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Resting-State fMRI Functional Connectivity Is Associated with Sleepiness, Imagery, and Discontinuity of Mind.

Stoffers D, Diaz BA, Chen G, den Braber A, van 't Ent D, Boomsma DI, Mansvelder HD, de Geus E, Van Someren EJ, Linkenkaer-Hansen K - PLoS ONE (2015)

Bottom Line: We identified 11 positive associations between brain-network functional connectivity and ARSQ dimensions. 'Sleepiness' exhibited significant associations with functional connectivity within Visual, Sensorimotor and Default Mode networks.Similar associations were observed for 'Visual Thought' and 'Discontinuity of Mind', which may relate to variation in imagery and thought control mediated by arousal fluctuations.Our findings show that self-reports of thoughts and feelings experienced during a rs-fMRI scan help understand the functional significance of variations in functional connectivity, which should be of special relevance to clinical studies.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, The Netherlands.

ABSTRACT
Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to investigate the functional architecture of the healthy human brain and how it is affected by learning, lifelong development, brain disorders or pharmacological intervention. Non-sensory experiences are prevalent during rest and must arise from ongoing brain activity, yet little is known about this relationship. Here, we used two runs of rs-fMRI both immediately followed by the Amsterdam Resting-State Questionnaire (ARSQ) to investigate the relationship between functional connectivity within ten large-scale functional brain networks and ten dimensions of thoughts and feelings experienced during the scan in 106 healthy participants. We identified 11 positive associations between brain-network functional connectivity and ARSQ dimensions. 'Sleepiness' exhibited significant associations with functional connectivity within Visual, Sensorimotor and Default Mode networks. Similar associations were observed for 'Visual Thought' and 'Discontinuity of Mind', which may relate to variation in imagery and thought control mediated by arousal fluctuations. Our findings show that self-reports of thoughts and feelings experienced during a rs-fMRI scan help understand the functional significance of variations in functional connectivity, which should be of special relevance to clinical studies.

No MeSH data available.


Related in: MedlinePlus

Sleepiness promotes widespread increases in functional connectivity.A total of eleven combinations of ICNs and ARSQ dimensions showed significant associations between functional connectivity and ARSQ score at a cluster-wise Bonferroni-corrected significance threshold of PFWE = .00025. Orthogonal slices through the peak voxel are shown on the left of each panel; ICNs are defined by the ICA spatial maps thresholded at Z = 2.3 and displayed in green, clusters of voxels showing significant associations (2.62 < t < 6) in a gradient from red to yellow, overlaid on a standard brain template in radiological convention (left = right). Number of significant voxels, maximum t-statistic and peak voxel coordinates are displayed at the top right, scatter plots showing the mean functional connectivity value in significant clusters (y-axis) plotted against the relevant ARSQ measure are shown in the bottom right of each panel.
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pone.0142014.g004: Sleepiness promotes widespread increases in functional connectivity.A total of eleven combinations of ICNs and ARSQ dimensions showed significant associations between functional connectivity and ARSQ score at a cluster-wise Bonferroni-corrected significance threshold of PFWE = .00025. Orthogonal slices through the peak voxel are shown on the left of each panel; ICNs are defined by the ICA spatial maps thresholded at Z = 2.3 and displayed in green, clusters of voxels showing significant associations (2.62 < t < 6) in a gradient from red to yellow, overlaid on a standard brain template in radiological convention (left = right). Number of significant voxels, maximum t-statistic and peak voxel coordinates are displayed at the top right, scatter plots showing the mean functional connectivity value in significant clusters (y-axis) plotted against the relevant ARSQ measure are shown in the bottom right of each panel.

Mentions: A total of four dimensions of resting-state cognition and five different ICNs showed positive associations at a Bonferroni corrected cluster-wise significance threshold of PFWE = .00025 (Fig 4). Subjective ratings of sleepiness exhibited the most pronounced associations with higher scores characterized by increased functional connectivity in widespread regions within the Occipital Visual, Lateral Visual, Sensorimotor and Default Mode networks (Fig 4A–4D). These findings are in line with recent EEG-fMRI work showing increased BOLD functional connectivity in occipital brain regions with EEG-defined decrements in arousal [4].


Resting-State fMRI Functional Connectivity Is Associated with Sleepiness, Imagery, and Discontinuity of Mind.

Stoffers D, Diaz BA, Chen G, den Braber A, van 't Ent D, Boomsma DI, Mansvelder HD, de Geus E, Van Someren EJ, Linkenkaer-Hansen K - PLoS ONE (2015)

Sleepiness promotes widespread increases in functional connectivity.A total of eleven combinations of ICNs and ARSQ dimensions showed significant associations between functional connectivity and ARSQ score at a cluster-wise Bonferroni-corrected significance threshold of PFWE = .00025. Orthogonal slices through the peak voxel are shown on the left of each panel; ICNs are defined by the ICA spatial maps thresholded at Z = 2.3 and displayed in green, clusters of voxels showing significant associations (2.62 < t < 6) in a gradient from red to yellow, overlaid on a standard brain template in radiological convention (left = right). Number of significant voxels, maximum t-statistic and peak voxel coordinates are displayed at the top right, scatter plots showing the mean functional connectivity value in significant clusters (y-axis) plotted against the relevant ARSQ measure are shown in the bottom right of each panel.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4634926&req=5

pone.0142014.g004: Sleepiness promotes widespread increases in functional connectivity.A total of eleven combinations of ICNs and ARSQ dimensions showed significant associations between functional connectivity and ARSQ score at a cluster-wise Bonferroni-corrected significance threshold of PFWE = .00025. Orthogonal slices through the peak voxel are shown on the left of each panel; ICNs are defined by the ICA spatial maps thresholded at Z = 2.3 and displayed in green, clusters of voxels showing significant associations (2.62 < t < 6) in a gradient from red to yellow, overlaid on a standard brain template in radiological convention (left = right). Number of significant voxels, maximum t-statistic and peak voxel coordinates are displayed at the top right, scatter plots showing the mean functional connectivity value in significant clusters (y-axis) plotted against the relevant ARSQ measure are shown in the bottom right of each panel.
Mentions: A total of four dimensions of resting-state cognition and five different ICNs showed positive associations at a Bonferroni corrected cluster-wise significance threshold of PFWE = .00025 (Fig 4). Subjective ratings of sleepiness exhibited the most pronounced associations with higher scores characterized by increased functional connectivity in widespread regions within the Occipital Visual, Lateral Visual, Sensorimotor and Default Mode networks (Fig 4A–4D). These findings are in line with recent EEG-fMRI work showing increased BOLD functional connectivity in occipital brain regions with EEG-defined decrements in arousal [4].

Bottom Line: We identified 11 positive associations between brain-network functional connectivity and ARSQ dimensions. 'Sleepiness' exhibited significant associations with functional connectivity within Visual, Sensorimotor and Default Mode networks.Similar associations were observed for 'Visual Thought' and 'Discontinuity of Mind', which may relate to variation in imagery and thought control mediated by arousal fluctuations.Our findings show that self-reports of thoughts and feelings experienced during a rs-fMRI scan help understand the functional significance of variations in functional connectivity, which should be of special relevance to clinical studies.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, The Netherlands.

ABSTRACT
Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to investigate the functional architecture of the healthy human brain and how it is affected by learning, lifelong development, brain disorders or pharmacological intervention. Non-sensory experiences are prevalent during rest and must arise from ongoing brain activity, yet little is known about this relationship. Here, we used two runs of rs-fMRI both immediately followed by the Amsterdam Resting-State Questionnaire (ARSQ) to investigate the relationship between functional connectivity within ten large-scale functional brain networks and ten dimensions of thoughts and feelings experienced during the scan in 106 healthy participants. We identified 11 positive associations between brain-network functional connectivity and ARSQ dimensions. 'Sleepiness' exhibited significant associations with functional connectivity within Visual, Sensorimotor and Default Mode networks. Similar associations were observed for 'Visual Thought' and 'Discontinuity of Mind', which may relate to variation in imagery and thought control mediated by arousal fluctuations. Our findings show that self-reports of thoughts and feelings experienced during a rs-fMRI scan help understand the functional significance of variations in functional connectivity, which should be of special relevance to clinical studies.

No MeSH data available.


Related in: MedlinePlus