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Does type 1 diabetes mellitus affect Achilles tendon response to a 10 km run? A case control study.

Wong AM, Docking SI, Cook JL, Gaida JE - BMC Musculoskelet Disord (2015)

Bottom Line: All regularly ran distances greater than 5 km and VISA-A scores indicated good tendon function (T1DM = 94 ± 11, control = 94 ± 10).Active individuals with T1DM do not have a heightened Achilles tendon response to load, which suggests no increased risk of tendon injury.We cannot extrapolate these findings to sedentary individuals with T1DM.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiotherapy, Monash University, Frankston, 3199, VIC, Australia. andrea.wong90@gmail.com.

ABSTRACT

Background: Achilles tendon structure deteriorates 2-days after maximal loading in elite athletes. The load-response behaviour of tendons may be altered in type 1 diabetes mellitus (T1DM) as hyperglycaemia accelerates collagen cross-linking. This study compared Achilles tendon load-response in participants with T1DM and controls.

Methods: Achilles tendon structure was quantified at day-0, day-2 and day-4 after a 10 km run. Ultrasound tissue characterisation (UTC) measures tendon structural integrity by classifying pixels as echo-type I, II, III or IV. Echo-type I has the most aligned collagen fibrils and IV has the least.

Results: Participants were 7 individuals with T1DM and 10 controls. All regularly ran distances greater than 5 km and VISA-A scores indicated good tendon function (T1DM = 94 ± 11, control = 94 ± 10). There were no diabetic complications and HbA1c was 8.7 ± 2.6 mmol/mol for T1DM and 5.3 ± 0.4 mmol/mol for control groups. Baseline tendon structure was similar in T1DM and control groups - UTC echo-types (I-IV) and anterior-posterior thickness were all p > 0.05. No response to load was seen in either T1DM or control group over the 4-days post exercise.

Conclusion: Active individuals with T1DM do not have a heightened Achilles tendon response to load, which suggests no increased risk of tendon injury. We cannot extrapolate these findings to sedentary individuals with T1DM.

No MeSH data available.


Related in: MedlinePlus

UTC image of a control Achilles tendon in transverse view at baseline (Day 0). The border of the Achilles tendon is demarcated by the white line, with the surrounding pixels greyed out. Echo-types I, II, III and IV are represented as green, blue, red and black respectively
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Fig3: UTC image of a control Achilles tendon in transverse view at baseline (Day 0). The border of the Achilles tendon is demarcated by the white line, with the surrounding pixels greyed out. Echo-types I, II, III and IV are represented as green, blue, red and black respectively

Mentions: No significant differences were observed between the groups on day 0 for echo-types I, II, III or IV (p = 0.313, 0.562, 0.492, 0.368 respectively, Fig. 1). Similarly, no significant difference was observed in day 0 AP tendon thickness between the T1DM and control groups (0.51 ± 0.10 cm, 0.49 ± 0.05 cm respectively, p = 0.368, Figs. 2 and 3 respectively).Fig. 1


Does type 1 diabetes mellitus affect Achilles tendon response to a 10 km run? A case control study.

Wong AM, Docking SI, Cook JL, Gaida JE - BMC Musculoskelet Disord (2015)

UTC image of a control Achilles tendon in transverse view at baseline (Day 0). The border of the Achilles tendon is demarcated by the white line, with the surrounding pixels greyed out. Echo-types I, II, III and IV are represented as green, blue, red and black respectively
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4641391&req=5

Fig3: UTC image of a control Achilles tendon in transverse view at baseline (Day 0). The border of the Achilles tendon is demarcated by the white line, with the surrounding pixels greyed out. Echo-types I, II, III and IV are represented as green, blue, red and black respectively
Mentions: No significant differences were observed between the groups on day 0 for echo-types I, II, III or IV (p = 0.313, 0.562, 0.492, 0.368 respectively, Fig. 1). Similarly, no significant difference was observed in day 0 AP tendon thickness between the T1DM and control groups (0.51 ± 0.10 cm, 0.49 ± 0.05 cm respectively, p = 0.368, Figs. 2 and 3 respectively).Fig. 1

Bottom Line: All regularly ran distances greater than 5 km and VISA-A scores indicated good tendon function (T1DM = 94 ± 11, control = 94 ± 10).Active individuals with T1DM do not have a heightened Achilles tendon response to load, which suggests no increased risk of tendon injury.We cannot extrapolate these findings to sedentary individuals with T1DM.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiotherapy, Monash University, Frankston, 3199, VIC, Australia. andrea.wong90@gmail.com.

ABSTRACT

Background: Achilles tendon structure deteriorates 2-days after maximal loading in elite athletes. The load-response behaviour of tendons may be altered in type 1 diabetes mellitus (T1DM) as hyperglycaemia accelerates collagen cross-linking. This study compared Achilles tendon load-response in participants with T1DM and controls.

Methods: Achilles tendon structure was quantified at day-0, day-2 and day-4 after a 10 km run. Ultrasound tissue characterisation (UTC) measures tendon structural integrity by classifying pixels as echo-type I, II, III or IV. Echo-type I has the most aligned collagen fibrils and IV has the least.

Results: Participants were 7 individuals with T1DM and 10 controls. All regularly ran distances greater than 5 km and VISA-A scores indicated good tendon function (T1DM = 94 ± 11, control = 94 ± 10). There were no diabetic complications and HbA1c was 8.7 ± 2.6 mmol/mol for T1DM and 5.3 ± 0.4 mmol/mol for control groups. Baseline tendon structure was similar in T1DM and control groups - UTC echo-types (I-IV) and anterior-posterior thickness were all p > 0.05. No response to load was seen in either T1DM or control group over the 4-days post exercise.

Conclusion: Active individuals with T1DM do not have a heightened Achilles tendon response to load, which suggests no increased risk of tendon injury. We cannot extrapolate these findings to sedentary individuals with T1DM.

No MeSH data available.


Related in: MedlinePlus