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Human leukocyte antigen class II DRB1*1302 allele protects against cervical cancer: At which step of multistage carcinogenesis?

Matsumoto K, Maeda H, Oki A, Takatsuka N, Yasugi T, Furuta R, Hirata R, Mitsuhashi A, Kawana K, Fujii T, Iwata T, Hirai Y, Yokoyama M, Yaegashi N, Watanabe Y, Nagai Y, Yoshikawa H, Japan HPV and Cervical Cancer (JHACC) Study Gro - Cancer Sci. (2015)

Bottom Line: HLA class II DRB1*1302 allele frequency was similar between women with NL (11.7%) and CIN1 (11.9%), but significantly decreased to 5.2% for CIN2/3 and 5.8% for ICC (P = 0.0003).Correction for multiple testing did not change this finding.In conclusion, the two different types of analysis in this single study showed the protective effect of the DRB1*1302 allele against progression from CIN1 to CIN2/3.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, Japan.

No MeSH data available.


Related in: MedlinePlus

Cumulative risks of cervical intraepithelial neoplasia grade 3 within 10 years in relation to human leukocyte antigen class II polymorphisms. A Kaplan–Meier plot was used to estimate the cumulative 10-year probabilities of progression to cervical intraepithelial neoplasia grade 3 among women with low-grade squamous intraepithelial lesion cytology for selected human leukocyte antigen class II alleles: DRB1*0901 (a), DRB1*1302 (b), DRB1*1501 (c), and DQB1*03 alleles (d). P-values were calculated using the log–rank test.
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fig01: Cumulative risks of cervical intraepithelial neoplasia grade 3 within 10 years in relation to human leukocyte antigen class II polymorphisms. A Kaplan–Meier plot was used to estimate the cumulative 10-year probabilities of progression to cervical intraepithelial neoplasia grade 3 among women with low-grade squamous intraepithelial lesion cytology for selected human leukocyte antigen class II alleles: DRB1*0901 (a), DRB1*1302 (b), DRB1*1501 (c), and DQB1*03 alleles (d). P-values were calculated using the log–rank test.

Mentions: Unlike the cross-sectional analysis results, DRB1*0901 was not associated with progression to CIN3 in the prospective analysis (P = 0.88; Fig.1a). Adjustment for age, CIN grade at the time of entry, HPV risk category, parity, smoking status, OC use, number of lifetime sexual partners, and age at first sexual intercourse did not change this finding (P = 0.71; Table3).


Human leukocyte antigen class II DRB1*1302 allele protects against cervical cancer: At which step of multistage carcinogenesis?

Matsumoto K, Maeda H, Oki A, Takatsuka N, Yasugi T, Furuta R, Hirata R, Mitsuhashi A, Kawana K, Fujii T, Iwata T, Hirai Y, Yokoyama M, Yaegashi N, Watanabe Y, Nagai Y, Yoshikawa H, Japan HPV and Cervical Cancer (JHACC) Study Gro - Cancer Sci. (2015)

Cumulative risks of cervical intraepithelial neoplasia grade 3 within 10 years in relation to human leukocyte antigen class II polymorphisms. A Kaplan–Meier plot was used to estimate the cumulative 10-year probabilities of progression to cervical intraepithelial neoplasia grade 3 among women with low-grade squamous intraepithelial lesion cytology for selected human leukocyte antigen class II alleles: DRB1*0901 (a), DRB1*1302 (b), DRB1*1501 (c), and DQB1*03 alleles (d). P-values were calculated using the log–rank test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4638013&req=5

fig01: Cumulative risks of cervical intraepithelial neoplasia grade 3 within 10 years in relation to human leukocyte antigen class II polymorphisms. A Kaplan–Meier plot was used to estimate the cumulative 10-year probabilities of progression to cervical intraepithelial neoplasia grade 3 among women with low-grade squamous intraepithelial lesion cytology for selected human leukocyte antigen class II alleles: DRB1*0901 (a), DRB1*1302 (b), DRB1*1501 (c), and DQB1*03 alleles (d). P-values were calculated using the log–rank test.
Mentions: Unlike the cross-sectional analysis results, DRB1*0901 was not associated with progression to CIN3 in the prospective analysis (P = 0.88; Fig.1a). Adjustment for age, CIN grade at the time of entry, HPV risk category, parity, smoking status, OC use, number of lifetime sexual partners, and age at first sexual intercourse did not change this finding (P = 0.71; Table3).

Bottom Line: HLA class II DRB1*1302 allele frequency was similar between women with NL (11.7%) and CIN1 (11.9%), but significantly decreased to 5.2% for CIN2/3 and 5.8% for ICC (P = 0.0003).Correction for multiple testing did not change this finding.In conclusion, the two different types of analysis in this single study showed the protective effect of the DRB1*1302 allele against progression from CIN1 to CIN2/3.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, Japan.

No MeSH data available.


Related in: MedlinePlus