Limits...
Brain-derived neurotrophic factor serum levels in genetically isolated populations: gender-specific association with anxiety disorder subtypes but not with anxiety levels or Val66Met polymorphism.

Carlino D, Francavilla R, Baj G, Kulak K, d'Adamo P, Ulivi S, Cappellani S, Gasparini P, Tongiorgi E - PeerJ (2015)

Bottom Line: This study was aimed at testing the hypothesis that ADs may be associated with reduced neurotrophic activity, particularly of Brain-derived neurotrophic factor (BDNF), and determining possible effects of genetics on serum BDNF concentrations.Stratification of subjects highlighted a significant decrease in serum BDNF in females with GAD and males with PHSP.Our results show that BDNF is not a general biomarker of anxiety but serum BDNF levels correlate in a gender-specific manner with ADs subtypes.

View Article: PubMed Central - HTML - PubMed

Affiliation: Psychiatric Clinic, Department of Surgical and Medical Sciences, University of Trieste , Trieste , Italy.

ABSTRACT
Anxiety disorders (ADs) are disabling chronic disorders with exaggerated behavioral response to threats. This study was aimed at testing the hypothesis that ADs may be associated with reduced neurotrophic activity, particularly of Brain-derived neurotrophic factor (BDNF), and determining possible effects of genetics on serum BDNF concentrations. In 672 adult subjects from six isolated villages in North-Eastern Italy with high inbreeding, we determined serum BDNF levels and identified subjects with different ADs subtypes such as Social and Specific Phobias (PHSOC, PHSP), Generalized Anxiety Disorder (GAD), and Panic Disorder (PAD). Analysis of the population as a whole or individual village showed no significant correlation between serum BDNF levels and Val66Met polymorphism and no association with anxiety levels. Stratification of subjects highlighted a significant decrease in serum BDNF in females with GAD and males with PHSP. This study indicates low heritability and absence of any impact of the Val66Met polymorphism on circulating concentrations of BDNF. Our results show that BDNF is not a general biomarker of anxiety but serum BDNF levels correlate in a gender-specific manner with ADs subtypes.

No MeSH data available.


Related in: MedlinePlus

Analysis of BDNF levels gender differences in Generalized Anxiety Disorders and Specific Phobia.(A) Serum BDNF level in male and female groups affected by Generalized Anxiety Disorder; n, number of subjects [healthy donors, patients]; male [219, 28], female [201, 63]. Comparison using Mann–Whitney U Test 1-tail shows significant statistical difference in serum BDNF level between the two groups in female subjects (∗, p = 0.025). (B) Serum BDNF level in male and female groups affected by Specific Phobia; male [219, 15], female [201, 82]. Comparison Mann–Whitney U Test 1-tail shows significant statistical difference in serum BDNF level between the two groups in male subjects (∗, p = 0.018). Abbreviation: HD, Healthy Donors; GAD, Generalized Anxiety Disorders; PHSP, Specific Phobia.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4631459&req=5

fig-4: Analysis of BDNF levels gender differences in Generalized Anxiety Disorders and Specific Phobia.(A) Serum BDNF level in male and female groups affected by Generalized Anxiety Disorder; n, number of subjects [healthy donors, patients]; male [219, 28], female [201, 63]. Comparison using Mann–Whitney U Test 1-tail shows significant statistical difference in serum BDNF level between the two groups in female subjects (∗, p = 0.025). (B) Serum BDNF level in male and female groups affected by Specific Phobia; male [219, 15], female [201, 82]. Comparison Mann–Whitney U Test 1-tail shows significant statistical difference in serum BDNF level between the two groups in male subjects (∗, p = 0.018). Abbreviation: HD, Healthy Donors; GAD, Generalized Anxiety Disorders; PHSP, Specific Phobia.

Mentions: Finally, serum BDNF levels were compared separately in males and females from the healthy donor group versus each ADs category. Comparison showed a statistically significant reduction of serum BDNF level in GAD female subjects with respect to female HD (Fig. 4A; p = 0.025, Mann–Whitney U test 1 tail) but not in males. In contrast, in males affected by PHSP there was a significant reduction in serum BDNF levels in comparison to healthy donors, but not in females (Fig. 4B; male [219, 15] p = 0.018, female [201, 63]; Mann–Whitney U test 1 tail). No significant gender difference was found for patients with PAD and PHSOC.


Brain-derived neurotrophic factor serum levels in genetically isolated populations: gender-specific association with anxiety disorder subtypes but not with anxiety levels or Val66Met polymorphism.

Carlino D, Francavilla R, Baj G, Kulak K, d'Adamo P, Ulivi S, Cappellani S, Gasparini P, Tongiorgi E - PeerJ (2015)

Analysis of BDNF levels gender differences in Generalized Anxiety Disorders and Specific Phobia.(A) Serum BDNF level in male and female groups affected by Generalized Anxiety Disorder; n, number of subjects [healthy donors, patients]; male [219, 28], female [201, 63]. Comparison using Mann–Whitney U Test 1-tail shows significant statistical difference in serum BDNF level between the two groups in female subjects (∗, p = 0.025). (B) Serum BDNF level in male and female groups affected by Specific Phobia; male [219, 15], female [201, 82]. Comparison Mann–Whitney U Test 1-tail shows significant statistical difference in serum BDNF level between the two groups in male subjects (∗, p = 0.018). Abbreviation: HD, Healthy Donors; GAD, Generalized Anxiety Disorders; PHSP, Specific Phobia.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4631459&req=5

fig-4: Analysis of BDNF levels gender differences in Generalized Anxiety Disorders and Specific Phobia.(A) Serum BDNF level in male and female groups affected by Generalized Anxiety Disorder; n, number of subjects [healthy donors, patients]; male [219, 28], female [201, 63]. Comparison using Mann–Whitney U Test 1-tail shows significant statistical difference in serum BDNF level between the two groups in female subjects (∗, p = 0.025). (B) Serum BDNF level in male and female groups affected by Specific Phobia; male [219, 15], female [201, 82]. Comparison Mann–Whitney U Test 1-tail shows significant statistical difference in serum BDNF level between the two groups in male subjects (∗, p = 0.018). Abbreviation: HD, Healthy Donors; GAD, Generalized Anxiety Disorders; PHSP, Specific Phobia.
Mentions: Finally, serum BDNF levels were compared separately in males and females from the healthy donor group versus each ADs category. Comparison showed a statistically significant reduction of serum BDNF level in GAD female subjects with respect to female HD (Fig. 4A; p = 0.025, Mann–Whitney U test 1 tail) but not in males. In contrast, in males affected by PHSP there was a significant reduction in serum BDNF levels in comparison to healthy donors, but not in females (Fig. 4B; male [219, 15] p = 0.018, female [201, 63]; Mann–Whitney U test 1 tail). No significant gender difference was found for patients with PAD and PHSOC.

Bottom Line: This study was aimed at testing the hypothesis that ADs may be associated with reduced neurotrophic activity, particularly of Brain-derived neurotrophic factor (BDNF), and determining possible effects of genetics on serum BDNF concentrations.Stratification of subjects highlighted a significant decrease in serum BDNF in females with GAD and males with PHSP.Our results show that BDNF is not a general biomarker of anxiety but serum BDNF levels correlate in a gender-specific manner with ADs subtypes.

View Article: PubMed Central - HTML - PubMed

Affiliation: Psychiatric Clinic, Department of Surgical and Medical Sciences, University of Trieste , Trieste , Italy.

ABSTRACT
Anxiety disorders (ADs) are disabling chronic disorders with exaggerated behavioral response to threats. This study was aimed at testing the hypothesis that ADs may be associated with reduced neurotrophic activity, particularly of Brain-derived neurotrophic factor (BDNF), and determining possible effects of genetics on serum BDNF concentrations. In 672 adult subjects from six isolated villages in North-Eastern Italy with high inbreeding, we determined serum BDNF levels and identified subjects with different ADs subtypes such as Social and Specific Phobias (PHSOC, PHSP), Generalized Anxiety Disorder (GAD), and Panic Disorder (PAD). Analysis of the population as a whole or individual village showed no significant correlation between serum BDNF levels and Val66Met polymorphism and no association with anxiety levels. Stratification of subjects highlighted a significant decrease in serum BDNF in females with GAD and males with PHSP. This study indicates low heritability and absence of any impact of the Val66Met polymorphism on circulating concentrations of BDNF. Our results show that BDNF is not a general biomarker of anxiety but serum BDNF levels correlate in a gender-specific manner with ADs subtypes.

No MeSH data available.


Related in: MedlinePlus