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Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia.

Zhang C, Zhong JF, Stucky A, Chen XL, Press MF, Zhang X - Clin Epigenetics (2015)

Bottom Line: However, in recent years, significant advances have been made in the elucidation of the ALL-associated processes.Thus, we understand that histone acetylation is involved in the permanent changes of gene expression controlling ALL developmental outcomes.In this article, we will focus on histone acetylation associated with ALL, their implications as biomarkers for prognostic, and their preclinical and clinical applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037 People's Republic of China.

ABSTRACT
Acute lymphoblastic leukemia (ALL) has been generally considered a genetic disease (disorder) with an aggressive tumor entity of highly proliferative malignant lymphoid cells. However, in recent years, significant advances have been made in the elucidation of the ALL-associated processes. Thus, we understand that histone acetylation is involved in the permanent changes of gene expression controlling ALL developmental outcomes. In this article, we will focus on histone acetylation associated with ALL, their implications as biomarkers for prognostic, and their preclinical and clinical applications.

No MeSH data available.


Related in: MedlinePlus

Histone acetylation alters chromatin structure. Acetylation removes the positive charge on the histones with histone acetyltransferases, which is referred to as euchromatin. As a consequence, the condensed chromatin is transformed into a more relaxed structure that is associated with greater levels of gene transcription. However, this relaxation can be reversed by histone deacetylase, which is referred to as heterochromatin. Acetylation has been closely associated with increases in transcriptional activation while deacetylation has been linked with transcriptional deactivation
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Fig1: Histone acetylation alters chromatin structure. Acetylation removes the positive charge on the histones with histone acetyltransferases, which is referred to as euchromatin. As a consequence, the condensed chromatin is transformed into a more relaxed structure that is associated with greater levels of gene transcription. However, this relaxation can be reversed by histone deacetylase, which is referred to as heterochromatin. Acetylation has been closely associated with increases in transcriptional activation while deacetylation has been linked with transcriptional deactivation

Mentions: Histone acetylation has been closely associated with increases in transcriptional activation while deacetylation has been linked with transcriptional deactivation and is known as gene silencing, and histone acetylation also causes changes in transcription activity (Fig. 1) [8–15]. Histone proteins modified by acetyl groups add negative charges to positive lysines, thus, reducing the interaction between DNA and histones [16–19]. This opens up the usually tightly packed nucleosome and allows transcription machinery to come into contact with the DNA template, leading to gene transcription. The acetyl group is removed by one of the HDAC enzymes during deacetylation, allowing histones to interact with DNA more tightly to form compacted nucleosome assemblies, which can effectively silence gene transcription.Fig. 1


Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia.

Zhang C, Zhong JF, Stucky A, Chen XL, Press MF, Zhang X - Clin Epigenetics (2015)

Histone acetylation alters chromatin structure. Acetylation removes the positive charge on the histones with histone acetyltransferases, which is referred to as euchromatin. As a consequence, the condensed chromatin is transformed into a more relaxed structure that is associated with greater levels of gene transcription. However, this relaxation can be reversed by histone deacetylase, which is referred to as heterochromatin. Acetylation has been closely associated with increases in transcriptional activation while deacetylation has been linked with transcriptional deactivation
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4634719&req=5

Fig1: Histone acetylation alters chromatin structure. Acetylation removes the positive charge on the histones with histone acetyltransferases, which is referred to as euchromatin. As a consequence, the condensed chromatin is transformed into a more relaxed structure that is associated with greater levels of gene transcription. However, this relaxation can be reversed by histone deacetylase, which is referred to as heterochromatin. Acetylation has been closely associated with increases in transcriptional activation while deacetylation has been linked with transcriptional deactivation
Mentions: Histone acetylation has been closely associated with increases in transcriptional activation while deacetylation has been linked with transcriptional deactivation and is known as gene silencing, and histone acetylation also causes changes in transcription activity (Fig. 1) [8–15]. Histone proteins modified by acetyl groups add negative charges to positive lysines, thus, reducing the interaction between DNA and histones [16–19]. This opens up the usually tightly packed nucleosome and allows transcription machinery to come into contact with the DNA template, leading to gene transcription. The acetyl group is removed by one of the HDAC enzymes during deacetylation, allowing histones to interact with DNA more tightly to form compacted nucleosome assemblies, which can effectively silence gene transcription.Fig. 1

Bottom Line: However, in recent years, significant advances have been made in the elucidation of the ALL-associated processes.Thus, we understand that histone acetylation is involved in the permanent changes of gene expression controlling ALL developmental outcomes.In this article, we will focus on histone acetylation associated with ALL, their implications as biomarkers for prognostic, and their preclinical and clinical applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037 People's Republic of China.

ABSTRACT
Acute lymphoblastic leukemia (ALL) has been generally considered a genetic disease (disorder) with an aggressive tumor entity of highly proliferative malignant lymphoid cells. However, in recent years, significant advances have been made in the elucidation of the ALL-associated processes. Thus, we understand that histone acetylation is involved in the permanent changes of gene expression controlling ALL developmental outcomes. In this article, we will focus on histone acetylation associated with ALL, their implications as biomarkers for prognostic, and their preclinical and clinical applications.

No MeSH data available.


Related in: MedlinePlus