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Simultaneous [18F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer.

Brandmaier P, Purz S, Bremicker K, Höckel M, Barthel H, Kluge R, Kahn T, Sabri O, Stumpp P - PLoS ONE (2015)

Bottom Line: Previous non-simultaneous PET/MR studies have shown heterogeneous results about the correlation between standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs).We found a significant inverse correlation between SUVmax and ADCmin (r = -0.532, p = 0.05) in primary tumors as well as in primary metastases (r = -0.362, p = 0.05) and between SUVmean and ADCmin (r = -0.403, p = 0.03).Associations for recurrent metastases were not significant (p>0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.

ABSTRACT

Objectives: Previous non-simultaneous PET/MR studies have shown heterogeneous results about the correlation between standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs). The aim of this study was to investigate correlations in patients with primary and recurrent tumors using a simultaneous PET/MRI system which could lead to a better understanding of tumor biology and might play a role in early response assessment.

Methods: We included 31 patients with histologically confirmed primary (n = 14) or recurrent cervical cancer (n = 17) who underwent simultaneous whole-body 18F-FDG-PET/MRI comprising DWI. Image analysis was performed by a radiologist and a nuclear physician who identified tumor margins and quantified ADC and SUV. Pearson correlations were calculated to investigate the association between ADC and SUV.

Results: 92 lesions were detected. We found a significant inverse correlation between SUVmax and ADCmin (r = -0.532, p = 0.05) in primary tumors as well as in primary metastases (r = -0.362, p = 0.05) and between SUVmean and ADCmin (r = -0.403, p = 0.03). In recurrent local tumors we found correlations for SUVmax and ADCmin (r = -0.747, p = 0.002) and SUVmean and ADCmin (r = -0.773, p = 0.001). Associations for recurrent metastases were not significant (p>0.05).

Conclusions: Our study demonstrates the feasibility of fast and reliable measurement of SUV and ADC with simultaneous PET/MRI. In patients with cervical cancer we found significant inverse correlations for SUV and ADC which could play a major role for further tumor characterization and therapy decisions.

No MeSH data available.


Related in: MedlinePlus

56-year old female with histology proven recurrent lymph node metastasis of cervical cancer diagnosed 3 years before.Pre-operative simultaneous 18F-FDG-PET/MRI (A) and T2-weighted MR imaging (B) show a hypermetabolic left paraaortal metastastic lymph node (arrow) with corresponding diffusion-restriction in DWI (C) and ADC-map (D).
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pone.0141684.g001: 56-year old female with histology proven recurrent lymph node metastasis of cervical cancer diagnosed 3 years before.Pre-operative simultaneous 18F-FDG-PET/MRI (A) and T2-weighted MR imaging (B) show a hypermetabolic left paraaortal metastastic lymph node (arrow) with corresponding diffusion-restriction in DWI (C) and ADC-map (D).

Mentions: An experienced radiological (6 years experience in gynaecological imaging) and nuclear medicine reader (7 years experience in oncological image interpretation) analyzed the images using dedicated viewing software (Syngo.via®; Siemens, Healthcare Sector, Erlangen, Germany). Lesions with focal uptake greater than the surrounding tissue (based on visual qualitative analysis) were considered as suspicious for malignancy (Fig 1).


Simultaneous [18F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer.

Brandmaier P, Purz S, Bremicker K, Höckel M, Barthel H, Kluge R, Kahn T, Sabri O, Stumpp P - PLoS ONE (2015)

56-year old female with histology proven recurrent lymph node metastasis of cervical cancer diagnosed 3 years before.Pre-operative simultaneous 18F-FDG-PET/MRI (A) and T2-weighted MR imaging (B) show a hypermetabolic left paraaortal metastastic lymph node (arrow) with corresponding diffusion-restriction in DWI (C) and ADC-map (D).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4638340&req=5

pone.0141684.g001: 56-year old female with histology proven recurrent lymph node metastasis of cervical cancer diagnosed 3 years before.Pre-operative simultaneous 18F-FDG-PET/MRI (A) and T2-weighted MR imaging (B) show a hypermetabolic left paraaortal metastastic lymph node (arrow) with corresponding diffusion-restriction in DWI (C) and ADC-map (D).
Mentions: An experienced radiological (6 years experience in gynaecological imaging) and nuclear medicine reader (7 years experience in oncological image interpretation) analyzed the images using dedicated viewing software (Syngo.via®; Siemens, Healthcare Sector, Erlangen, Germany). Lesions with focal uptake greater than the surrounding tissue (based on visual qualitative analysis) were considered as suspicious for malignancy (Fig 1).

Bottom Line: Previous non-simultaneous PET/MR studies have shown heterogeneous results about the correlation between standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs).We found a significant inverse correlation between SUVmax and ADCmin (r = -0.532, p = 0.05) in primary tumors as well as in primary metastases (r = -0.362, p = 0.05) and between SUVmean and ADCmin (r = -0.403, p = 0.03).Associations for recurrent metastases were not significant (p>0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.

ABSTRACT

Objectives: Previous non-simultaneous PET/MR studies have shown heterogeneous results about the correlation between standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs). The aim of this study was to investigate correlations in patients with primary and recurrent tumors using a simultaneous PET/MRI system which could lead to a better understanding of tumor biology and might play a role in early response assessment.

Methods: We included 31 patients with histologically confirmed primary (n = 14) or recurrent cervical cancer (n = 17) who underwent simultaneous whole-body 18F-FDG-PET/MRI comprising DWI. Image analysis was performed by a radiologist and a nuclear physician who identified tumor margins and quantified ADC and SUV. Pearson correlations were calculated to investigate the association between ADC and SUV.

Results: 92 lesions were detected. We found a significant inverse correlation between SUVmax and ADCmin (r = -0.532, p = 0.05) in primary tumors as well as in primary metastases (r = -0.362, p = 0.05) and between SUVmean and ADCmin (r = -0.403, p = 0.03). In recurrent local tumors we found correlations for SUVmax and ADCmin (r = -0.747, p = 0.002) and SUVmean and ADCmin (r = -0.773, p = 0.001). Associations for recurrent metastases were not significant (p>0.05).

Conclusions: Our study demonstrates the feasibility of fast and reliable measurement of SUV and ADC with simultaneous PET/MRI. In patients with cervical cancer we found significant inverse correlations for SUV and ADC which could play a major role for further tumor characterization and therapy decisions.

No MeSH data available.


Related in: MedlinePlus