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Frequency-Dependent Modulation of Regional Synchrony in the Human Brain by Eyes Open and Eyes Closed Resting-States.

Song X, Zhou S, Zhang Y, Liu Y, Zhu H, Gao JH - PLoS ONE (2015)

Bottom Line: Compared with the EC state, ReHo decreased with EO in a wide frequency band of 0.01-0.25 Hz in the bilateral thalamus, sensorimotor network, and superior temporal gyrus, while ReHo increased significantly in the band of 0-0.01 Hz in the primary visual cortex, and in a higher frequency band of 0.02-0.1 Hz in the higher order visual areas.Our results suggested that different frequency bands of ReHo showed different sensitivity to the modulation of EO-EC states.The better spatial consistency between the frequency and overall ReHo maps indicated that the brain might adopt a stricter frequency-dependent configuration with EO than with EC.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China.

ABSTRACT
The eyes-open (EO) and eyes-closed (EC) states have differential effects on BOLD-fMRI signal dynamics, affecting both the BOLD oscillation frequency of a single voxel and the regional homogeneity (ReHo) of several neighboring voxels. To explore how the two resting-states modulate the local synchrony through different frequency bands, we decomposed the time series of each voxel into several components that fell into distinct frequency bands. The ReHo in each of the bands was calculated and compared between the EO and EC conditions. The cross-voxel correlations between the mean frequency and the overall ReHo of each voxel's original BOLD series in different brain areas were also calculated and compared between the two states. Compared with the EC state, ReHo decreased with EO in a wide frequency band of 0.01-0.25 Hz in the bilateral thalamus, sensorimotor network, and superior temporal gyrus, while ReHo increased significantly in the band of 0-0.01 Hz in the primary visual cortex, and in a higher frequency band of 0.02-0.1 Hz in the higher order visual areas. The cross-voxel correlations between the frequency and overall ReHo were negative in all the brain areas but varied from region to region. These correlations were stronger with EO in the visual network and the default mode network. Our results suggested that different frequency bands of ReHo showed different sensitivity to the modulation of EO-EC states. The better spatial consistency between the frequency and overall ReHo maps indicated that the brain might adopt a stricter frequency-dependent configuration with EO than with EC.

No MeSH data available.


Related in: MedlinePlus

Brain areas with significant changes of frequency and overall ReHo.Results of the paired t-tests (P<0.01, Alphasim corrected) of Frequency (upper panel) and the overall ReHo (lower panel) between EO and EC conditions. The areas selected as ROIs are marked and labeled: a. Thalamus, b. Supplementary motor area (SMA), c. Sensorimotor cortex, d. Superior temporal gyrus (STG), e. Primary visual area (V1), f. High-order visual network (hVIN), g. Inferior frontal gyrus (IFG).
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pone.0141507.g001: Brain areas with significant changes of frequency and overall ReHo.Results of the paired t-tests (P<0.01, Alphasim corrected) of Frequency (upper panel) and the overall ReHo (lower panel) between EO and EC conditions. The areas selected as ROIs are marked and labeled: a. Thalamus, b. Supplementary motor area (SMA), c. Sensorimotor cortex, d. Superior temporal gyrus (STG), e. Primary visual area (V1), f. High-order visual network (hVIN), g. Inferior frontal gyrus (IFG).

Mentions: Fig 1 and Supporting Information S1 Table show the results of paired t-tests (EO vs. EC, AlphaSim corrected, voxel-level p < 0.01, cluster size > 68 voxels, overall false positive P < 0.01) of the frequency and the overall ReHo between EO and EC conditions. The results showed that, compared with the EC state, during the EO state, the bilateral thalamus (mainly the ventral lateral nucleus), supplementary motor area (SMA), sensorimotor cortex, and superior temporal gyrus (STG) showed significantly higher frequency but lower overall ReHo. The primary visual cortex (V1), higher order visual network (hVIN, consists of bilateral middle occipital gyrus and superior parietal gyrus), and bilateral inferior frontal gyrus (IFG, also includes part of the medial prefrontal cortex and orbital frontal cortex) showed significantly lower frequency with no significant changes of overall ReHo.


Frequency-Dependent Modulation of Regional Synchrony in the Human Brain by Eyes Open and Eyes Closed Resting-States.

Song X, Zhou S, Zhang Y, Liu Y, Zhu H, Gao JH - PLoS ONE (2015)

Brain areas with significant changes of frequency and overall ReHo.Results of the paired t-tests (P<0.01, Alphasim corrected) of Frequency (upper panel) and the overall ReHo (lower panel) between EO and EC conditions. The areas selected as ROIs are marked and labeled: a. Thalamus, b. Supplementary motor area (SMA), c. Sensorimotor cortex, d. Superior temporal gyrus (STG), e. Primary visual area (V1), f. High-order visual network (hVIN), g. Inferior frontal gyrus (IFG).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4636261&req=5

pone.0141507.g001: Brain areas with significant changes of frequency and overall ReHo.Results of the paired t-tests (P<0.01, Alphasim corrected) of Frequency (upper panel) and the overall ReHo (lower panel) between EO and EC conditions. The areas selected as ROIs are marked and labeled: a. Thalamus, b. Supplementary motor area (SMA), c. Sensorimotor cortex, d. Superior temporal gyrus (STG), e. Primary visual area (V1), f. High-order visual network (hVIN), g. Inferior frontal gyrus (IFG).
Mentions: Fig 1 and Supporting Information S1 Table show the results of paired t-tests (EO vs. EC, AlphaSim corrected, voxel-level p < 0.01, cluster size > 68 voxels, overall false positive P < 0.01) of the frequency and the overall ReHo between EO and EC conditions. The results showed that, compared with the EC state, during the EO state, the bilateral thalamus (mainly the ventral lateral nucleus), supplementary motor area (SMA), sensorimotor cortex, and superior temporal gyrus (STG) showed significantly higher frequency but lower overall ReHo. The primary visual cortex (V1), higher order visual network (hVIN, consists of bilateral middle occipital gyrus and superior parietal gyrus), and bilateral inferior frontal gyrus (IFG, also includes part of the medial prefrontal cortex and orbital frontal cortex) showed significantly lower frequency with no significant changes of overall ReHo.

Bottom Line: Compared with the EC state, ReHo decreased with EO in a wide frequency band of 0.01-0.25 Hz in the bilateral thalamus, sensorimotor network, and superior temporal gyrus, while ReHo increased significantly in the band of 0-0.01 Hz in the primary visual cortex, and in a higher frequency band of 0.02-0.1 Hz in the higher order visual areas.Our results suggested that different frequency bands of ReHo showed different sensitivity to the modulation of EO-EC states.The better spatial consistency between the frequency and overall ReHo maps indicated that the brain might adopt a stricter frequency-dependent configuration with EO than with EC.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China.

ABSTRACT
The eyes-open (EO) and eyes-closed (EC) states have differential effects on BOLD-fMRI signal dynamics, affecting both the BOLD oscillation frequency of a single voxel and the regional homogeneity (ReHo) of several neighboring voxels. To explore how the two resting-states modulate the local synchrony through different frequency bands, we decomposed the time series of each voxel into several components that fell into distinct frequency bands. The ReHo in each of the bands was calculated and compared between the EO and EC conditions. The cross-voxel correlations between the mean frequency and the overall ReHo of each voxel's original BOLD series in different brain areas were also calculated and compared between the two states. Compared with the EC state, ReHo decreased with EO in a wide frequency band of 0.01-0.25 Hz in the bilateral thalamus, sensorimotor network, and superior temporal gyrus, while ReHo increased significantly in the band of 0-0.01 Hz in the primary visual cortex, and in a higher frequency band of 0.02-0.1 Hz in the higher order visual areas. The cross-voxel correlations between the frequency and overall ReHo were negative in all the brain areas but varied from region to region. These correlations were stronger with EO in the visual network and the default mode network. Our results suggested that different frequency bands of ReHo showed different sensitivity to the modulation of EO-EC states. The better spatial consistency between the frequency and overall ReHo maps indicated that the brain might adopt a stricter frequency-dependent configuration with EO than with EC.

No MeSH data available.


Related in: MedlinePlus