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Elevated Vibration Perception Thresholds in CIDP Patients Indicate More Severe Neuropathy and Lower Treatment Response Rates.

Abraham A, Albulaihe H, Alabdali M, Qrimli M, Breiner A, Barnett C, Katzberg HD, Lovblom LE, Perkins BA, Bril V - PLoS ONE (2015)

Bottom Line: Vibration perception threshold (VPT) examination using a neurothesiometer provides objective, sensitive and specific information, and has been utilized mainly in patients with diabetic polyneropathy.VPT examination is a simple tool, which is a reliable and sensitive measure not only for diabetic neuropathy, but also for CIDP.Moreover, in CIDP, elevated VPT values are also associated with lower treatment response rates.

View Article: PubMed Central - PubMed

Affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.

ABSTRACT

Introduction: Vibration perception threshold (VPT) examination using a neurothesiometer provides objective, sensitive and specific information, and has been utilized mainly in patients with diabetic polyneropathy.

Objectives: Explore the utility of VPT examination in CIDP patients.

Methods: CIDP subjects attending the Neuromuscular clinic between 01/2013 and 12/2014 were evaluated. Demographic data, clinical history, physical examination, VPT values, and electrophysiologic data from their charts were extracted.

Results: 70 charts were reviewed. 55 CIDP patients had elevated VPT, associated with higher frequency of abnormal sensory testing for various modalities (92.7% vs. 46.7%, p<0.0001), lower sensory and motor amplitudes and reduced conduction velocities on nerve conduction studies, and lower treatment response rates (54% vs. 93%, p = 0.01).

Conclusion: VPT examination is a simple tool, which is a reliable and sensitive measure not only for diabetic neuropathy, but also for CIDP. Moreover, in CIDP, elevated VPT values are also associated with lower treatment response rates.

No MeSH data available.


Related in: MedlinePlus

VPT Toe.AUC for Sural Amp = 0.83 and Sural CV = 0.84. AUC for Peroneal Amp = 0.75 and Peroneal CV = 0.72. AUC for Tibial Amp = 0.87 and Tibial CV = 0.75.
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pone.0139689.g002: VPT Toe.AUC for Sural Amp = 0.83 and Sural CV = 0.84. AUC for Peroneal Amp = 0.75 and Peroneal CV = 0.72. AUC for Tibial Amp = 0.87 and Tibial CV = 0.75.

Mentions: VPT receiver operating characteristic ROC area under curves were generally high, especially for sural nerve amplitude (0.83), conduction velocity (0.84), and tibial nerve motor amplitude (0.87) (Figs 1 and 2).


Elevated Vibration Perception Thresholds in CIDP Patients Indicate More Severe Neuropathy and Lower Treatment Response Rates.

Abraham A, Albulaihe H, Alabdali M, Qrimli M, Breiner A, Barnett C, Katzberg HD, Lovblom LE, Perkins BA, Bril V - PLoS ONE (2015)

VPT Toe.AUC for Sural Amp = 0.83 and Sural CV = 0.84. AUC for Peroneal Amp = 0.75 and Peroneal CV = 0.72. AUC for Tibial Amp = 0.87 and Tibial CV = 0.75.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4636179&req=5

pone.0139689.g002: VPT Toe.AUC for Sural Amp = 0.83 and Sural CV = 0.84. AUC for Peroneal Amp = 0.75 and Peroneal CV = 0.72. AUC for Tibial Amp = 0.87 and Tibial CV = 0.75.
Mentions: VPT receiver operating characteristic ROC area under curves were generally high, especially for sural nerve amplitude (0.83), conduction velocity (0.84), and tibial nerve motor amplitude (0.87) (Figs 1 and 2).

Bottom Line: Vibration perception threshold (VPT) examination using a neurothesiometer provides objective, sensitive and specific information, and has been utilized mainly in patients with diabetic polyneropathy.VPT examination is a simple tool, which is a reliable and sensitive measure not only for diabetic neuropathy, but also for CIDP.Moreover, in CIDP, elevated VPT values are also associated with lower treatment response rates.

View Article: PubMed Central - PubMed

Affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.

ABSTRACT

Introduction: Vibration perception threshold (VPT) examination using a neurothesiometer provides objective, sensitive and specific information, and has been utilized mainly in patients with diabetic polyneropathy.

Objectives: Explore the utility of VPT examination in CIDP patients.

Methods: CIDP subjects attending the Neuromuscular clinic between 01/2013 and 12/2014 were evaluated. Demographic data, clinical history, physical examination, VPT values, and electrophysiologic data from their charts were extracted.

Results: 70 charts were reviewed. 55 CIDP patients had elevated VPT, associated with higher frequency of abnormal sensory testing for various modalities (92.7% vs. 46.7%, p<0.0001), lower sensory and motor amplitudes and reduced conduction velocities on nerve conduction studies, and lower treatment response rates (54% vs. 93%, p = 0.01).

Conclusion: VPT examination is a simple tool, which is a reliable and sensitive measure not only for diabetic neuropathy, but also for CIDP. Moreover, in CIDP, elevated VPT values are also associated with lower treatment response rates.

No MeSH data available.


Related in: MedlinePlus