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Antidiabetic effect of honey feeding in noise induced hyperglycemic rat: involvement of oxidative stress.

Arabmoazzen S, Sarkaki A, Saki G, Mirshekar MA - Iran J Basic Med Sci (2015)

Bottom Line: Meanwhile, honey treatment significantly ameliorated the increased malondialdehyde (MDA) content and reduced the activity of superoxide dismutase (SOD) in brain.Histology of langerhans islets in hyperglycemic group showed a lower number and granularity of beta cells; honey treatment produced beneficial change in this respect.Oral administration of honey in experimental model of diabetes showed a significant hypoglycemic effect and led to appropriate changes in serum lipid profiles.

View Article: PubMed Central - PubMed

Affiliation: Deptartment of Biology, Basic Sciences Faculty, Sciences and Researches, Azad University, Tehran, Iran.

ABSTRACT

Objectives: In this study the effect of oral administration of honey on serum glucose, lipids, stress oxidative markers, and morphology of langerhans islets in noise induced hyperglycemic rats was investigated.

Materials and methods: Male Wistar rats were divided into control, hyperglycemic, honey treated control, and honey treated hyperglycemic groups. For induction of hyperglycemia, noise stress was used. Serum glucose, triglyceride (TG), total cholesterol, low density lipoprotein (LDL), and high density lipoprotein (HDL)-cholesterol levels were determined before the study and at 4(th) and 8(th) weeks after the study. Markers of oxidative stress in brain were also measured. Morphology of langerhans islets in four groups was evaluated using Gomori staining method.

Results: Treatment of noise induced hyperglycemic rats with honey produced a hypoglycemic effect and appropriate changes regarding serum lipids in treated diabetic group at 4(th) and 8(th) weeks as compared to the control group. Meanwhile, honey treatment significantly ameliorated the increased malondialdehyde (MDA) content and reduced the activity of superoxide dismutase (SOD) in brain. Histology of langerhans islets in hyperglycemic group showed a lower number and granularity of beta cells; honey treatment produced beneficial change in this respect.

Conclusion: Oral administration of honey in experimental model of diabetes showed a significant hypoglycemic effect and led to appropriate changes in serum lipid profiles.

No MeSH data available.


Related in: MedlinePlus

Body weight in weeks 0 (baseline), 4, and 8, (means±SEM) ** P<0.01 (as compared to week 0 in the same group); ## P<0.01 (as compared to noise group in the same week)
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Figure 1: Body weight in weeks 0 (baseline), 4, and 8, (means±SEM) ** P<0.01 (as compared to week 0 in the same group); ## P<0.01 (as compared to noise group in the same week)

Mentions: One rat was excluded at final weeks of the study due to severe weight loss and immobility. Meanwhile, 82% of rats were made diabetic following noise induction and had a serum glucose level higher than 250 mg/dl. The data for drinks intake was significantly increased in the vehicle treated noise induced rats (140±15 ml/rat/day) compared to control group (42±8 ml/rat/day) (P<0.001). This data in honey treated group was (100±7 ml/rat/day). After eight weeks, the weight of the vehicle treated noise induced rats was significantly decreased as compared to control rats (175±16) (P<0.01); honey treatment caused a less significant decrease in diabetic rats as compared to noise induced diabetic rats (226±11.9), (P<0.01), (Figure 1). In addition, noise induced rats had also an elevated serum glucose level over those of control rats (401±25.9) P<0.001); treatment of these rats with honey caused a significant decrease in the serum glucose (208±34.6) (P<0.01), relative to noise induced group. Meanwhile, honey treatment of control rats did not produce any significant change regarding serum glucose level (112.8±16.4) (Figure 2).


Antidiabetic effect of honey feeding in noise induced hyperglycemic rat: involvement of oxidative stress.

Arabmoazzen S, Sarkaki A, Saki G, Mirshekar MA - Iran J Basic Med Sci (2015)

Body weight in weeks 0 (baseline), 4, and 8, (means±SEM) ** P<0.01 (as compared to week 0 in the same group); ## P<0.01 (as compared to noise group in the same week)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4633456&req=5

Figure 1: Body weight in weeks 0 (baseline), 4, and 8, (means±SEM) ** P<0.01 (as compared to week 0 in the same group); ## P<0.01 (as compared to noise group in the same week)
Mentions: One rat was excluded at final weeks of the study due to severe weight loss and immobility. Meanwhile, 82% of rats were made diabetic following noise induction and had a serum glucose level higher than 250 mg/dl. The data for drinks intake was significantly increased in the vehicle treated noise induced rats (140±15 ml/rat/day) compared to control group (42±8 ml/rat/day) (P<0.001). This data in honey treated group was (100±7 ml/rat/day). After eight weeks, the weight of the vehicle treated noise induced rats was significantly decreased as compared to control rats (175±16) (P<0.01); honey treatment caused a less significant decrease in diabetic rats as compared to noise induced diabetic rats (226±11.9), (P<0.01), (Figure 1). In addition, noise induced rats had also an elevated serum glucose level over those of control rats (401±25.9) P<0.001); treatment of these rats with honey caused a significant decrease in the serum glucose (208±34.6) (P<0.01), relative to noise induced group. Meanwhile, honey treatment of control rats did not produce any significant change regarding serum glucose level (112.8±16.4) (Figure 2).

Bottom Line: Meanwhile, honey treatment significantly ameliorated the increased malondialdehyde (MDA) content and reduced the activity of superoxide dismutase (SOD) in brain.Histology of langerhans islets in hyperglycemic group showed a lower number and granularity of beta cells; honey treatment produced beneficial change in this respect.Oral administration of honey in experimental model of diabetes showed a significant hypoglycemic effect and led to appropriate changes in serum lipid profiles.

View Article: PubMed Central - PubMed

Affiliation: Deptartment of Biology, Basic Sciences Faculty, Sciences and Researches, Azad University, Tehran, Iran.

ABSTRACT

Objectives: In this study the effect of oral administration of honey on serum glucose, lipids, stress oxidative markers, and morphology of langerhans islets in noise induced hyperglycemic rats was investigated.

Materials and methods: Male Wistar rats were divided into control, hyperglycemic, honey treated control, and honey treated hyperglycemic groups. For induction of hyperglycemia, noise stress was used. Serum glucose, triglyceride (TG), total cholesterol, low density lipoprotein (LDL), and high density lipoprotein (HDL)-cholesterol levels were determined before the study and at 4(th) and 8(th) weeks after the study. Markers of oxidative stress in brain were also measured. Morphology of langerhans islets in four groups was evaluated using Gomori staining method.

Results: Treatment of noise induced hyperglycemic rats with honey produced a hypoglycemic effect and appropriate changes regarding serum lipids in treated diabetic group at 4(th) and 8(th) weeks as compared to the control group. Meanwhile, honey treatment significantly ameliorated the increased malondialdehyde (MDA) content and reduced the activity of superoxide dismutase (SOD) in brain. Histology of langerhans islets in hyperglycemic group showed a lower number and granularity of beta cells; honey treatment produced beneficial change in this respect.

Conclusion: Oral administration of honey in experimental model of diabetes showed a significant hypoglycemic effect and led to appropriate changes in serum lipid profiles.

No MeSH data available.


Related in: MedlinePlus