Limits...
Dispersal of Engineered Male Aedes aegypti Mosquitoes.

Winskill P, Carvalho DO, Capurro ML, Alphey L, Donnelly CA, McKemey AR - PLoS Negl Trop Dis (2015)

Bottom Line: Dispersal kernels embedded within a generalized linear model framework were used to analyse data collected from three large scale mark release recapture studies.We parameterised dispersal kernels and estimated the mean distance travelled for insects in Brazil: 52.8m (95% CI: 49.9m, 56.8m) and Malaysia: 58.0m (95% CI: 51.1m, 71.0m).The comparative analysis indicates that despite differing environments and recapture rates, key features of the insects' dispersal kernels are conserved across the two studies.

View Article: PubMed Central - PubMed

Affiliation: Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom.

ABSTRACT

Background: Aedes aegypti, the principal vector of dengue fever, have been genetically engineered for use in a sterile insect control programme. To improve our understanding of the dispersal ecology of mosquitoes and to inform appropriate release strategies of 'genetically sterile' male Aedes aegypti detailed knowledge of the dispersal ability of the released insects is needed.

Methodology/principal findings: The dispersal ability of released 'genetically sterile' male Aedes aegypti at a field site in Brazil has been estimated. Dispersal kernels embedded within a generalized linear model framework were used to analyse data collected from three large scale mark release recapture studies. The methodology has been applied to previously published dispersal data to compare the dispersal ability of 'genetically sterile' male Aedes aegypti in contrasting environments. We parameterised dispersal kernels and estimated the mean distance travelled for insects in Brazil: 52.8m (95% CI: 49.9m, 56.8m) and Malaysia: 58.0m (95% CI: 51.1m, 71.0m).

Conclusions/significance: Our results provide specific, detailed estimates of the dispersal characteristics of released 'genetically sterile' male Aedes aegypti in the field. The comparative analysis indicates that despite differing environments and recapture rates, key features of the insects' dispersal kernels are conserved across the two studies. The results can be used to inform both risk assessments and release programmes using 'genetically sterile' male Aedes aegypti.

No MeSH data available.


Related in: MedlinePlus

Recaptures for three MRR experiments at the field site in Brazil.Numbered squares represent the two release points for MRR experiments. Coloured circles indicate the location and size of recaptures for three separate MRR releases (insects marked with red, yellow and blue fluorescent powder).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4640874&req=5

pntd.0004156.g003: Recaptures for three MRR experiments at the field site in Brazil.Numbered squares represent the two release points for MRR experiments. Coloured circles indicate the location and size of recaptures for three separate MRR releases (insects marked with red, yellow and blue fluorescent powder).

Mentions: Recaptures for the three MRR experiments are summarised in Table 1. The locations of recaptures are shown in Fig 3. The mean count of recaptured marked males (the response), per sample, per day was 0.077 (variance = 0.73). Over the recapture period the maximum daily temperature ranged between 25.4°C-34.6°C and the maximum relative humidity between 66%-92%.


Dispersal of Engineered Male Aedes aegypti Mosquitoes.

Winskill P, Carvalho DO, Capurro ML, Alphey L, Donnelly CA, McKemey AR - PLoS Negl Trop Dis (2015)

Recaptures for three MRR experiments at the field site in Brazil.Numbered squares represent the two release points for MRR experiments. Coloured circles indicate the location and size of recaptures for three separate MRR releases (insects marked with red, yellow and blue fluorescent powder).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4640874&req=5

pntd.0004156.g003: Recaptures for three MRR experiments at the field site in Brazil.Numbered squares represent the two release points for MRR experiments. Coloured circles indicate the location and size of recaptures for three separate MRR releases (insects marked with red, yellow and blue fluorescent powder).
Mentions: Recaptures for the three MRR experiments are summarised in Table 1. The locations of recaptures are shown in Fig 3. The mean count of recaptured marked males (the response), per sample, per day was 0.077 (variance = 0.73). Over the recapture period the maximum daily temperature ranged between 25.4°C-34.6°C and the maximum relative humidity between 66%-92%.

Bottom Line: Dispersal kernels embedded within a generalized linear model framework were used to analyse data collected from three large scale mark release recapture studies.We parameterised dispersal kernels and estimated the mean distance travelled for insects in Brazil: 52.8m (95% CI: 49.9m, 56.8m) and Malaysia: 58.0m (95% CI: 51.1m, 71.0m).The comparative analysis indicates that despite differing environments and recapture rates, key features of the insects' dispersal kernels are conserved across the two studies.

View Article: PubMed Central - PubMed

Affiliation: Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom.

ABSTRACT

Background: Aedes aegypti, the principal vector of dengue fever, have been genetically engineered for use in a sterile insect control programme. To improve our understanding of the dispersal ecology of mosquitoes and to inform appropriate release strategies of 'genetically sterile' male Aedes aegypti detailed knowledge of the dispersal ability of the released insects is needed.

Methodology/principal findings: The dispersal ability of released 'genetically sterile' male Aedes aegypti at a field site in Brazil has been estimated. Dispersal kernels embedded within a generalized linear model framework were used to analyse data collected from three large scale mark release recapture studies. The methodology has been applied to previously published dispersal data to compare the dispersal ability of 'genetically sterile' male Aedes aegypti in contrasting environments. We parameterised dispersal kernels and estimated the mean distance travelled for insects in Brazil: 52.8m (95% CI: 49.9m, 56.8m) and Malaysia: 58.0m (95% CI: 51.1m, 71.0m).

Conclusions/significance: Our results provide specific, detailed estimates of the dispersal characteristics of released 'genetically sterile' male Aedes aegypti in the field. The comparative analysis indicates that despite differing environments and recapture rates, key features of the insects' dispersal kernels are conserved across the two studies. The results can be used to inform both risk assessments and release programmes using 'genetically sterile' male Aedes aegypti.

No MeSH data available.


Related in: MedlinePlus