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Simultaneous [18F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer.

Brandmaier P, Purz S, Bremicker K, Höckel M, Barthel H, Kluge R, Kahn T, Sabri O, Stumpp P - PLoS ONE (2015)

Bottom Line: Previous non-simultaneous PET/MR studies have shown heterogeneous results about the correlation between standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs).We found a significant inverse correlation between SUVmax and ADCmin (r = -0.532, p = 0.05) in primary tumors as well as in primary metastases (r = -0.362, p = 0.05) and between SUVmean and ADCmin (r = -0.403, p = 0.03).Associations for recurrent metastases were not significant (p>0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.

ABSTRACT

Objectives: Previous non-simultaneous PET/MR studies have shown heterogeneous results about the correlation between standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs). The aim of this study was to investigate correlations in patients with primary and recurrent tumors using a simultaneous PET/MRI system which could lead to a better understanding of tumor biology and might play a role in early response assessment.

Methods: We included 31 patients with histologically confirmed primary (n = 14) or recurrent cervical cancer (n = 17) who underwent simultaneous whole-body 18F-FDG-PET/MRI comprising DWI. Image analysis was performed by a radiologist and a nuclear physician who identified tumor margins and quantified ADC and SUV. Pearson correlations were calculated to investigate the association between ADC and SUV.

Results: 92 lesions were detected. We found a significant inverse correlation between SUVmax and ADCmin (r = -0.532, p = 0.05) in primary tumors as well as in primary metastases (r = -0.362, p = 0.05) and between SUVmean and ADCmin (r = -0.403, p = 0.03). In recurrent local tumors we found correlations for SUVmax and ADCmin (r = -0.747, p = 0.002) and SUVmean and ADCmin (r = -0.773, p = 0.001). Associations for recurrent metastases were not significant (p>0.05).

Conclusions: Our study demonstrates the feasibility of fast and reliable measurement of SUV and ADC with simultaneous PET/MRI. In patients with cervical cancer we found significant inverse correlations for SUV and ADC which could play a major role for further tumor characterization and therapy decisions.

No MeSH data available.


Related in: MedlinePlus

Absolute SUV of primary and recurrent cervical cancer/metastasis presented through error bars.
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pone.0141684.g003: Absolute SUV of primary and recurrent cervical cancer/metastasis presented through error bars.

Mentions: All 31 patients successfully completed the whole-body PET/MRI examinations without any relevant side effects in an appropriate examination time of 30 minutes on average for whole body imaging. A total of 92 cancerous lesions were detected by simultaneous PET/MRI: primary tumors (n = 14), primary metastasis (n = 29 lymph nodes) recurrent tumors (n = 14) or recurrent metastasis (n = 35; 34 lymph nodes and 1 liver metastasis). Values for SUV and ADC (see S1 File) of these lesions are demonstrated in Figs 3 and 4 respectively. For primary tumors, mean values were 24.8±14.2 for SUVmax and 13.1±8.7 for SUVmean, for primary metastasis 13.5±6.6 for SUVmax and 8.0±4.3 for SUVmean, for recurrent tumors 17.4±5.7 for SUVmax and 10.0±3.5 for SUVmean and for recurrent metastasis 14.5 ± 5.8 for SUVmax and 8.3±3.6 for SUVmean. There was a significant difference between SUVmax of primary tumors and SUVmax of recurrent tumors (p<0.05) but not between primary and recurrent metastases (p = 0.39).


Simultaneous [18F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer.

Brandmaier P, Purz S, Bremicker K, Höckel M, Barthel H, Kluge R, Kahn T, Sabri O, Stumpp P - PLoS ONE (2015)

Absolute SUV of primary and recurrent cervical cancer/metastasis presented through error bars.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4638340&req=5

pone.0141684.g003: Absolute SUV of primary and recurrent cervical cancer/metastasis presented through error bars.
Mentions: All 31 patients successfully completed the whole-body PET/MRI examinations without any relevant side effects in an appropriate examination time of 30 minutes on average for whole body imaging. A total of 92 cancerous lesions were detected by simultaneous PET/MRI: primary tumors (n = 14), primary metastasis (n = 29 lymph nodes) recurrent tumors (n = 14) or recurrent metastasis (n = 35; 34 lymph nodes and 1 liver metastasis). Values for SUV and ADC (see S1 File) of these lesions are demonstrated in Figs 3 and 4 respectively. For primary tumors, mean values were 24.8±14.2 for SUVmax and 13.1±8.7 for SUVmean, for primary metastasis 13.5±6.6 for SUVmax and 8.0±4.3 for SUVmean, for recurrent tumors 17.4±5.7 for SUVmax and 10.0±3.5 for SUVmean and for recurrent metastasis 14.5 ± 5.8 for SUVmax and 8.3±3.6 for SUVmean. There was a significant difference between SUVmax of primary tumors and SUVmax of recurrent tumors (p<0.05) but not between primary and recurrent metastases (p = 0.39).

Bottom Line: Previous non-simultaneous PET/MR studies have shown heterogeneous results about the correlation between standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs).We found a significant inverse correlation between SUVmax and ADCmin (r = -0.532, p = 0.05) in primary tumors as well as in primary metastases (r = -0.362, p = 0.05) and between SUVmean and ADCmin (r = -0.403, p = 0.03).Associations for recurrent metastases were not significant (p>0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.

ABSTRACT

Objectives: Previous non-simultaneous PET/MR studies have shown heterogeneous results about the correlation between standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs). The aim of this study was to investigate correlations in patients with primary and recurrent tumors using a simultaneous PET/MRI system which could lead to a better understanding of tumor biology and might play a role in early response assessment.

Methods: We included 31 patients with histologically confirmed primary (n = 14) or recurrent cervical cancer (n = 17) who underwent simultaneous whole-body 18F-FDG-PET/MRI comprising DWI. Image analysis was performed by a radiologist and a nuclear physician who identified tumor margins and quantified ADC and SUV. Pearson correlations were calculated to investigate the association between ADC and SUV.

Results: 92 lesions were detected. We found a significant inverse correlation between SUVmax and ADCmin (r = -0.532, p = 0.05) in primary tumors as well as in primary metastases (r = -0.362, p = 0.05) and between SUVmean and ADCmin (r = -0.403, p = 0.03). In recurrent local tumors we found correlations for SUVmax and ADCmin (r = -0.747, p = 0.002) and SUVmean and ADCmin (r = -0.773, p = 0.001). Associations for recurrent metastases were not significant (p>0.05).

Conclusions: Our study demonstrates the feasibility of fast and reliable measurement of SUV and ADC with simultaneous PET/MRI. In patients with cervical cancer we found significant inverse correlations for SUV and ADC which could play a major role for further tumor characterization and therapy decisions.

No MeSH data available.


Related in: MedlinePlus