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Bacterial Spectrum and Antibiotic Resistance Patterns of Ocular Infection: Differences between External and Intraocular Diseases.

Wang N, Yang Q, Tan Y, Lin L, Huang Q, Wu K - J Ophthalmol (2015)

Bottom Line: The organisms cultured from the ocular surface (cornea, conjunctiva) accounted for the majority of the isolates (82.77%, n = 610), followed by the intraocular (aqueous humor, vitreous fluid), which accounted for 17.23% (n = 127).The top three species for the intraocular infections were S. epidermidis (14.96%), S. hominis (8.66%), and B. subtilis (7.87%).A high percentage of bacterial organisms were found to be primarily susceptible to neomycin for external infection and levofloxacin for intraocular infection.

View Article: PubMed Central - PubMed

Affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou 510060, China.

ABSTRACT
This study aimed to compare the differences of microbial spectrum and antibiotic resistance patterns between external and intraocular bacterial infections in an eye hospital in South China. A total of 737 bacteria isolates from suspected ocular infections were included in this retrospective study covering the period 2010-2013. The organisms cultured from the ocular surface (cornea, conjunctiva) accounted for the majority of the isolates (82.77%, n = 610), followed by the intraocular (aqueous humor, vitreous fluid), which accounted for 17.23% (n = 127). The top three species accounting for the external ocular infections were S. epidermidis (35.25%), P. aeruginosa (8.03%), and S. simulans (4.43%). The top three species for the intraocular infections were S. epidermidis (14.96%), S. hominis (8.66%), and B. subtilis (7.87%). The bacteria from the external ocular surface were more sensitive to neomycin, while those from the intraocular specimens were more sensitive to levofloxacin (P < 0.01). Multidrug resistance was found in 89 bacteria (12.08%), including isolates from both external (13.28%) and intraocular samples (6.30%). The results of this study indicate that the bacteria spectrum of external and intraocular infections is variable in the setting. A high percentage of bacterial organisms were found to be primarily susceptible to neomycin for external infection and levofloxacin for intraocular infection.

No MeSH data available.


Related in: MedlinePlus

The drug-resistance of bacteria isolates from different ocular tissues to eight antibiotics. (a) Comparison of external ocular (black) and intraocular (gray) bacteria isolates; (b) comparison of cornea (black) and conjunctiva (gray) isolates. ∗P < 0.05, ∗∗P < 0.01.
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fig1: The drug-resistance of bacteria isolates from different ocular tissues to eight antibiotics. (a) Comparison of external ocular (black) and intraocular (gray) bacteria isolates; (b) comparison of cornea (black) and conjunctiva (gray) isolates. ∗P < 0.05, ∗∗P < 0.01.

Mentions: A comparison of the antibiotic resistance of external and intraocular bacteria to ceftazidime, cefuroxime, cefazolin, levofloxacin, ofloxacin, neomycin, tobramycin, and chloramphenicol was shown in Figure 1(a). Generally, among five antibiotics that are present in eye drop products in China, the bacteria found in the external ocular were more sensitive to neomycin, while bacteria from intraocular isolates were significantly more sensitive to levofloxacin than to neomycin (P < 0.01). Meanwhile, for the cephalosporins, the intraocular isolates showed a high sensitivity to ceftazidime. There were significant differences in resistance to levofloxacin and chloramphenicol between external and intraocular isolates (P < 0.05). The antibiotic resistance of S. epidermidis in both external and intraocular infections showed no significant differences compared to these eight antibiotics. The comparison of the antibiotic resistance of cornea and conjunctiva bacteria isolates to eight antibiotics was shown in Figure 1(b). On the whole, cornea bacteria isolates exhibited significantly higher resistance to cefazolin, cefuroxime, and chloramphenicol as compared to conjunctival isolates (P < 0.01).


Bacterial Spectrum and Antibiotic Resistance Patterns of Ocular Infection: Differences between External and Intraocular Diseases.

Wang N, Yang Q, Tan Y, Lin L, Huang Q, Wu K - J Ophthalmol (2015)

The drug-resistance of bacteria isolates from different ocular tissues to eight antibiotics. (a) Comparison of external ocular (black) and intraocular (gray) bacteria isolates; (b) comparison of cornea (black) and conjunctiva (gray) isolates. ∗P < 0.05, ∗∗P < 0.01.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4631901&req=5

fig1: The drug-resistance of bacteria isolates from different ocular tissues to eight antibiotics. (a) Comparison of external ocular (black) and intraocular (gray) bacteria isolates; (b) comparison of cornea (black) and conjunctiva (gray) isolates. ∗P < 0.05, ∗∗P < 0.01.
Mentions: A comparison of the antibiotic resistance of external and intraocular bacteria to ceftazidime, cefuroxime, cefazolin, levofloxacin, ofloxacin, neomycin, tobramycin, and chloramphenicol was shown in Figure 1(a). Generally, among five antibiotics that are present in eye drop products in China, the bacteria found in the external ocular were more sensitive to neomycin, while bacteria from intraocular isolates were significantly more sensitive to levofloxacin than to neomycin (P < 0.01). Meanwhile, for the cephalosporins, the intraocular isolates showed a high sensitivity to ceftazidime. There were significant differences in resistance to levofloxacin and chloramphenicol between external and intraocular isolates (P < 0.05). The antibiotic resistance of S. epidermidis in both external and intraocular infections showed no significant differences compared to these eight antibiotics. The comparison of the antibiotic resistance of cornea and conjunctiva bacteria isolates to eight antibiotics was shown in Figure 1(b). On the whole, cornea bacteria isolates exhibited significantly higher resistance to cefazolin, cefuroxime, and chloramphenicol as compared to conjunctival isolates (P < 0.01).

Bottom Line: The organisms cultured from the ocular surface (cornea, conjunctiva) accounted for the majority of the isolates (82.77%, n = 610), followed by the intraocular (aqueous humor, vitreous fluid), which accounted for 17.23% (n = 127).The top three species for the intraocular infections were S. epidermidis (14.96%), S. hominis (8.66%), and B. subtilis (7.87%).A high percentage of bacterial organisms were found to be primarily susceptible to neomycin for external infection and levofloxacin for intraocular infection.

View Article: PubMed Central - PubMed

Affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou 510060, China.

ABSTRACT
This study aimed to compare the differences of microbial spectrum and antibiotic resistance patterns between external and intraocular bacterial infections in an eye hospital in South China. A total of 737 bacteria isolates from suspected ocular infections were included in this retrospective study covering the period 2010-2013. The organisms cultured from the ocular surface (cornea, conjunctiva) accounted for the majority of the isolates (82.77%, n = 610), followed by the intraocular (aqueous humor, vitreous fluid), which accounted for 17.23% (n = 127). The top three species accounting for the external ocular infections were S. epidermidis (35.25%), P. aeruginosa (8.03%), and S. simulans (4.43%). The top three species for the intraocular infections were S. epidermidis (14.96%), S. hominis (8.66%), and B. subtilis (7.87%). The bacteria from the external ocular surface were more sensitive to neomycin, while those from the intraocular specimens were more sensitive to levofloxacin (P < 0.01). Multidrug resistance was found in 89 bacteria (12.08%), including isolates from both external (13.28%) and intraocular samples (6.30%). The results of this study indicate that the bacteria spectrum of external and intraocular infections is variable in the setting. A high percentage of bacterial organisms were found to be primarily susceptible to neomycin for external infection and levofloxacin for intraocular infection.

No MeSH data available.


Related in: MedlinePlus