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Iodine-Supported Hip Implants: Short Term Clinical Results.

Kabata T, Maeda T, Kajino Y, Hasegawa K, Inoue D, Yamamoto T, Takagi T, Ohmori T, Tsuchiya H - Biomed Res Int (2015)

Bottom Line: No abnormalities of thyroid gland function were detected.Excellent bone ingrowth and ongrowth were found around prostheses.No cytotoxicity or adverse effects were detected.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8641, Japan.

ABSTRACT
We developed a new povidone iodine coating technology for titanium hip implants and performed a clinical trial to assess its usefulness in suppressing postoperative infection. Results indicate that iodine-supported titanium has favorable antibacterial activity, biocompatibility, and no cytotoxicity. Thirty joints in 28 patients were treated using iodine-supported implants. Fourteen joints were revision total hip arthroplasty (THA) after periprosthetic infection, 13 were primary THA for immunosuppressive conditions or pyogenic arthritis, and 3 were conversions from hemiarthroplasty to THA for immunosuppressive conditions. Two examinations were conducted sequentially until final follow-up: white blood cell (WBC) and C-reactive protein (CRP) were measured pre- and postoperatively and thyroid hormone levels in the blood were examined. The mean follow-up period was 33 months (14-78). There were no signs of infection in any patient at the last follow-up. WBC and CRP levels returned to normal within several weeks. No abnormalities of thyroid gland function were detected. Loosening of the implants did not occur in any patient. Excellent bone ingrowth and ongrowth were found around prostheses. No cytotoxicity or adverse effects were detected. These results suggest that iodine-supported THA implants can be highly effective in preventing and treating postoperative infections.

No MeSH data available.


Related in: MedlinePlus

Electron micrograph of the oxide layer: more than 50,000 pores/mm2.
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fig2: Electron micrograph of the oxide layer: more than 50,000 pores/mm2.

Mentions: In all cases in this series we used titanium hip implants with iodine-containing surfaces (Figure 1). Two weeks before surgery, all implants were selected according to the preoperative plan using a 3D templating system (ZedHip, Lexi Co., Tokyo, Japan), and iodine-containing surface treatments were applied by the Chiba Institute of Technology (Narashino, Japan) using the technique described by Hashimoto et al. [13]. The thickness of the anodic oxide film was 5–10 μm with >50,000 pores/mm2, with the capacity to support 10–12 μg/cm2 of iodine (Figure 2) [11, 12]. Twenty-six acetabular sockets (Trilogy, Zimmer, Warsaw, USA; Converge, Zimmer, Warsaw, USA; Tritanium, Stryker, Mahwah, USA), 4 acetabular reinforcement cages (KT-plate, Kyocera, Osaka, Japan; Contour, Smith & Nephew, Memphis, USA), and 26 femoral stems (Allo-classic, Zimmer, Warsaw, USA; CLS, Zimmer, Warsaw, USA; Mayo conservative hip, Zimmer, Warsaw, USA; S-ROM-A, DePuy-Synthes Warsaw, USA) were iodine-supported and implanted.


Iodine-Supported Hip Implants: Short Term Clinical Results.

Kabata T, Maeda T, Kajino Y, Hasegawa K, Inoue D, Yamamoto T, Takagi T, Ohmori T, Tsuchiya H - Biomed Res Int (2015)

Electron micrograph of the oxide layer: more than 50,000 pores/mm2.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4637032&req=5

fig2: Electron micrograph of the oxide layer: more than 50,000 pores/mm2.
Mentions: In all cases in this series we used titanium hip implants with iodine-containing surfaces (Figure 1). Two weeks before surgery, all implants were selected according to the preoperative plan using a 3D templating system (ZedHip, Lexi Co., Tokyo, Japan), and iodine-containing surface treatments were applied by the Chiba Institute of Technology (Narashino, Japan) using the technique described by Hashimoto et al. [13]. The thickness of the anodic oxide film was 5–10 μm with >50,000 pores/mm2, with the capacity to support 10–12 μg/cm2 of iodine (Figure 2) [11, 12]. Twenty-six acetabular sockets (Trilogy, Zimmer, Warsaw, USA; Converge, Zimmer, Warsaw, USA; Tritanium, Stryker, Mahwah, USA), 4 acetabular reinforcement cages (KT-plate, Kyocera, Osaka, Japan; Contour, Smith & Nephew, Memphis, USA), and 26 femoral stems (Allo-classic, Zimmer, Warsaw, USA; CLS, Zimmer, Warsaw, USA; Mayo conservative hip, Zimmer, Warsaw, USA; S-ROM-A, DePuy-Synthes Warsaw, USA) were iodine-supported and implanted.

Bottom Line: No abnormalities of thyroid gland function were detected.Excellent bone ingrowth and ongrowth were found around prostheses.No cytotoxicity or adverse effects were detected.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8641, Japan.

ABSTRACT
We developed a new povidone iodine coating technology for titanium hip implants and performed a clinical trial to assess its usefulness in suppressing postoperative infection. Results indicate that iodine-supported titanium has favorable antibacterial activity, biocompatibility, and no cytotoxicity. Thirty joints in 28 patients were treated using iodine-supported implants. Fourteen joints were revision total hip arthroplasty (THA) after periprosthetic infection, 13 were primary THA for immunosuppressive conditions or pyogenic arthritis, and 3 were conversions from hemiarthroplasty to THA for immunosuppressive conditions. Two examinations were conducted sequentially until final follow-up: white blood cell (WBC) and C-reactive protein (CRP) were measured pre- and postoperatively and thyroid hormone levels in the blood were examined. The mean follow-up period was 33 months (14-78). There were no signs of infection in any patient at the last follow-up. WBC and CRP levels returned to normal within several weeks. No abnormalities of thyroid gland function were detected. Loosening of the implants did not occur in any patient. Excellent bone ingrowth and ongrowth were found around prostheses. No cytotoxicity or adverse effects were detected. These results suggest that iodine-supported THA implants can be highly effective in preventing and treating postoperative infections.

No MeSH data available.


Related in: MedlinePlus