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The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study.

Štillová K, Jurák P, Chládek J, Chrastina J, Halámek J, Bočková M, Goldemundová S, Říha I, Rektor I - PLoS ONE (2015)

Bottom Line: To study the involvement of the anterior nuclei of the thalamus (ANT) as compared to the involvement of the hippocampus in the processes of encoding and recognition during visual and verbal memory tasks.No significant ERPs were recorded during the verbal encoding task in the ANT.ANT is well positioned to serve as a subcortical gate for memory processing in cortical structures.

View Article: PubMed Central - PubMed

Affiliation: Central European Institute of Technology CEITEC, Brain and Mind Research Program, Brno, Czech Republic; Department of Neurology, St. Anne´s Teaching Hospital, Medical School of Masaryk University, Brno, Czech Republic.

ABSTRACT

Objective: To study the involvement of the anterior nuclei of the thalamus (ANT) as compared to the involvement of the hippocampus in the processes of encoding and recognition during visual and verbal memory tasks.

Methods: We studied intracerebral recordings in patients with pharmacoresistent epilepsy who underwent deep brain stimulation (DBS) of the ANT with depth electrodes implanted bilaterally in the ANT and compared the results with epilepsy surgery candidates with depth electrodes implanted bilaterally in the hippocampus. We recorded the event-related potentials (ERPs) elicited by the visual and verbal memory encoding and recognition tasks.

Results: P300-like potentials were recorded in the hippocampus by visual and verbal memory encoding and recognition tasks and in the ANT by the visual encoding and visual and verbal recognition tasks. No significant ERPs were recorded during the verbal encoding task in the ANT. In the visual and verbal recognition tasks, the P300-like potentials in the ANT preceded the P300-like potentials in the hippocampus.

Conclusions: The ANT is a structure in the memory pathway that processes memory information before the hippocampus. We suggest that the ANT has a specific role in memory processes, especially memory recognition, and that memory disturbance should be considered in patients with ANT-DBS and in patients with ANT lesions. ANT is well positioned to serve as a subcortical gate for memory processing in cortical structures.

No MeSH data available.


Related in: MedlinePlus

Visual recognition task in the ANT: N 115- P 150- N 200- P 250 and N700 complex (the mean from all thalamic contacts from all patients in bipolar montage during the recognition task).Arrows mark fast and slow ERP components N115, P150, N200, P250, and N700. The black curve indicates a new stimulus (new picture); red indicates a repeated stimulus during the recognition phase (old picture). On axis x is time (in s). The statistical significance to baseline is highlighted by black and red horizontal lines.
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pone.0140778.g003: Visual recognition task in the ANT: N 115- P 150- N 200- P 250 and N700 complex (the mean from all thalamic contacts from all patients in bipolar montage during the recognition task).Arrows mark fast and slow ERP components N115, P150, N200, P250, and N700. The black curve indicates a new stimulus (new picture); red indicates a repeated stimulus during the recognition phase (old picture). On axis x is time (in s). The statistical significance to baseline is highlighted by black and red horizontal lines.

Mentions: ERPs elicited by the visual encoding task and the visual and verbal recognition tasks were recorded in the ANT. In the visual encoding and recognition tasks an N 115- P 150- N 200- P 250 and N700 complex was detected (Fig 3). The first two waves (N115-and P150) probably represent a visual evoked potential (VEP): such a potential was not recorded in the ERPs detected during the verbal tasks in the ANT. The verbal encoding task elicited only a small late potential peaking at about 1sec; no significant ERP was detected in the period typical for cognitive response.


The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study.

Štillová K, Jurák P, Chládek J, Chrastina J, Halámek J, Bočková M, Goldemundová S, Říha I, Rektor I - PLoS ONE (2015)

Visual recognition task in the ANT: N 115- P 150- N 200- P 250 and N700 complex (the mean from all thalamic contacts from all patients in bipolar montage during the recognition task).Arrows mark fast and slow ERP components N115, P150, N200, P250, and N700. The black curve indicates a new stimulus (new picture); red indicates a repeated stimulus during the recognition phase (old picture). On axis x is time (in s). The statistical significance to baseline is highlighted by black and red horizontal lines.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4631321&req=5

pone.0140778.g003: Visual recognition task in the ANT: N 115- P 150- N 200- P 250 and N700 complex (the mean from all thalamic contacts from all patients in bipolar montage during the recognition task).Arrows mark fast and slow ERP components N115, P150, N200, P250, and N700. The black curve indicates a new stimulus (new picture); red indicates a repeated stimulus during the recognition phase (old picture). On axis x is time (in s). The statistical significance to baseline is highlighted by black and red horizontal lines.
Mentions: ERPs elicited by the visual encoding task and the visual and verbal recognition tasks were recorded in the ANT. In the visual encoding and recognition tasks an N 115- P 150- N 200- P 250 and N700 complex was detected (Fig 3). The first two waves (N115-and P150) probably represent a visual evoked potential (VEP): such a potential was not recorded in the ERPs detected during the verbal tasks in the ANT. The verbal encoding task elicited only a small late potential peaking at about 1sec; no significant ERP was detected in the period typical for cognitive response.

Bottom Line: To study the involvement of the anterior nuclei of the thalamus (ANT) as compared to the involvement of the hippocampus in the processes of encoding and recognition during visual and verbal memory tasks.No significant ERPs were recorded during the verbal encoding task in the ANT.ANT is well positioned to serve as a subcortical gate for memory processing in cortical structures.

View Article: PubMed Central - PubMed

Affiliation: Central European Institute of Technology CEITEC, Brain and Mind Research Program, Brno, Czech Republic; Department of Neurology, St. Anne´s Teaching Hospital, Medical School of Masaryk University, Brno, Czech Republic.

ABSTRACT

Objective: To study the involvement of the anterior nuclei of the thalamus (ANT) as compared to the involvement of the hippocampus in the processes of encoding and recognition during visual and verbal memory tasks.

Methods: We studied intracerebral recordings in patients with pharmacoresistent epilepsy who underwent deep brain stimulation (DBS) of the ANT with depth electrodes implanted bilaterally in the ANT and compared the results with epilepsy surgery candidates with depth electrodes implanted bilaterally in the hippocampus. We recorded the event-related potentials (ERPs) elicited by the visual and verbal memory encoding and recognition tasks.

Results: P300-like potentials were recorded in the hippocampus by visual and verbal memory encoding and recognition tasks and in the ANT by the visual encoding and visual and verbal recognition tasks. No significant ERPs were recorded during the verbal encoding task in the ANT. In the visual and verbal recognition tasks, the P300-like potentials in the ANT preceded the P300-like potentials in the hippocampus.

Conclusions: The ANT is a structure in the memory pathway that processes memory information before the hippocampus. We suggest that the ANT has a specific role in memory processes, especially memory recognition, and that memory disturbance should be considered in patients with ANT-DBS and in patients with ANT lesions. ANT is well positioned to serve as a subcortical gate for memory processing in cortical structures.

No MeSH data available.


Related in: MedlinePlus