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Frequency-Dependent Modulation of Regional Synchrony in the Human Brain by Eyes Open and Eyes Closed Resting-States.

Song X, Zhou S, Zhang Y, Liu Y, Zhu H, Gao JH - PLoS ONE (2015)

Bottom Line: Compared with the EC state, ReHo decreased with EO in a wide frequency band of 0.01-0.25 Hz in the bilateral thalamus, sensorimotor network, and superior temporal gyrus, while ReHo increased significantly in the band of 0-0.01 Hz in the primary visual cortex, and in a higher frequency band of 0.02-0.1 Hz in the higher order visual areas.Our results suggested that different frequency bands of ReHo showed different sensitivity to the modulation of EO-EC states.The better spatial consistency between the frequency and overall ReHo maps indicated that the brain might adopt a stricter frequency-dependent configuration with EO than with EC.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China.

ABSTRACT
The eyes-open (EO) and eyes-closed (EC) states have differential effects on BOLD-fMRI signal dynamics, affecting both the BOLD oscillation frequency of a single voxel and the regional homogeneity (ReHo) of several neighboring voxels. To explore how the two resting-states modulate the local synchrony through different frequency bands, we decomposed the time series of each voxel into several components that fell into distinct frequency bands. The ReHo in each of the bands was calculated and compared between the EO and EC conditions. The cross-voxel correlations between the mean frequency and the overall ReHo of each voxel's original BOLD series in different brain areas were also calculated and compared between the two states. Compared with the EC state, ReHo decreased with EO in a wide frequency band of 0.01-0.25 Hz in the bilateral thalamus, sensorimotor network, and superior temporal gyrus, while ReHo increased significantly in the band of 0-0.01 Hz in the primary visual cortex, and in a higher frequency band of 0.02-0.1 Hz in the higher order visual areas. The cross-voxel correlations between the frequency and overall ReHo were negative in all the brain areas but varied from region to region. These correlations were stronger with EO in the visual network and the default mode network. Our results suggested that different frequency bands of ReHo showed different sensitivity to the modulation of EO-EC states. The better spatial consistency between the frequency and overall ReHo maps indicated that the brain might adopt a stricter frequency-dependent configuration with EO than with EC.

No MeSH data available.


Related in: MedlinePlus

Paired t-tests of ReHo in different frequency bands.Results of the paired t-tests (P<0.01, Alphasim corrected) of the ReHo maps in the five IMFs between EO and EC conditions.
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pone.0141507.g003: Paired t-tests of ReHo in different frequency bands.Results of the paired t-tests (P<0.01, Alphasim corrected) of the ReHo maps in the five IMFs between EO and EC conditions.

Mentions: Fig 3 shows the results of paired t-tests (EO vs. EC, AlphaSim corrected, voxel-level p < 0.01, cluster size > 68 voxels, overall false positive P < 0.01) of the ReHo in the five frequency bands (IMFs). Consistent with the results of the ROI analysis, the voxel-wise paired t-tests showed significant decreased ReHo in the first four IMFs in the THA, SMA, sensorimotor cortex, and STG. The V1 showed significant increased ReHo in IMF5, while the hVIN showed significant increased ReHo in IMF2 and IMF3.


Frequency-Dependent Modulation of Regional Synchrony in the Human Brain by Eyes Open and Eyes Closed Resting-States.

Song X, Zhou S, Zhang Y, Liu Y, Zhu H, Gao JH - PLoS ONE (2015)

Paired t-tests of ReHo in different frequency bands.Results of the paired t-tests (P<0.01, Alphasim corrected) of the ReHo maps in the five IMFs between EO and EC conditions.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4636261&req=5

pone.0141507.g003: Paired t-tests of ReHo in different frequency bands.Results of the paired t-tests (P<0.01, Alphasim corrected) of the ReHo maps in the five IMFs between EO and EC conditions.
Mentions: Fig 3 shows the results of paired t-tests (EO vs. EC, AlphaSim corrected, voxel-level p < 0.01, cluster size > 68 voxels, overall false positive P < 0.01) of the ReHo in the five frequency bands (IMFs). Consistent with the results of the ROI analysis, the voxel-wise paired t-tests showed significant decreased ReHo in the first four IMFs in the THA, SMA, sensorimotor cortex, and STG. The V1 showed significant increased ReHo in IMF5, while the hVIN showed significant increased ReHo in IMF2 and IMF3.

Bottom Line: Compared with the EC state, ReHo decreased with EO in a wide frequency band of 0.01-0.25 Hz in the bilateral thalamus, sensorimotor network, and superior temporal gyrus, while ReHo increased significantly in the band of 0-0.01 Hz in the primary visual cortex, and in a higher frequency band of 0.02-0.1 Hz in the higher order visual areas.Our results suggested that different frequency bands of ReHo showed different sensitivity to the modulation of EO-EC states.The better spatial consistency between the frequency and overall ReHo maps indicated that the brain might adopt a stricter frequency-dependent configuration with EO than with EC.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China.

ABSTRACT
The eyes-open (EO) and eyes-closed (EC) states have differential effects on BOLD-fMRI signal dynamics, affecting both the BOLD oscillation frequency of a single voxel and the regional homogeneity (ReHo) of several neighboring voxels. To explore how the two resting-states modulate the local synchrony through different frequency bands, we decomposed the time series of each voxel into several components that fell into distinct frequency bands. The ReHo in each of the bands was calculated and compared between the EO and EC conditions. The cross-voxel correlations between the mean frequency and the overall ReHo of each voxel's original BOLD series in different brain areas were also calculated and compared between the two states. Compared with the EC state, ReHo decreased with EO in a wide frequency band of 0.01-0.25 Hz in the bilateral thalamus, sensorimotor network, and superior temporal gyrus, while ReHo increased significantly in the band of 0-0.01 Hz in the primary visual cortex, and in a higher frequency band of 0.02-0.1 Hz in the higher order visual areas. The cross-voxel correlations between the frequency and overall ReHo were negative in all the brain areas but varied from region to region. These correlations were stronger with EO in the visual network and the default mode network. Our results suggested that different frequency bands of ReHo showed different sensitivity to the modulation of EO-EC states. The better spatial consistency between the frequency and overall ReHo maps indicated that the brain might adopt a stricter frequency-dependent configuration with EO than with EC.

No MeSH data available.


Related in: MedlinePlus