Limits...
Intraventricular Hemorrhage and Post Hemorrhagic Hydrocephalus among Very-Low-Birth-Weight Infants in Korea.

Ahn SY, Shim SY, Sung IK - J. Korean Med. Sci. (2015)

Bottom Line: Overall, in the VLBW infants, the IVH-associated mortality rate was 1.0% (24/2,323).Only IVH grade severity was proven to be an associated with PHH development in infants with IVH grades 3-4.Further risk factor analyses or quality improvement studies to reduce IVH are warranted.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Here, we aimed to evaluate the incidence and mortality of intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus (PHH) among very-low-birth-weight (VLBW) infants in Korea and assess the associated factors of PHH. This cohort study used prospectively collected data from the Korean Neonatal Network (KNN). Among 2,386 VLBW infants in the KNN database born between January 2013 and June 2014, 63 infants who died without brain ultrasonography results were excluded. Maternal demographics and neonatal clinical characteristics were assessed. The overall incidence of IVH in all the VLBW infants was 42.2% (987 of 2,323), while those of IVH grade 1, 2, 3, and 4 were 25.1%, 7.0%, 4.8%, and 5.5%, respectively. The incidence and severity of IVH showed a negatively correlating trend with gestational age and birth weight. PHH developed in 0%, 3.5%, 36.1%, and 63.8% of the surviving infants with IVH grades 1, 2, 3, and 4, respectively. Overall, in the VLBW infants, the IVH-associated mortality rate was 1.0% (24/2,323). Only IVH grade severity was proven to be an associated with PHH development in infants with IVH grades 3-4. This is the first Korean national report of IVH and PHH incidences in VLBW infants. Further risk factor analyses or quality improvement studies to reduce IVH are warranted.

No MeSH data available.


Related in: MedlinePlus

Incidence of intraventricular hemorrhage (IVH) according to gestational age (GA) (A) and birth weight (BW) (B). The proportions of infants with grades 1, 2, 3, and 4 IVH and without IVH are presented according to GA and BW.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4641064&req=5

Figure 1: Incidence of intraventricular hemorrhage (IVH) according to gestational age (GA) (A) and birth weight (BW) (B). The proportions of infants with grades 1, 2, 3, and 4 IVH and without IVH are presented according to GA and BW.

Mentions: A total of 2,386 VLBW infants were enrolled in the KNN registry during the study period. Of these infants, 2,323 with documented BUS were included in the analysis. The overall incidence of IVH in the VLBW infants registered in the KNN was 42.5% (987 of 2,323) (Table 1). Severe (grade 3-4) IVH occurred in 10.3% (240 of 2,323) of VLBW infants (Table 1). Among infants with any grade IVH, the incidence of grade 1, 2, 3, and 4 disease was 59.2% (584), 16.5% (163), 11.3% (112), and 13.0% (128), respectively. Fig. 1 shows the gestational age- and birth weight-dependent incidence of IVH by grade. Overall and severe (grade 3-4) IVH were more common in smaller and more immature infants (Table 2).


Intraventricular Hemorrhage and Post Hemorrhagic Hydrocephalus among Very-Low-Birth-Weight Infants in Korea.

Ahn SY, Shim SY, Sung IK - J. Korean Med. Sci. (2015)

Incidence of intraventricular hemorrhage (IVH) according to gestational age (GA) (A) and birth weight (BW) (B). The proportions of infants with grades 1, 2, 3, and 4 IVH and without IVH are presented according to GA and BW.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4641064&req=5

Figure 1: Incidence of intraventricular hemorrhage (IVH) according to gestational age (GA) (A) and birth weight (BW) (B). The proportions of infants with grades 1, 2, 3, and 4 IVH and without IVH are presented according to GA and BW.
Mentions: A total of 2,386 VLBW infants were enrolled in the KNN registry during the study period. Of these infants, 2,323 with documented BUS were included in the analysis. The overall incidence of IVH in the VLBW infants registered in the KNN was 42.5% (987 of 2,323) (Table 1). Severe (grade 3-4) IVH occurred in 10.3% (240 of 2,323) of VLBW infants (Table 1). Among infants with any grade IVH, the incidence of grade 1, 2, 3, and 4 disease was 59.2% (584), 16.5% (163), 11.3% (112), and 13.0% (128), respectively. Fig. 1 shows the gestational age- and birth weight-dependent incidence of IVH by grade. Overall and severe (grade 3-4) IVH were more common in smaller and more immature infants (Table 2).

Bottom Line: Overall, in the VLBW infants, the IVH-associated mortality rate was 1.0% (24/2,323).Only IVH grade severity was proven to be an associated with PHH development in infants with IVH grades 3-4.Further risk factor analyses or quality improvement studies to reduce IVH are warranted.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Here, we aimed to evaluate the incidence and mortality of intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus (PHH) among very-low-birth-weight (VLBW) infants in Korea and assess the associated factors of PHH. This cohort study used prospectively collected data from the Korean Neonatal Network (KNN). Among 2,386 VLBW infants in the KNN database born between January 2013 and June 2014, 63 infants who died without brain ultrasonography results were excluded. Maternal demographics and neonatal clinical characteristics were assessed. The overall incidence of IVH in all the VLBW infants was 42.2% (987 of 2,323), while those of IVH grade 1, 2, 3, and 4 were 25.1%, 7.0%, 4.8%, and 5.5%, respectively. The incidence and severity of IVH showed a negatively correlating trend with gestational age and birth weight. PHH developed in 0%, 3.5%, 36.1%, and 63.8% of the surviving infants with IVH grades 1, 2, 3, and 4, respectively. Overall, in the VLBW infants, the IVH-associated mortality rate was 1.0% (24/2,323). Only IVH grade severity was proven to be an associated with PHH development in infants with IVH grades 3-4. This is the first Korean national report of IVH and PHH incidences in VLBW infants. Further risk factor analyses or quality improvement studies to reduce IVH are warranted.

No MeSH data available.


Related in: MedlinePlus