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Novel nanosystem to enhance the antitumor activity of lapatinib in breast cancer treatment: Therapeutic efficacy evaluation.

Huo ZJ, Wang SJ, Wang ZQ, Zuo WS, Liu P, Pang B, Liu K - Cancer Sci. (2015)

Bottom Line: Pharmacokinetic data suggested that nanoparticles could significantly enhance the blood circulation time of LPT by reducing the uptake by a reticuloendothelial system (RES).Importantly, PLPT significantly reduced the tumor burden of cancerous mice and effectively controlled the tumor cell proliferation.TUNEL assay further showed a greater apoptosis of tumor tissues in the PLPT treated mice group.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Disease Center, Shandong Cancer Hospital & Institute, Jinan, China.

No MeSH data available.


Related in: MedlinePlus

Schematic presentation of preparation of polymer-lipid hybrid nanoparticles. Lapatinib was loaded in the hydrophobic core of the polymeric nanoparticle which was then coated by a mono-lipid layer.
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fig01: Schematic presentation of preparation of polymer-lipid hybrid nanoparticles. Lapatinib was loaded in the hydrophobic core of the polymeric nanoparticle which was then coated by a mono-lipid layer.

Mentions: In the present study, poly(lactide-co-glycolide)-d-a-tocopheryl polyethylene glycol 1000 succinate (PLGA–TPGS) copolymer was selected to form the polymeric NP (Fig.1). Whereas, PLGA is a biodegradable and biocompatible polymer and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) is a water-soluble derivative of natural vitamin E.21 PLGA was conjugated to TPGS in order to improve the mechanical strength of the overall copolymer and to improve the drug permeability in cancer cells. TPGS could enhance the absorption of the drug by inhibiting the P-glycoprotein mediated multidrug resistance in cancer cells. There are several reports of inhibitory effect of TPGS in cancer cells in in vitro and in vivo conditions.22


Novel nanosystem to enhance the antitumor activity of lapatinib in breast cancer treatment: Therapeutic efficacy evaluation.

Huo ZJ, Wang SJ, Wang ZQ, Zuo WS, Liu P, Pang B, Liu K - Cancer Sci. (2015)

Schematic presentation of preparation of polymer-lipid hybrid nanoparticles. Lapatinib was loaded in the hydrophobic core of the polymeric nanoparticle which was then coated by a mono-lipid layer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4637996&req=5

fig01: Schematic presentation of preparation of polymer-lipid hybrid nanoparticles. Lapatinib was loaded in the hydrophobic core of the polymeric nanoparticle which was then coated by a mono-lipid layer.
Mentions: In the present study, poly(lactide-co-glycolide)-d-a-tocopheryl polyethylene glycol 1000 succinate (PLGA–TPGS) copolymer was selected to form the polymeric NP (Fig.1). Whereas, PLGA is a biodegradable and biocompatible polymer and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) is a water-soluble derivative of natural vitamin E.21 PLGA was conjugated to TPGS in order to improve the mechanical strength of the overall copolymer and to improve the drug permeability in cancer cells. TPGS could enhance the absorption of the drug by inhibiting the P-glycoprotein mediated multidrug resistance in cancer cells. There are several reports of inhibitory effect of TPGS in cancer cells in in vitro and in vivo conditions.22

Bottom Line: Pharmacokinetic data suggested that nanoparticles could significantly enhance the blood circulation time of LPT by reducing the uptake by a reticuloendothelial system (RES).Importantly, PLPT significantly reduced the tumor burden of cancerous mice and effectively controlled the tumor cell proliferation.TUNEL assay further showed a greater apoptosis of tumor tissues in the PLPT treated mice group.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Disease Center, Shandong Cancer Hospital & Institute, Jinan, China.

No MeSH data available.


Related in: MedlinePlus