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Tripled Readout Slices in Multi Time-Point pCASL Using Multiband Look-Locker EPI.

Zhang K, Yun SD, Shah NJ - PLoS ONE (2015)

Bottom Line: The aim of this study is to employ a multiband excitation technique to triple the number of readout slices in multi time-point pCASL.The multiband technique, along with 2-fold in-plane parallel imaging, was incorporated into the Look-Locker EPI for the multi time-point sampling of blood kinetic behaviour following the pCASL labelling scheme.The performance evaluation of the multiband and the single-band techniques were performed on four healthy subjects using a 32-channel head RF coil at 3T.

View Article: PubMed Central - PubMed

Affiliation: Institute of Neuroscience and Medicine- 4, Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany.

ABSTRACT
Multi time-point pseudo-continuous arterial spin labelling (pCASL) with a Look-Locker EPI readout can sample the signal curve of blood kinetics at multiple time points after the labelling pulse. However, due to signal relaxation of labelled blood, the number of readout slices is limited. The aim of this study is to employ a multiband excitation technique to triple the number of readout slices in multi time-point pCASL. The multiband technique, along with 2-fold in-plane parallel imaging, was incorporated into the Look-Locker EPI for the multi time-point sampling of blood kinetic behaviour following the pCASL labelling scheme. The performance evaluation of the multiband and the single-band techniques were performed on four healthy subjects using a 32-channel head RF coil at 3T. Quantitative perfusion maps were analysed using a combination of labelling with and without flow suppression gradients. The perfusion maps provided by the multiband accelerated multi time-point pCASL were in good agreement with the conventional single-band technique. Multiband acceleration caused SNR loss but offered quantitative perfusion maps in 6.23 min with 18 slices compared with 6 slices within the same time period for the single-band method. As conclusion, the multiband technique can successfully triple the number of readout slices while achieving comparable perfusion data in the same measurement time as the conventional single-band readout.

No MeSH data available.


Related in: MedlinePlus

(a) Quantitative CBF ranging from 0 to 140 mL/100g/min when using the SB and MB techniques. Increased brain coverage in sagittal orientation (arrows) was observed with the MB method. (b) Corresponding histograms of the CBF from SB (top) and MB (bottom).
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pone.0141108.g004: (a) Quantitative CBF ranging from 0 to 140 mL/100g/min when using the SB and MB techniques. Increased brain coverage in sagittal orientation (arrows) was observed with the MB method. (b) Corresponding histograms of the CBF from SB (top) and MB (bottom).

Mentions: After fitting to the kinetic model for the whole-brain tissue signal, quantitative perfusion maps derived from one subject are shown in the 3 orthogonal views in Fig 4. Both the SB and MB-CBF fit well within the colour scale ranging from 0 to 140 mL/100g/min (Fig 4A). The enhancement resulting from the MB technique with regard to brain coverage is especially evident in the sagittal orientation. The histograms of the whole-brain CBF from the same subject (Fig 4B) show similar Gaussian-like distributions with a mean value of 56.9 mL/100g/min for SB-CBF and 54.2 mL/100g/min for MB-CBF. Furthermore, a smoother histogram of the MB-CBF can be observed when compared to the one acquired using the SB method.


Tripled Readout Slices in Multi Time-Point pCASL Using Multiband Look-Locker EPI.

Zhang K, Yun SD, Shah NJ - PLoS ONE (2015)

(a) Quantitative CBF ranging from 0 to 140 mL/100g/min when using the SB and MB techniques. Increased brain coverage in sagittal orientation (arrows) was observed with the MB method. (b) Corresponding histograms of the CBF from SB (top) and MB (bottom).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4636240&req=5

pone.0141108.g004: (a) Quantitative CBF ranging from 0 to 140 mL/100g/min when using the SB and MB techniques. Increased brain coverage in sagittal orientation (arrows) was observed with the MB method. (b) Corresponding histograms of the CBF from SB (top) and MB (bottom).
Mentions: After fitting to the kinetic model for the whole-brain tissue signal, quantitative perfusion maps derived from one subject are shown in the 3 orthogonal views in Fig 4. Both the SB and MB-CBF fit well within the colour scale ranging from 0 to 140 mL/100g/min (Fig 4A). The enhancement resulting from the MB technique with regard to brain coverage is especially evident in the sagittal orientation. The histograms of the whole-brain CBF from the same subject (Fig 4B) show similar Gaussian-like distributions with a mean value of 56.9 mL/100g/min for SB-CBF and 54.2 mL/100g/min for MB-CBF. Furthermore, a smoother histogram of the MB-CBF can be observed when compared to the one acquired using the SB method.

Bottom Line: The aim of this study is to employ a multiband excitation technique to triple the number of readout slices in multi time-point pCASL.The multiband technique, along with 2-fold in-plane parallel imaging, was incorporated into the Look-Locker EPI for the multi time-point sampling of blood kinetic behaviour following the pCASL labelling scheme.The performance evaluation of the multiband and the single-band techniques were performed on four healthy subjects using a 32-channel head RF coil at 3T.

View Article: PubMed Central - PubMed

Affiliation: Institute of Neuroscience and Medicine- 4, Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany.

ABSTRACT
Multi time-point pseudo-continuous arterial spin labelling (pCASL) with a Look-Locker EPI readout can sample the signal curve of blood kinetics at multiple time points after the labelling pulse. However, due to signal relaxation of labelled blood, the number of readout slices is limited. The aim of this study is to employ a multiband excitation technique to triple the number of readout slices in multi time-point pCASL. The multiband technique, along with 2-fold in-plane parallel imaging, was incorporated into the Look-Locker EPI for the multi time-point sampling of blood kinetic behaviour following the pCASL labelling scheme. The performance evaluation of the multiband and the single-band techniques were performed on four healthy subjects using a 32-channel head RF coil at 3T. Quantitative perfusion maps were analysed using a combination of labelling with and without flow suppression gradients. The perfusion maps provided by the multiband accelerated multi time-point pCASL were in good agreement with the conventional single-band technique. Multiband acceleration caused SNR loss but offered quantitative perfusion maps in 6.23 min with 18 slices compared with 6 slices within the same time period for the single-band method. As conclusion, the multiband technique can successfully triple the number of readout slices while achieving comparable perfusion data in the same measurement time as the conventional single-band readout.

No MeSH data available.


Related in: MedlinePlus