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The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis.

Wang S, Song K, Srivastava R, Fathzadeh M, Li N, Mani A - J Diabetes Res (2015)

Bottom Line: Dominant, recessive, homozygote, and heterozygote comparison models were utilized. 24 studies incorporating 52,785 subjects were included in this meta-analysis.No association was found between minor (T) allele and plasma TC, LDL-c, or HDL-c levels in subjects with type 2 diabetes or metabolic syndrome (MetS) and no association was found between minor (T) allele and plasma TG levels in nondiabetic subjects.Our meta-analysis indicated the association between TCF7L2 rs7903146 polymorphism and low plasma triglyceride (TG) level in subjects with type 2 diabetes.

View Article: PubMed Central - PubMed

Affiliation: The Geriatric Cardiology Department, Chinese PLA General Hospital, Beijing 100853, China ; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.

ABSTRACT

Background: The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive.

Methods: We carried out a meta-analysis that aimed to investigate the association of the rs7903146 variant with plasma lipid levels using electronic database and published studies. Data was extracted by a standard algorithm. Dominant, recessive, homozygote, and heterozygote comparison models were utilized.

Results: 24 studies incorporating 52,785 subjects were included in this meta-analysis. Overall, the minor allele (T) was associated with lower risk for hypertriglyceridemia in subjects with type 2 diabetes (dominant model: SMD = -0.04, 95% CI (-0.08, 0.00), P = 0.048, P heterogeneity = 0.47; recessive model: SMD = -0.10, 95% CI (-0.18, -0.02), P = 0.01, P heterogeneity = 0.56). No association was found between minor (T) allele and plasma TC, LDL-c, or HDL-c levels in subjects with type 2 diabetes or metabolic syndrome (MetS) and no association was found between minor (T) allele and plasma TG levels in nondiabetic subjects.

Conclusions: Our meta-analysis indicated the association between TCF7L2 rs7903146 polymorphism and low plasma triglyceride (TG) level in subjects with type 2 diabetes. No association was found between rs7903146 variant and plasma lipids in nondiabetic subjects.

No MeSH data available.


Related in: MedlinePlus

Flowchart outlining the process of search criteria and study selection.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Flowchart outlining the process of search criteria and study selection.

Mentions: A total of 490 articles were identified searching PubMed, Embase, and Cochrane Library databases and from a manual approach (search of previous studies cited in the reviews and the reference lists of identified articles); 461 articles were excluded because they were not conducted in human or did not meet the goals of this meta-analysis. Full text assessment of the 29 potentially relevant articles resulted in 24 eligible studies that met the inclusion criteria for the meta-analysis (Figure 1). The most common reasons for the exclusions were as follows: data were limited to isolated pedigrees [33, 34], were incomplete [35], or involved subjects younger than 18 years of age [36] and/or belonged to subjects that were studied in 2 or more published studies [37] (Figure 1).


The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis.

Wang S, Song K, Srivastava R, Fathzadeh M, Li N, Mani A - J Diabetes Res (2015)

Flowchart outlining the process of search criteria and study selection.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4631899&req=5

fig1: Flowchart outlining the process of search criteria and study selection.
Mentions: A total of 490 articles were identified searching PubMed, Embase, and Cochrane Library databases and from a manual approach (search of previous studies cited in the reviews and the reference lists of identified articles); 461 articles were excluded because they were not conducted in human or did not meet the goals of this meta-analysis. Full text assessment of the 29 potentially relevant articles resulted in 24 eligible studies that met the inclusion criteria for the meta-analysis (Figure 1). The most common reasons for the exclusions were as follows: data were limited to isolated pedigrees [33, 34], were incomplete [35], or involved subjects younger than 18 years of age [36] and/or belonged to subjects that were studied in 2 or more published studies [37] (Figure 1).

Bottom Line: Dominant, recessive, homozygote, and heterozygote comparison models were utilized. 24 studies incorporating 52,785 subjects were included in this meta-analysis.No association was found between minor (T) allele and plasma TC, LDL-c, or HDL-c levels in subjects with type 2 diabetes or metabolic syndrome (MetS) and no association was found between minor (T) allele and plasma TG levels in nondiabetic subjects.Our meta-analysis indicated the association between TCF7L2 rs7903146 polymorphism and low plasma triglyceride (TG) level in subjects with type 2 diabetes.

View Article: PubMed Central - PubMed

Affiliation: The Geriatric Cardiology Department, Chinese PLA General Hospital, Beijing 100853, China ; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.

ABSTRACT

Background: The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive.

Methods: We carried out a meta-analysis that aimed to investigate the association of the rs7903146 variant with plasma lipid levels using electronic database and published studies. Data was extracted by a standard algorithm. Dominant, recessive, homozygote, and heterozygote comparison models were utilized.

Results: 24 studies incorporating 52,785 subjects were included in this meta-analysis. Overall, the minor allele (T) was associated with lower risk for hypertriglyceridemia in subjects with type 2 diabetes (dominant model: SMD = -0.04, 95% CI (-0.08, 0.00), P = 0.048, P heterogeneity = 0.47; recessive model: SMD = -0.10, 95% CI (-0.18, -0.02), P = 0.01, P heterogeneity = 0.56). No association was found between minor (T) allele and plasma TC, LDL-c, or HDL-c levels in subjects with type 2 diabetes or metabolic syndrome (MetS) and no association was found between minor (T) allele and plasma TG levels in nondiabetic subjects.

Conclusions: Our meta-analysis indicated the association between TCF7L2 rs7903146 polymorphism and low plasma triglyceride (TG) level in subjects with type 2 diabetes. No association was found between rs7903146 variant and plasma lipids in nondiabetic subjects.

No MeSH data available.


Related in: MedlinePlus