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A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent "Heterosynaptic" LTD in the Dentate Gyrus In Vivo.

Jedlicka P, Benuskova L, Abraham WC - PLoS Comput. Biol. (2015)

Bottom Line: It remains uncertain, however, which particular activity rules are utilized by hippocampal neurons to induce LTP and LTD in behaving animals.Here we show in a biophysically realistic compartmental granule cell model that this pattern of results can be accounted for by a voltage-based spike-timing-dependent plasticity (STDP) rule combined with a relatively fast Bienenstock-Cooper-Munro (BCM)-like homeostatic metaplasticity rule, all on a background of ongoing spontaneous activity in the input fibers.Our results suggest that, at least for dentate granule cells, the interplay of STDP-BCM plasticity rules and ongoing pre- and postsynaptic background activity determines not only the degree of input-specific LTP elicited by various plasticity-inducing protocols, but also the degree of associated LTD in neighboring non-tetanized inputs, as generated by the ongoing constitutive activity at these synapses.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt, Germany.

ABSTRACT
Long-term potentiation (LTP) and long-term depression (LTD) are widely accepted to be synaptic mechanisms involved in learning and memory. It remains uncertain, however, which particular activity rules are utilized by hippocampal neurons to induce LTP and LTD in behaving animals. Recent experiments in the dentate gyrus of freely moving rats revealed an unexpected pattern of LTP and LTD from high-frequency perforant path stimulation. While 400 Hz theta-burst stimulation (400-TBS) and 400 Hz delta-burst stimulation (400-DBS) elicited substantial LTP of the tetanized medial path input and, concurrently, LTD of the non-tetanized lateral path input, 100 Hz theta-burst stimulation (100-TBS, a normally efficient LTP protocol for in vitro preparations) produced only weak LTP and concurrent LTD. Here we show in a biophysically realistic compartmental granule cell model that this pattern of results can be accounted for by a voltage-based spike-timing-dependent plasticity (STDP) rule combined with a relatively fast Bienenstock-Cooper-Munro (BCM)-like homeostatic metaplasticity rule, all on a background of ongoing spontaneous activity in the input fibers. Our results suggest that, at least for dentate granule cells, the interplay of STDP-BCM plasticity rules and ongoing pre- and postsynaptic background activity determines not only the degree of input-specific LTP elicited by various plasticity-inducing protocols, but also the degree of associated LTD in neighboring non-tetanized inputs, as generated by the ongoing constitutive activity at these synapses.

No MeSH data available.


Related in: MedlinePlus

Summary of effects of stimulation pattern on LTP and concurrent LTD in compartmental model simulations and experiments.400-DBS and 400-TBS produced greater LTP and concurrent LTD than 100-TBS; (A) in silico for the optimal values of parameters (average results from 3 runs); (B) in vivo (Bowden et al. 2012, [25]).
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pcbi.1004588.g003: Summary of effects of stimulation pattern on LTP and concurrent LTD in compartmental model simulations and experiments.400-DBS and 400-TBS produced greater LTP and concurrent LTD than 100-TBS; (A) in silico for the optimal values of parameters (average results from 3 runs); (B) in vivo (Bowden et al. 2012, [25]).

Mentions: Fig 3 summarizes the plasticity results (60% medial path tetanization) using the compartmental model, and compares them with the experimental data obtained by Bowden et al. [25], using the parameter set described above. It is important to consider, however, whether the qualitative or quantitative match with the experimental data is dependent on these specific parameters, or whether the STDP-BCM model has more generality. Accordingly we systematically varied the level of noise, τd, τp, the initial ratio of Ap / Ad and the dendritic threshold voltage for detecting the postsynaptic event for STDP pairing. The results are given as averages from 10 runs (± S.D.). To speed up these simulations, we reduced number of segments to 9, i.e. 1 for soma, 2 for the granule cell layer, 2 for the inner molecular layer, 2 for the middle molecular layer and 2 for outer molecular layer parts of the dendrites.


A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent "Heterosynaptic" LTD in the Dentate Gyrus In Vivo.

Jedlicka P, Benuskova L, Abraham WC - PLoS Comput. Biol. (2015)

Summary of effects of stimulation pattern on LTP and concurrent LTD in compartmental model simulations and experiments.400-DBS and 400-TBS produced greater LTP and concurrent LTD than 100-TBS; (A) in silico for the optimal values of parameters (average results from 3 runs); (B) in vivo (Bowden et al. 2012, [25]).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4636250&req=5

pcbi.1004588.g003: Summary of effects of stimulation pattern on LTP and concurrent LTD in compartmental model simulations and experiments.400-DBS and 400-TBS produced greater LTP and concurrent LTD than 100-TBS; (A) in silico for the optimal values of parameters (average results from 3 runs); (B) in vivo (Bowden et al. 2012, [25]).
Mentions: Fig 3 summarizes the plasticity results (60% medial path tetanization) using the compartmental model, and compares them with the experimental data obtained by Bowden et al. [25], using the parameter set described above. It is important to consider, however, whether the qualitative or quantitative match with the experimental data is dependent on these specific parameters, or whether the STDP-BCM model has more generality. Accordingly we systematically varied the level of noise, τd, τp, the initial ratio of Ap / Ad and the dendritic threshold voltage for detecting the postsynaptic event for STDP pairing. The results are given as averages from 10 runs (± S.D.). To speed up these simulations, we reduced number of segments to 9, i.e. 1 for soma, 2 for the granule cell layer, 2 for the inner molecular layer, 2 for the middle molecular layer and 2 for outer molecular layer parts of the dendrites.

Bottom Line: It remains uncertain, however, which particular activity rules are utilized by hippocampal neurons to induce LTP and LTD in behaving animals.Here we show in a biophysically realistic compartmental granule cell model that this pattern of results can be accounted for by a voltage-based spike-timing-dependent plasticity (STDP) rule combined with a relatively fast Bienenstock-Cooper-Munro (BCM)-like homeostatic metaplasticity rule, all on a background of ongoing spontaneous activity in the input fibers.Our results suggest that, at least for dentate granule cells, the interplay of STDP-BCM plasticity rules and ongoing pre- and postsynaptic background activity determines not only the degree of input-specific LTP elicited by various plasticity-inducing protocols, but also the degree of associated LTD in neighboring non-tetanized inputs, as generated by the ongoing constitutive activity at these synapses.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt, Germany.

ABSTRACT
Long-term potentiation (LTP) and long-term depression (LTD) are widely accepted to be synaptic mechanisms involved in learning and memory. It remains uncertain, however, which particular activity rules are utilized by hippocampal neurons to induce LTP and LTD in behaving animals. Recent experiments in the dentate gyrus of freely moving rats revealed an unexpected pattern of LTP and LTD from high-frequency perforant path stimulation. While 400 Hz theta-burst stimulation (400-TBS) and 400 Hz delta-burst stimulation (400-DBS) elicited substantial LTP of the tetanized medial path input and, concurrently, LTD of the non-tetanized lateral path input, 100 Hz theta-burst stimulation (100-TBS, a normally efficient LTP protocol for in vitro preparations) produced only weak LTP and concurrent LTD. Here we show in a biophysically realistic compartmental granule cell model that this pattern of results can be accounted for by a voltage-based spike-timing-dependent plasticity (STDP) rule combined with a relatively fast Bienenstock-Cooper-Munro (BCM)-like homeostatic metaplasticity rule, all on a background of ongoing spontaneous activity in the input fibers. Our results suggest that, at least for dentate granule cells, the interplay of STDP-BCM plasticity rules and ongoing pre- and postsynaptic background activity determines not only the degree of input-specific LTP elicited by various plasticity-inducing protocols, but also the degree of associated LTD in neighboring non-tetanized inputs, as generated by the ongoing constitutive activity at these synapses.

No MeSH data available.


Related in: MedlinePlus