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Hematopoietic pre-B cell leukemia transcription factor interacting protein is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, migration, and invasion.

Feng Y, Li L, Zhang X, Zhang Y, Liang Y, Lv J, Fan Z, Guo J, Hong T, Ji B, Ji Q, Mei G, Ding L, Zhang S, Xu X, Ye Q - Cancer Sci. (2015)

Bottom Line: In GC patients, HPIP positively associates with tumor size and nodal metastasis, and negatively associates with tumor differentiation.Hematopoietic pre-B cell leukemia transcription factor interacting protein increases GC cell proliferation through activation of G1 /S and G2 /M cell cycle transitions, accompanied by a marked increase of the positive cell cycle regulators, including cyclin D1, cyclin A, and cyclin B1.These data underscore the critical role of HPIP in GC cell proliferation and progression and suggest that HPIP inhibition may be a useful therapeutic strategy for GC treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.

No MeSH data available.


Related in: MedlinePlus

Knockdown of hematopoietic pre-B-cell leukemia transcription factor interacting protein (HPIP) suppresses gastric cancer cell growth in nude mice. (a) BGC823 cells stably infected with HPIP shRNA or control shRNA cells were injected into nude mice. At the indicated times, tumors were measured with Vernier calipers (mean ± SD; n = 7). **P < 0.01 versus corresponding control shRNA. (b) Immunoblot analysis of representative excised tumor from (a).
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fig06: Knockdown of hematopoietic pre-B-cell leukemia transcription factor interacting protein (HPIP) suppresses gastric cancer cell growth in nude mice. (a) BGC823 cells stably infected with HPIP shRNA or control shRNA cells were injected into nude mice. At the indicated times, tumors were measured with Vernier calipers (mean ± SD; n = 7). **P < 0.01 versus corresponding control shRNA. (b) Immunoblot analysis of representative excised tumor from (a).

Mentions: Finally, we investigated the effect of HPIP on GC cell growth in a mouse model. BGC823 cells stably infected with HPIP shRNA lentivirus or empty vector were inoculated s.c. in the dorsal skin fold of each nude mouse. As expected, knockdown of HPIP significantly suppressed the GC growth in nude mice (Fig. 6a), compared with the control shRNA group. In addition, the BGC823 tumors with HPIP shRNA showed decreased expression of HPIP, cyclins D1, A, and B1, and N-cadherin, and increased expression of E-cadherin (Fig. 6b).


Hematopoietic pre-B cell leukemia transcription factor interacting protein is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, migration, and invasion.

Feng Y, Li L, Zhang X, Zhang Y, Liang Y, Lv J, Fan Z, Guo J, Hong T, Ji B, Ji Q, Mei G, Ding L, Zhang S, Xu X, Ye Q - Cancer Sci. (2015)

Knockdown of hematopoietic pre-B-cell leukemia transcription factor interacting protein (HPIP) suppresses gastric cancer cell growth in nude mice. (a) BGC823 cells stably infected with HPIP shRNA or control shRNA cells were injected into nude mice. At the indicated times, tumors were measured with Vernier calipers (mean ± SD; n = 7). **P < 0.01 versus corresponding control shRNA. (b) Immunoblot analysis of representative excised tumor from (a).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4638003&req=5

fig06: Knockdown of hematopoietic pre-B-cell leukemia transcription factor interacting protein (HPIP) suppresses gastric cancer cell growth in nude mice. (a) BGC823 cells stably infected with HPIP shRNA or control shRNA cells were injected into nude mice. At the indicated times, tumors were measured with Vernier calipers (mean ± SD; n = 7). **P < 0.01 versus corresponding control shRNA. (b) Immunoblot analysis of representative excised tumor from (a).
Mentions: Finally, we investigated the effect of HPIP on GC cell growth in a mouse model. BGC823 cells stably infected with HPIP shRNA lentivirus or empty vector were inoculated s.c. in the dorsal skin fold of each nude mouse. As expected, knockdown of HPIP significantly suppressed the GC growth in nude mice (Fig. 6a), compared with the control shRNA group. In addition, the BGC823 tumors with HPIP shRNA showed decreased expression of HPIP, cyclins D1, A, and B1, and N-cadherin, and increased expression of E-cadherin (Fig. 6b).

Bottom Line: In GC patients, HPIP positively associates with tumor size and nodal metastasis, and negatively associates with tumor differentiation.Hematopoietic pre-B cell leukemia transcription factor interacting protein increases GC cell proliferation through activation of G1 /S and G2 /M cell cycle transitions, accompanied by a marked increase of the positive cell cycle regulators, including cyclin D1, cyclin A, and cyclin B1.These data underscore the critical role of HPIP in GC cell proliferation and progression and suggest that HPIP inhibition may be a useful therapeutic strategy for GC treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.

No MeSH data available.


Related in: MedlinePlus