobacteriaceae family (Table 2). Total E.Coli in both groups was 178 followed by ESBL (E.Coli) 25 in both groups. Gram-positive cocci were in 17 cases and polymicrobial infections were seen in 9 cases. No isolates were seen in 8 cases. However, adverse effects (Figure 1) were mild in the form of loose stools (diarrhea) (23.5%), itching in the genital area (19.75%), abdominal pain (3.75%) followed by back pain (3.75%). Side effects were transient and self-limited. Out of the 304 urinary isolates, the majority of isolates were sensitive to fosfomycin with bacterial eradication, bacterial persistence and bacterial reinfection being 96.3%, 3.9%, 3.9% respectively (Figure 2). In our study there were 25 isolates of the extended spectrum beta lactamases (ESBL) with bacterial persistence in 4 cases and bacterial reinfection in 1 case (Table 2). Out of the 25 isolates (ESBL), 20 (80%) were sensitive to fosfomycin.


Fosfomycin tromethamine. Antibiotic of choice in the female patient: A multicenter study.

Khawaja AR, Khan FB, Dar TI, Bhat AH, Wani MS, Wazir BS - Cent European J Urol (2015)

Adverse effects of Fosfomycin Tromethamine taken orally (n = 400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4643705&req=5

Figure 0001: Adverse effects of Fosfomycin Tromethamine taken orally (n = 400).
Mentions: In Group A, the majority of the patients were in the average socioeconomic status and were in the age group of 30–40 yrs. While in Group B, the majority of the patients were in the poor socioeconomic status and were in the age group <30 years (Table 1). Most of the urinary isolates grown on the culture were in the Enterobacteriaceae family (Table 2). Total E.Coli in both groups was 178 followed by ESBL (E.Coli) 25 in both groups. Gram-positive cocci were in 17 cases and polymicrobial infections were seen in 9 cases. No isolates were seen in 8 cases. However, adverse effects (Figure 1) were mild in the form of loose stools (diarrhea) (23.5%), itching in the genital area (19.75%), abdominal pain (3.75%) followed by back pain (3.75%). Side effects were transient and self-limited. Out of the 304 urinary isolates, the majority of isolates were sensitive to fosfomycin with bacterial eradication, bacterial persistence and bacterial reinfection being 96.3%, 3.9%, 3.9% respectively (Figure 2). In our study there were 25 isolates of the extended spectrum beta lactamases (ESBL) with bacterial persistence in 4 cases and bacterial reinfection in 1 case (Table 2). Out of the 25 isolates (ESBL), 20 (80%) were sensitive to fosfomycin.

Bottom Line: Fosfomycin Trometamol is a bactericidal antibiotic with a broad spectrum activity against Gram-positive also Gram-negative bacteriae.It has an advantage of oral single /multiple doses, higher eradication rate of bacteria after 48 hours, excellent tolerability and safety in pregnancy and other female age groups.We recommend Fosfomycin Trometamol as the drug of choice particularly in patients with poor drug compliance and for minor day care endourological procedures.

View Article: PubMed Central - PubMed

Affiliation: Sheri Kashmir Institute of Medical Sciences Soura Srinagar; Government Medical College Srinagar Jammu and Kashmir, India.

ABSTRACT

Introduction: The aim of this study was to evaluate oral single/multiple doses of Fosfomycin Trometamol with clinical and microbiological efficacy in:Asymptomatic bacteriuria in pregnancy.Endourological procedures.Lower urinary tract infections.

Material and methods: This prospective, uncontrolled, open label study was conducted in two tertiary hospitals over a period of three years. A total of 400 patients were included in the study. Group A (200 patients) with asymptomatic bacteriuria in pregnancy and Group B (200 Patients) with symptomatic lower urinary tract infections and with any day care endourological procedures were enrolled in our study. Efficacy end points like post- antibiotic urinalysis, microbiological efficacy and clinical improvement with adverse effects of the drug were evaluated.

Results: Of the 400 patients studied, 98% returned for follow-up. Out of the 304 urinary isolates in Table 2 (ASB and symptomatic LUTS) grown on urinary culture, majority of the isolates were Gram-negative Enterobacteriacae family. After oral single/multiple doses of fosfomycin, bacterial eradication, bacterial persistence, bacterial reinfection were 96.3%, 3.9%, 3.9% respectively (Figure 2). No isolates were grown in 8 cases (Table 2). However, on administration of the drug 23.5% patients noticed diarrhea (loose stools) followed by itching (19.7%) in genital area (Figure 1).

Conclusions: Fosfomycin Trometamol is a bactericidal antibiotic with a broad spectrum activity against Gram-positive also Gram-negative bacteriae. It has an advantage of oral single /multiple doses, higher eradication rate of bacteria after 48 hours, excellent tolerability and safety in pregnancy and other female age groups. We recommend Fosfomycin Trometamol as the drug of choice particularly in patients with poor drug compliance and for minor day care endourological procedures.

No MeSH data available.


Related in: MedlinePlus