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Characterization of Soft Tissue Tumors by Diffusion-Weighted Imaging.

Pekcevik Y, Kahya MO, Kaya A - Iran J Radiol (2015)

Bottom Line: We grouped soft tissue tumors as benign cystic, benign solid or mixed, malignant cystic and malignant solid or mixed tumors and compared mean ADC values between these groups.Benign cystic tumors had significantly higher ADC values than benign solid or mixed tumors and malignant solid or mixed tumors (p values were < 0.001 and 0.003, respectively).Malignant solid or mixed tumors had lower ADC values than benign solid or mixed tumors (P = 0.02).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Tepecik Training and Research Hospital, Izmir, Turkey.

ABSTRACT

Background: Diffusion-weighted imaging (DWI) is a noninvasive method for investigation of tumor histological content. It has been applied for some musculoskeletal tumors and reported to be useful.

Objectives: The aim of the present study was to prospectively evaluate the apparent diffusion coefficient (ADC) values of benign and malignant soft tissue tumors and to determine if ADC can help differentiate these tumors.

Patients and methods: DWI was performed on 25 histologically proven soft tissue masses. It was obtained with a single-shot echo-planar imaging technique using a 1.5T magnetic resonance (MR) machine. The mean ADC values were calculated. We grouped soft tissue tumors as benign cystic, benign solid or mixed, malignant cystic and malignant solid or mixed tumors and compared mean ADC values between these groups.

Results: There was only one patient with a malignant cystic tumor and was not included in the statistical analysis. The median ADC values of benign and malignant tumors were 2.31 ± 1.29 and 0.90 ± 0.70 (median ± interquartile range), respectively. The mean ADC values were different between benign and malignant tumors (P = 0.031). Benign cystic tumors had significantly higher ADC values than benign solid or mixed tumors and malignant solid or mixed tumors (p values were < 0.001 and 0.003, respectively). Malignant solid or mixed tumors had lower ADC values than benign solid or mixed tumors (P = 0.02).

Conclusion: Our preliminary results have shown that although there is some overlap between benign and malignant tumors, adding DWI, MR imaging to routine soft tissue tumor protocols may improve diagnostic accuracy.

No MeSH data available.


Related in: MedlinePlus

Magnetic resonance imaging of seventeen-year-old male with neurofibroma in the thigh. A, Axial T1-weighted. B, Fat-suppressed proton density.C, T1-weighted fat suppression postcontrast images. D, ADC maps. Mean ADC value was 1.92 × 10 -3 mm2/sec.
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fig20745: Magnetic resonance imaging of seventeen-year-old male with neurofibroma in the thigh. A, Axial T1-weighted. B, Fat-suppressed proton density.C, T1-weighted fat suppression postcontrast images. D, ADC maps. Mean ADC value was 1.92 × 10 -3 mm2/sec.

Mentions: Nine patients had benign cystic tumors: three had a ganglion cyst, three had complex synovial cyst, two had epidermal cyst and one had complicated Baker’s cyst. Ten patients had benign solid or mixed tumors, three had hemangioma, two had schwannoma, while chronic hematoma, neurofibroma (Figure 1), fibromatosis, giant cell tumor of tendon sheath and pigmented villonodular synovitis affected one patient each. There was only one patient in the malignant cystic tumor group (pleomorphic liposarcoma). Five patients had malignant solid or mixed tumors, two had soft tissue metastasis from lung adenocarcinoma (Figure 2), one had embryonal rhabdomyosarcoma, one had synovial sarcoma, and one had undifferentiated soft tissue sarcoma. Lesions were located in the thighs (5), knees, ankles (4), buttock, phalanx (2), groin, shoulder, upper arm, forearm and calf (1).


Characterization of Soft Tissue Tumors by Diffusion-Weighted Imaging.

Pekcevik Y, Kahya MO, Kaya A - Iran J Radiol (2015)

Magnetic resonance imaging of seventeen-year-old male with neurofibroma in the thigh. A, Axial T1-weighted. B, Fat-suppressed proton density.C, T1-weighted fat suppression postcontrast images. D, ADC maps. Mean ADC value was 1.92 × 10 -3 mm2/sec.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4632135&req=5

fig20745: Magnetic resonance imaging of seventeen-year-old male with neurofibroma in the thigh. A, Axial T1-weighted. B, Fat-suppressed proton density.C, T1-weighted fat suppression postcontrast images. D, ADC maps. Mean ADC value was 1.92 × 10 -3 mm2/sec.
Mentions: Nine patients had benign cystic tumors: three had a ganglion cyst, three had complex synovial cyst, two had epidermal cyst and one had complicated Baker’s cyst. Ten patients had benign solid or mixed tumors, three had hemangioma, two had schwannoma, while chronic hematoma, neurofibroma (Figure 1), fibromatosis, giant cell tumor of tendon sheath and pigmented villonodular synovitis affected one patient each. There was only one patient in the malignant cystic tumor group (pleomorphic liposarcoma). Five patients had malignant solid or mixed tumors, two had soft tissue metastasis from lung adenocarcinoma (Figure 2), one had embryonal rhabdomyosarcoma, one had synovial sarcoma, and one had undifferentiated soft tissue sarcoma. Lesions were located in the thighs (5), knees, ankles (4), buttock, phalanx (2), groin, shoulder, upper arm, forearm and calf (1).

Bottom Line: We grouped soft tissue tumors as benign cystic, benign solid or mixed, malignant cystic and malignant solid or mixed tumors and compared mean ADC values between these groups.Benign cystic tumors had significantly higher ADC values than benign solid or mixed tumors and malignant solid or mixed tumors (p values were < 0.001 and 0.003, respectively).Malignant solid or mixed tumors had lower ADC values than benign solid or mixed tumors (P = 0.02).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Tepecik Training and Research Hospital, Izmir, Turkey.

ABSTRACT

Background: Diffusion-weighted imaging (DWI) is a noninvasive method for investigation of tumor histological content. It has been applied for some musculoskeletal tumors and reported to be useful.

Objectives: The aim of the present study was to prospectively evaluate the apparent diffusion coefficient (ADC) values of benign and malignant soft tissue tumors and to determine if ADC can help differentiate these tumors.

Patients and methods: DWI was performed on 25 histologically proven soft tissue masses. It was obtained with a single-shot echo-planar imaging technique using a 1.5T magnetic resonance (MR) machine. The mean ADC values were calculated. We grouped soft tissue tumors as benign cystic, benign solid or mixed, malignant cystic and malignant solid or mixed tumors and compared mean ADC values between these groups.

Results: There was only one patient with a malignant cystic tumor and was not included in the statistical analysis. The median ADC values of benign and malignant tumors were 2.31 ± 1.29 and 0.90 ± 0.70 (median ± interquartile range), respectively. The mean ADC values were different between benign and malignant tumors (P = 0.031). Benign cystic tumors had significantly higher ADC values than benign solid or mixed tumors and malignant solid or mixed tumors (p values were < 0.001 and 0.003, respectively). Malignant solid or mixed tumors had lower ADC values than benign solid or mixed tumors (P = 0.02).

Conclusion: Our preliminary results have shown that although there is some overlap between benign and malignant tumors, adding DWI, MR imaging to routine soft tissue tumor protocols may improve diagnostic accuracy.

No MeSH data available.


Related in: MedlinePlus