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Iodine-Supported Hip Implants: Short Term Clinical Results.

Kabata T, Maeda T, Kajino Y, Hasegawa K, Inoue D, Yamamoto T, Takagi T, Ohmori T, Tsuchiya H - Biomed Res Int (2015)

Bottom Line: No abnormalities of thyroid gland function were detected.Excellent bone ingrowth and ongrowth were found around prostheses.No cytotoxicity or adverse effects were detected.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8641, Japan.

ABSTRACT
We developed a new povidone iodine coating technology for titanium hip implants and performed a clinical trial to assess its usefulness in suppressing postoperative infection. Results indicate that iodine-supported titanium has favorable antibacterial activity, biocompatibility, and no cytotoxicity. Thirty joints in 28 patients were treated using iodine-supported implants. Fourteen joints were revision total hip arthroplasty (THA) after periprosthetic infection, 13 were primary THA for immunosuppressive conditions or pyogenic arthritis, and 3 were conversions from hemiarthroplasty to THA for immunosuppressive conditions. Two examinations were conducted sequentially until final follow-up: white blood cell (WBC) and C-reactive protein (CRP) were measured pre- and postoperatively and thyroid hormone levels in the blood were examined. The mean follow-up period was 33 months (14-78). There were no signs of infection in any patient at the last follow-up. WBC and CRP levels returned to normal within several weeks. No abnormalities of thyroid gland function were detected. Loosening of the implants did not occur in any patient. Excellent bone ingrowth and ongrowth were found around prostheses. No cytotoxicity or adverse effects were detected. These results suggest that iodine-supported THA implants can be highly effective in preventing and treating postoperative infections.

No MeSH data available.


Related in: MedlinePlus

The free triiodothyronine (FT3; pg/mL), free thyroxine (FT4; ng/dL), and thyroid-stimulating hormone (TSH; μIU/mL) levels were within the normal ranges during the study period.
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Related In: Results  -  Collection


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fig7: The free triiodothyronine (FT3; pg/mL), free thyroxine (FT4; ng/dL), and thyroid-stimulating hormone (TSH; μIU/mL) levels were within the normal ranges during the study period.

Mentions: In all cases, the preoperative FT3 (pg/mL), FT4 (ng/dL), and TSH levels (μIU/mL) were almost normal ranges (median 2.68 pg/mL, range 2.07–3.43; 1.14 ng/dL, range 0.8–1.42; 1.98 μIU/mL, range 0.3–8.54, resp.). One year postoperatively, the levels were still within the normal ranges (median 2.87 pg/mL, range 2.17–3.73; 1.14 ng/dL, range 0.81–1.59; 2.9 μIU/mL, range 0.86–19.9, resp.) (Figure 7). There was no case of thyroid gland malfunction with the use of iodine-supported implants.


Iodine-Supported Hip Implants: Short Term Clinical Results.

Kabata T, Maeda T, Kajino Y, Hasegawa K, Inoue D, Yamamoto T, Takagi T, Ohmori T, Tsuchiya H - Biomed Res Int (2015)

The free triiodothyronine (FT3; pg/mL), free thyroxine (FT4; ng/dL), and thyroid-stimulating hormone (TSH; μIU/mL) levels were within the normal ranges during the study period.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4637032&req=5

fig7: The free triiodothyronine (FT3; pg/mL), free thyroxine (FT4; ng/dL), and thyroid-stimulating hormone (TSH; μIU/mL) levels were within the normal ranges during the study period.
Mentions: In all cases, the preoperative FT3 (pg/mL), FT4 (ng/dL), and TSH levels (μIU/mL) were almost normal ranges (median 2.68 pg/mL, range 2.07–3.43; 1.14 ng/dL, range 0.8–1.42; 1.98 μIU/mL, range 0.3–8.54, resp.). One year postoperatively, the levels were still within the normal ranges (median 2.87 pg/mL, range 2.17–3.73; 1.14 ng/dL, range 0.81–1.59; 2.9 μIU/mL, range 0.86–19.9, resp.) (Figure 7). There was no case of thyroid gland malfunction with the use of iodine-supported implants.

Bottom Line: No abnormalities of thyroid gland function were detected.Excellent bone ingrowth and ongrowth were found around prostheses.No cytotoxicity or adverse effects were detected.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8641, Japan.

ABSTRACT
We developed a new povidone iodine coating technology for titanium hip implants and performed a clinical trial to assess its usefulness in suppressing postoperative infection. Results indicate that iodine-supported titanium has favorable antibacterial activity, biocompatibility, and no cytotoxicity. Thirty joints in 28 patients were treated using iodine-supported implants. Fourteen joints were revision total hip arthroplasty (THA) after periprosthetic infection, 13 were primary THA for immunosuppressive conditions or pyogenic arthritis, and 3 were conversions from hemiarthroplasty to THA for immunosuppressive conditions. Two examinations were conducted sequentially until final follow-up: white blood cell (WBC) and C-reactive protein (CRP) were measured pre- and postoperatively and thyroid hormone levels in the blood were examined. The mean follow-up period was 33 months (14-78). There were no signs of infection in any patient at the last follow-up. WBC and CRP levels returned to normal within several weeks. No abnormalities of thyroid gland function were detected. Loosening of the implants did not occur in any patient. Excellent bone ingrowth and ongrowth were found around prostheses. No cytotoxicity or adverse effects were detected. These results suggest that iodine-supported THA implants can be highly effective in preventing and treating postoperative infections.

No MeSH data available.


Related in: MedlinePlus