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Retinopathy of Prematurity among Very-Low-Birth-Weight Infants in Korea: Incidence, Treatment, and Risk Factors.

Hwang JH, Lee EH, Kim EA - J. Korean Med. Sci. (2015)

Bottom Line: The mean gestational age (GA) and birth weight (BW) were significantly lower and the prevalence rates of respiratory distress syndrome, patent ductus arteriosus (PDA), invasive ventilator duration, and sepsis were significantly higher in the VLBW infants with ROP than in those without ROP.In the multivariable logistic regression analysis, PDA (odd ratio [OR], 2.1; 95% confidence interval [CI], 1.11-3.79) and invasive ventilator duration (OR, 1.0; 95% CI, 1.00-1.02) were significant risk factors of ROP and ROP stage ≥ 3.In conclusion, the high incidence of ROP is associated with low GA and BW, and attempt to reduce the aforementioned risk factors could reduce the incidence of ROP stage ≥ 3 in VLBW infants.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea.

ABSTRACT
This study was conducted to describe the incidence, risk factors, and current treatment status of retinopathy of prematurity (ROP) in very-low-birth-weight (VLBW) infants registered in the Korean Neonatal Network database. Medical records of 2,009 VLBW infants born between January 2013 and June 2014 who underwent examination by an ophthalmologist were reviewed. The total incidence of ROP was 34.1%. Of the patients, 11.6% showed ROP stage ≥ 3 and 11.5% received treatment of VLBW. Among all infants who received treatment of ROP, 63.6% underwent operation only; 16.9%, anti-vascular endothelial growth factor (anti-VEGF) treatment only; and 19.5%, both operation and anti-VEGF treatment. The mean gestational age (GA) and birth weight (BW) were significantly lower and the prevalence rates of respiratory distress syndrome, patent ductus arteriosus (PDA), invasive ventilator duration, and sepsis were significantly higher in the VLBW infants with ROP than in those without ROP. In the multivariable logistic regression analysis, PDA (odd ratio [OR], 2.1; 95% confidence interval [CI], 1.11-3.79) and invasive ventilator duration (OR, 1.0; 95% CI, 1.00-1.02) were significant risk factors of ROP and ROP stage ≥ 3. In conclusion, the high incidence of ROP is associated with low GA and BW, and attempt to reduce the aforementioned risk factors could reduce the incidence of ROP stage ≥ 3 in VLBW infants.

No MeSH data available.


Related in: MedlinePlus

Schematic diagram of the enrolled patient in the study. ROP, retinopathy of prematurity; VLBW, very-low-birth-weight infant; VEGF, vascular endothelial growth factor.
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Figure 1: Schematic diagram of the enrolled patient in the study. ROP, retinopathy of prematurity; VLBW, very-low-birth-weight infant; VEGF, vascular endothelial growth factor.

Mentions: Among the 2,386 infants in 55 participating NICUs of the KNN (10), 377 were excluded because they died prior to ophthalmic examination (284 infants) or had not undergone oph-thalmic examination (93 infants). Of the 93 infants who had not undergone ophthalmic examination, 88 had not undergone ophthalmic examination during hospitalization and 5 were transferred to another hospital for reasons not related to ROP and had no available follow-up data regarding ROP. Finally, 2,009 infants were enrolled in this study (Fig. 1).


Retinopathy of Prematurity among Very-Low-Birth-Weight Infants in Korea: Incidence, Treatment, and Risk Factors.

Hwang JH, Lee EH, Kim EA - J. Korean Med. Sci. (2015)

Schematic diagram of the enrolled patient in the study. ROP, retinopathy of prematurity; VLBW, very-low-birth-weight infant; VEGF, vascular endothelial growth factor.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4641069&req=5

Figure 1: Schematic diagram of the enrolled patient in the study. ROP, retinopathy of prematurity; VLBW, very-low-birth-weight infant; VEGF, vascular endothelial growth factor.
Mentions: Among the 2,386 infants in 55 participating NICUs of the KNN (10), 377 were excluded because they died prior to ophthalmic examination (284 infants) or had not undergone oph-thalmic examination (93 infants). Of the 93 infants who had not undergone ophthalmic examination, 88 had not undergone ophthalmic examination during hospitalization and 5 were transferred to another hospital for reasons not related to ROP and had no available follow-up data regarding ROP. Finally, 2,009 infants were enrolled in this study (Fig. 1).

Bottom Line: The mean gestational age (GA) and birth weight (BW) were significantly lower and the prevalence rates of respiratory distress syndrome, patent ductus arteriosus (PDA), invasive ventilator duration, and sepsis were significantly higher in the VLBW infants with ROP than in those without ROP.In the multivariable logistic regression analysis, PDA (odd ratio [OR], 2.1; 95% confidence interval [CI], 1.11-3.79) and invasive ventilator duration (OR, 1.0; 95% CI, 1.00-1.02) were significant risk factors of ROP and ROP stage ≥ 3.In conclusion, the high incidence of ROP is associated with low GA and BW, and attempt to reduce the aforementioned risk factors could reduce the incidence of ROP stage ≥ 3 in VLBW infants.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea.

ABSTRACT
This study was conducted to describe the incidence, risk factors, and current treatment status of retinopathy of prematurity (ROP) in very-low-birth-weight (VLBW) infants registered in the Korean Neonatal Network database. Medical records of 2,009 VLBW infants born between January 2013 and June 2014 who underwent examination by an ophthalmologist were reviewed. The total incidence of ROP was 34.1%. Of the patients, 11.6% showed ROP stage ≥ 3 and 11.5% received treatment of VLBW. Among all infants who received treatment of ROP, 63.6% underwent operation only; 16.9%, anti-vascular endothelial growth factor (anti-VEGF) treatment only; and 19.5%, both operation and anti-VEGF treatment. The mean gestational age (GA) and birth weight (BW) were significantly lower and the prevalence rates of respiratory distress syndrome, patent ductus arteriosus (PDA), invasive ventilator duration, and sepsis were significantly higher in the VLBW infants with ROP than in those without ROP. In the multivariable logistic regression analysis, PDA (odd ratio [OR], 2.1; 95% confidence interval [CI], 1.11-3.79) and invasive ventilator duration (OR, 1.0; 95% CI, 1.00-1.02) were significant risk factors of ROP and ROP stage ≥ 3. In conclusion, the high incidence of ROP is associated with low GA and BW, and attempt to reduce the aforementioned risk factors could reduce the incidence of ROP stage ≥ 3 in VLBW infants.

No MeSH data available.


Related in: MedlinePlus