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CyberKnife-based prostate cancer patient radioablation - early results of irradiation in 200 patients.

Miszczyk L, Napieralska A, Namysł-Kaletka A, Głowacki G, Grabińska K, Woźniak G, Stąpór-Fudzińska M - Cent European J Urol (2015)

Bottom Line: The maximum percentage of acute G3 adverse effects was 0.6% for GI, 1% for GU and G2 - 2.1% for GI and 8.5% for GU.Median PSA decreased from 7.7 to 0.1 ng/ml during FU.We conclude that CK-based radioablation in low and intermediate risk PC patients is an effective treatment modality enabling OTT reduction and presents a very low percentage of adverse effects.

View Article: PubMed Central - PubMed

Affiliation: M. Skłodowska-Curie Cancer Center and Institute of Oncology, Gliwice Branch, Poland.

ABSTRACT

Introduction: Prostrate cancer (PC) is one of the most common malignancies and is frequently treated with an 8-week course of radiotherapy. CyberKnife (CK) based radioablation enables completion of therapy within 5-9 days. The aim of this study is an evaluation of the effectiveness and tolerance of CyberKnife-based radioablation in prostate cancer patients.

Material and methods: 200 PC patients (94 low risk [LR], 106 intermediate risk [IR]) underwent CK irradiation every other day (fraction dose [fd] 7.25 Gy, total dose [TD] 36.25 Gy, time 9 days). PSA varied from 1.1 to 19.5 (median 7.7) and T stage from T1c to T2c. The percentage of patients with Androgen Deprivation Therapy (ADT), GI (gastrointestinal) and GU (genitourinary) toxicity (EORTC/RTOG scale), and PSA were checked at 1, 4 and 8 months, and thereafter every 6 months - up to a total of 26 months - post-treatment.

Results: The percentage of patients without ADT increased from 47.5% to 94.1% after 26 months. The maximum percentage of acute G3 adverse effects was 0.6% for GI, 1% for GU and G2 - 2.1% for GI and 8.5% for GU. No late G3 toxicity was observed. The maximum percentage of late G2 toxicity was 0.7% for GI and 3.4% for GU. Median PSA decreased from 7.7 to 0.1 ng/ml during FU. One patient relapsed and was treated with salvage brachytherapy.

Conclusions: We conclude that CK-based radioablation in low and intermediate risk PC patients is an effective treatment modality enabling OTT reduction and presents a very low percentage of adverse effects.

No MeSH data available.


Related in: MedlinePlus

Beams’ configuration and the dose distribution.
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Figure 0004: Beams’ configuration and the dose distribution.

Mentions: Radiotherapy planning (inverse) was performed on the basis of the CT and MRI fusion using the Multiplan system. Planning, as well as irradiation, was non-isocentric. Typically, between 180 to 250 beams were used (Figure 4).


CyberKnife-based prostate cancer patient radioablation - early results of irradiation in 200 patients.

Miszczyk L, Napieralska A, Namysł-Kaletka A, Głowacki G, Grabińska K, Woźniak G, Stąpór-Fudzińska M - Cent European J Urol (2015)

Beams’ configuration and the dose distribution.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4643703&req=5

Figure 0004: Beams’ configuration and the dose distribution.
Mentions: Radiotherapy planning (inverse) was performed on the basis of the CT and MRI fusion using the Multiplan system. Planning, as well as irradiation, was non-isocentric. Typically, between 180 to 250 beams were used (Figure 4).

Bottom Line: The maximum percentage of acute G3 adverse effects was 0.6% for GI, 1% for GU and G2 - 2.1% for GI and 8.5% for GU.Median PSA decreased from 7.7 to 0.1 ng/ml during FU.We conclude that CK-based radioablation in low and intermediate risk PC patients is an effective treatment modality enabling OTT reduction and presents a very low percentage of adverse effects.

View Article: PubMed Central - PubMed

Affiliation: M. Skłodowska-Curie Cancer Center and Institute of Oncology, Gliwice Branch, Poland.

ABSTRACT

Introduction: Prostrate cancer (PC) is one of the most common malignancies and is frequently treated with an 8-week course of radiotherapy. CyberKnife (CK) based radioablation enables completion of therapy within 5-9 days. The aim of this study is an evaluation of the effectiveness and tolerance of CyberKnife-based radioablation in prostate cancer patients.

Material and methods: 200 PC patients (94 low risk [LR], 106 intermediate risk [IR]) underwent CK irradiation every other day (fraction dose [fd] 7.25 Gy, total dose [TD] 36.25 Gy, time 9 days). PSA varied from 1.1 to 19.5 (median 7.7) and T stage from T1c to T2c. The percentage of patients with Androgen Deprivation Therapy (ADT), GI (gastrointestinal) and GU (genitourinary) toxicity (EORTC/RTOG scale), and PSA were checked at 1, 4 and 8 months, and thereafter every 6 months - up to a total of 26 months - post-treatment.

Results: The percentage of patients without ADT increased from 47.5% to 94.1% after 26 months. The maximum percentage of acute G3 adverse effects was 0.6% for GI, 1% for GU and G2 - 2.1% for GI and 8.5% for GU. No late G3 toxicity was observed. The maximum percentage of late G2 toxicity was 0.7% for GI and 3.4% for GU. Median PSA decreased from 7.7 to 0.1 ng/ml during FU. One patient relapsed and was treated with salvage brachytherapy.

Conclusions: We conclude that CK-based radioablation in low and intermediate risk PC patients is an effective treatment modality enabling OTT reduction and presents a very low percentage of adverse effects.

No MeSH data available.


Related in: MedlinePlus