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Effectiveness of music therapy as an aid to neurorestoration of children with severe neurological disorders

View Article: PubMed Central

ABSTRACT

This study was a two-armed parallel group design aimed at testing real world effectiveness of a music therapy (MT) intervention for children with severe neurological disorders. The control group received only the standard neurorestoration program and the experimental group received an additional MT “Auditory Attention plus Communication protocol” just before the usual occupational and speech therapy. Multivariate Item Response Theory (MIRT) identified a neuropsychological status-latent variable manifested in all children and which exhibited highly significant changes only in the experimental group. Changes in brain plasticity also occurred in the experimental group, as evidenced using a Mismatch Event Related paradigm which revealed significant post intervention positive responses in the latency range between 308 and 400 ms in frontal regions. LORETA EEG source analysis identified prefrontal and midcingulate regions as differentially activated by the MT in the experimental group. Taken together, our results showing improved attention and communication as well as changes in brain plasticity in children with severe neurological impairments, confirm the importance of MT for the rehabilitation of patients across a wide range of dysfunctions.

No MeSH data available.


Sources localization of the music therapy specific mismatch responses. The one sided t-test of LORETA images plotted on the MNI brain template identifying significant activation in the midcingulate (bilateral) and prefrontal cortex.
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Figure 6: Sources localization of the music therapy specific mismatch responses. The one sided t-test of LORETA images plotted on the MNI brain template identifying significant activation in the midcingulate (bilateral) and prefrontal cortex.

Mentions: Source analysis of the MMR identified two specific regions (at the latency of 351 ms) that significantly increase activity when MT is given in addition to standard neurorestoration therapy (p = 0.041). These regions were the right prefrontal cortex and the bilateral medial cingulate cortex (Figure 6).


Effectiveness of music therapy as an aid to neurorestoration of children with severe neurological disorders
Sources localization of the music therapy specific mismatch responses. The one sided t-test of LORETA images plotted on the MNI brain template identifying significant activation in the midcingulate (bilateral) and prefrontal cortex.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4631829&req=5

Figure 6: Sources localization of the music therapy specific mismatch responses. The one sided t-test of LORETA images plotted on the MNI brain template identifying significant activation in the midcingulate (bilateral) and prefrontal cortex.
Mentions: Source analysis of the MMR identified two specific regions (at the latency of 351 ms) that significantly increase activity when MT is given in addition to standard neurorestoration therapy (p = 0.041). These regions were the right prefrontal cortex and the bilateral medial cingulate cortex (Figure 6).

View Article: PubMed Central

ABSTRACT

This study was a two-armed parallel group design aimed at testing real world effectiveness of a music therapy (MT) intervention for children with severe neurological disorders. The control group received only the standard neurorestoration program and the experimental group received an additional MT “Auditory Attention plus Communication protocol” just before the usual occupational and speech therapy. Multivariate Item Response Theory (MIRT) identified a neuropsychological status-latent variable manifested in all children and which exhibited highly significant changes only in the experimental group. Changes in brain plasticity also occurred in the experimental group, as evidenced using a Mismatch Event Related paradigm which revealed significant post intervention positive responses in the latency range between 308 and 400 ms in frontal regions. LORETA EEG source analysis identified prefrontal and midcingulate regions as differentially activated by the MT in the experimental group. Taken together, our results showing improved attention and communication as well as changes in brain plasticity in children with severe neurological impairments, confirm the importance of MT for the rehabilitation of patients across a wide range of dysfunctions.

No MeSH data available.