Asymmetrical white matter networks for attending to global versus local features.
Bottom Line: We found (i) that reproduction of local features in figure copying was supported by a neural network confined to the left hemisphere, consisting of cortical loci within parietal, occipital and insular lobes and interconnected by the inferior-fronto-occipital fasciculus (IFOF), and (ii) that global feature processing was associated with a right hemisphere network interconnected by the third branch of the superior longitudinal fasciculus and the long segment of the perisylvian network.The data support the argument that asymmetrical white matter disconnections within long-range association pathways predict poor complex figure drawing resulting from deficits in hierarchical representation.We conclude that hemispheric asymmetries in attending to local versus global features exist on the level of both cortical loci and the supporting white matter pathways.
Affiliation: Department of Experimental Psychology, University of Oxford, Oxford, UK. Electronic address: email@example.com.Show MeSH
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Mentions: We adopted here a hodological approach to understanding the contribution of white matter disconnections to cognitive symptoms (Catani and Mesulam, 2008a, Catani and Mesulam, 2008b, Rudrauf et al., 2008, Thiebaut de Schotten et al., 2008) based on linear regression performed to identify specific white matter pathways, which when damaged predict deficits in local versus global processing in complex figure copying. The linear regression analysis indicated that lateralized damage within the left and right hemispheres contributes specifically to local versus global processing deficits respectively. Damage within the left IFOF was a predictor of local processing deficits in the complex figure copy test (β = .210; p = .001; Fig. 3A), while damage within the right SLFIII (β = .213; p = .001; Fig. 3B) and the long segment of perisylvian network (long segment of arcuate fasciculus; β = .189; p = .003; Fig. 3B) were predictors of global processing deficits.
Affiliation: Department of Experimental Psychology, University of Oxford, Oxford, UK. Electronic address: firstname.lastname@example.org.