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Asymmetrical white matter networks for attending to global versus local features.

Chechlacz M, Mantini D, Gillebert CR, Humphreys GW - Cortex (2015)

Bottom Line: We found (i) that reproduction of local features in figure copying was supported by a neural network confined to the left hemisphere, consisting of cortical loci within parietal, occipital and insular lobes and interconnected by the inferior-fronto-occipital fasciculus (IFOF), and (ii) that global feature processing was associated with a right hemisphere network interconnected by the third branch of the superior longitudinal fasciculus and the long segment of the perisylvian network.The data support the argument that asymmetrical white matter disconnections within long-range association pathways predict poor complex figure drawing resulting from deficits in hierarchical representation.We conclude that hemispheric asymmetries in attending to local versus global features exist on the level of both cortical loci and the supporting white matter pathways.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Psychology, University of Oxford, Oxford, UK. Electronic address: magdalena.chechlacz@psy.ox.ac.uk.

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Distribution of (A) global and (B) local processing scores in the performance on the BCoS Complex Figure Copy Test in the studied group of patients (n = 248). Examples of patients' performance on BCoS Complex Figure Copy consistent with diagnosis of (C) global and (D) local processing deficits.
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fig2: Distribution of (A) global and (B) local processing scores in the performance on the BCoS Complex Figure Copy Test in the studied group of patients (n = 248). Examples of patients' performance on BCoS Complex Figure Copy consistent with diagnosis of (C) global and (D) local processing deficits.

Mentions: The overall lesion distribution within both hemispheres is illustrated in Fig. 1B and the percentages of patients with disconnections in (i) association, (ii) commissural and (iii) projection white matter pathways within the left and right hemispheres are shown in Fig. 1C. We subsequently examined the neural correlates of deficits in global versus local processing as assessed by performance on the BCoS complex figure copying test. Fig. 2 shows the distribution of global and local scores in the studied group of patients as well as examples of the BCoS complex figure test performance illustrating global and local processing impairments. We found no difference in performances between male and female patients [global processing, t(246) = 1.14, p = .25; local processing, t(246) = .26, p = .80].


Asymmetrical white matter networks for attending to global versus local features.

Chechlacz M, Mantini D, Gillebert CR, Humphreys GW - Cortex (2015)

Distribution of (A) global and (B) local processing scores in the performance on the BCoS Complex Figure Copy Test in the studied group of patients (n = 248). Examples of patients' performance on BCoS Complex Figure Copy consistent with diagnosis of (C) global and (D) local processing deficits.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4643681&req=5

fig2: Distribution of (A) global and (B) local processing scores in the performance on the BCoS Complex Figure Copy Test in the studied group of patients (n = 248). Examples of patients' performance on BCoS Complex Figure Copy consistent with diagnosis of (C) global and (D) local processing deficits.
Mentions: The overall lesion distribution within both hemispheres is illustrated in Fig. 1B and the percentages of patients with disconnections in (i) association, (ii) commissural and (iii) projection white matter pathways within the left and right hemispheres are shown in Fig. 1C. We subsequently examined the neural correlates of deficits in global versus local processing as assessed by performance on the BCoS complex figure copying test. Fig. 2 shows the distribution of global and local scores in the studied group of patients as well as examples of the BCoS complex figure test performance illustrating global and local processing impairments. We found no difference in performances between male and female patients [global processing, t(246) = 1.14, p = .25; local processing, t(246) = .26, p = .80].

Bottom Line: We found (i) that reproduction of local features in figure copying was supported by a neural network confined to the left hemisphere, consisting of cortical loci within parietal, occipital and insular lobes and interconnected by the inferior-fronto-occipital fasciculus (IFOF), and (ii) that global feature processing was associated with a right hemisphere network interconnected by the third branch of the superior longitudinal fasciculus and the long segment of the perisylvian network.The data support the argument that asymmetrical white matter disconnections within long-range association pathways predict poor complex figure drawing resulting from deficits in hierarchical representation.We conclude that hemispheric asymmetries in attending to local versus global features exist on the level of both cortical loci and the supporting white matter pathways.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Psychology, University of Oxford, Oxford, UK. Electronic address: magdalena.chechlacz@psy.ox.ac.uk.

Show MeSH
Related in: MedlinePlus