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Imaging characteristics of disseminated Geosmithia argillacea causing severe diskospondylitis and meningoencephalomyelitis in a dog.

Kawalilak LT, Chen AV, Roberts GR - Clin Case Rep (2015)

Bottom Line: A 4-year-old male castrated Labrador Retriever presented for severe spinal pain.Blood culture revealed a Geosmithia argillacea fungal infection after DNA sequencing, initially misdiagnosed as Penicillium species.Geosmithia argillacea should be considered as a differential for disseminated fungal diskospondylitis.

View Article: PubMed Central - PubMed

Affiliation: Veterinary Clinical Sciences, Washington State University 99164-7010, Pullman, Washington.

ABSTRACT
A 4-year-old male castrated Labrador Retriever presented for severe spinal pain. Radiographs and magnetic resonance imaging showed evidence of diskospondylitis and meningoencephalomyelitis. Blood culture revealed a Geosmithia argillacea fungal infection after DNA sequencing, initially misdiagnosed as Penicillium species. Geosmithia argillacea should be considered as a differential for disseminated fungal diskospondylitis.

No MeSH data available.


Related in: MedlinePlus

Fluid attenuated inversion recovery (A), T2-weighted (B) axial images and postmortem section (C) of the brain at the level of thalamus. The left lateral ventricle is enlarged (*), containing T2 hyperintense and FLAIR hypointense fluid, consistent with cerebrospinal fluid. This is causing compression on the thalamus and midline deviation of the falx to the right. The FLAIR image also shows a small rim of periventricular hyperintensity surrounding the left lateral ventricle (white arrow).
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fig02: Fluid attenuated inversion recovery (A), T2-weighted (B) axial images and postmortem section (C) of the brain at the level of thalamus. The left lateral ventricle is enlarged (*), containing T2 hyperintense and FLAIR hypointense fluid, consistent with cerebrospinal fluid. This is causing compression on the thalamus and midline deviation of the falx to the right. The FLAIR image also shows a small rim of periventricular hyperintensity surrounding the left lateral ventricle (white arrow).

Mentions: Approximately 10 months following the previous discharge (11 months from initial presentation) the dog presented with severe acute neurologic signs including circling to the left, right hemiparesis, and neck pain. A left supratentorial lesion was suspected. The dog was euthanized at the owner's request and additional imaging of the cadaver was performed. Magnetic resonance (MR) imaging of the brain and cervical spinal column was performed immediately following euthanasia using a 1.0T MR imaging system (Philips NT10 Gyroscan Intera; Philips Medical Systems, Andover, MA). T1-weighted (T1-W), T2-weighted (T2-W), and fluid attenuated inversion recovery (FLAIR) images (4 mm slices) in sagittal, coronal, and axial planes were reviewed. A marked dilation of the left lateral ventricle causing compression of the left thalamus and a midline shift of the falx to the right was noted. The fluid within the lateral ventricle was hyperintense on T2-W images and hypointense on the T1-W and FLAIR images, consistent with cerebrospinal fluid (CSF) (Fig.2A and B). The dilated ventricle also extended caudally causing compression of the midbrain and cerebellum. A hyperintense rim surrounded the left lateral ventricle on the FLAIR images. A single 0.3 cm × 0.7 cm ill-defined, curvilinear, T2-W, and FLAIR hyperintensity was present in the left dorsorostral cerebrum, although this could not be differentiated from the edema related to the enlarged left lateral ventricle due to the lack of a contrast study. The intervertebral disk spaces of C2–C5 were narrowed with irregular contours and T2-W hyperintense end plates suggestive of diskospondyitis.


Imaging characteristics of disseminated Geosmithia argillacea causing severe diskospondylitis and meningoencephalomyelitis in a dog.

Kawalilak LT, Chen AV, Roberts GR - Clin Case Rep (2015)

Fluid attenuated inversion recovery (A), T2-weighted (B) axial images and postmortem section (C) of the brain at the level of thalamus. The left lateral ventricle is enlarged (*), containing T2 hyperintense and FLAIR hypointense fluid, consistent with cerebrospinal fluid. This is causing compression on the thalamus and midline deviation of the falx to the right. The FLAIR image also shows a small rim of periventricular hyperintensity surrounding the left lateral ventricle (white arrow).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4641471&req=5

fig02: Fluid attenuated inversion recovery (A), T2-weighted (B) axial images and postmortem section (C) of the brain at the level of thalamus. The left lateral ventricle is enlarged (*), containing T2 hyperintense and FLAIR hypointense fluid, consistent with cerebrospinal fluid. This is causing compression on the thalamus and midline deviation of the falx to the right. The FLAIR image also shows a small rim of periventricular hyperintensity surrounding the left lateral ventricle (white arrow).
Mentions: Approximately 10 months following the previous discharge (11 months from initial presentation) the dog presented with severe acute neurologic signs including circling to the left, right hemiparesis, and neck pain. A left supratentorial lesion was suspected. The dog was euthanized at the owner's request and additional imaging of the cadaver was performed. Magnetic resonance (MR) imaging of the brain and cervical spinal column was performed immediately following euthanasia using a 1.0T MR imaging system (Philips NT10 Gyroscan Intera; Philips Medical Systems, Andover, MA). T1-weighted (T1-W), T2-weighted (T2-W), and fluid attenuated inversion recovery (FLAIR) images (4 mm slices) in sagittal, coronal, and axial planes were reviewed. A marked dilation of the left lateral ventricle causing compression of the left thalamus and a midline shift of the falx to the right was noted. The fluid within the lateral ventricle was hyperintense on T2-W images and hypointense on the T1-W and FLAIR images, consistent with cerebrospinal fluid (CSF) (Fig.2A and B). The dilated ventricle also extended caudally causing compression of the midbrain and cerebellum. A hyperintense rim surrounded the left lateral ventricle on the FLAIR images. A single 0.3 cm × 0.7 cm ill-defined, curvilinear, T2-W, and FLAIR hyperintensity was present in the left dorsorostral cerebrum, although this could not be differentiated from the edema related to the enlarged left lateral ventricle due to the lack of a contrast study. The intervertebral disk spaces of C2–C5 were narrowed with irregular contours and T2-W hyperintense end plates suggestive of diskospondyitis.

Bottom Line: A 4-year-old male castrated Labrador Retriever presented for severe spinal pain.Blood culture revealed a Geosmithia argillacea fungal infection after DNA sequencing, initially misdiagnosed as Penicillium species.Geosmithia argillacea should be considered as a differential for disseminated fungal diskospondylitis.

View Article: PubMed Central - PubMed

Affiliation: Veterinary Clinical Sciences, Washington State University 99164-7010, Pullman, Washington.

ABSTRACT
A 4-year-old male castrated Labrador Retriever presented for severe spinal pain. Radiographs and magnetic resonance imaging showed evidence of diskospondylitis and meningoencephalomyelitis. Blood culture revealed a Geosmithia argillacea fungal infection after DNA sequencing, initially misdiagnosed as Penicillium species. Geosmithia argillacea should be considered as a differential for disseminated fungal diskospondylitis.

No MeSH data available.


Related in: MedlinePlus