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Osteosarcoma of the larynx.

Sawicki P, Każmierczak W, Szylberg Ł, Marszałek A - Contemp Oncol (Pozn) (2015)

Bottom Line: Complete laryngectomy was carried out without the surgery of the cervical lymphatic system.The patient remains under the care of the Otolaryngology and Laryngological Oncology Department and Oncology Centre in Bydgoszcz.There were no reports on local recurrence or distant metastases during regular check-ups.

View Article: PubMed Central - PubMed

Affiliation: Chair and Clinic of Otolaryngology and Laryngological Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

ABSTRACT
Malignant neoplasms of the larynx are divided into epithelial and non-epithelial. Non-epithelial neoplasms include, among others, mesenchymal chondrosarcomas and osteosarcomas. Few cases of laryngeal osteosarcomas described in the literature were usually treated by surgery without the need to use adjuvant radio- or chemotherapy. Few authors propose the initial application of radiotherapy or high-dose chemotherapy. Our study presents a very rare case of a woman treated due to laryngeal osteosarcoma. We have also presented diagnostic difficulties preceding a decision to perform radical surgery. The patient had been eligible for radical surgical treatment, even though there were no features of malignancy in a histopathological examination of the biopsy material. Complete laryngectomy was carried out without the surgery of the cervical lymphatic system. Laryngeal osteosarcoma was diagnosed based on the postoperative histopathological examination using vimentin and Ki67. The patient remains under the care of the Otolaryngology and Laryngological Oncology Department and Oncology Centre in Bydgoszcz. There were no reports on local recurrence or distant metastases during regular check-ups.

No MeSH data available.


Related in: MedlinePlus

Microscopic image of osteosarcoma. Analysis of the slides was performed using 200x total magnification (20× objective with 10× oculars). A – the arrows highlight osteosarcoma invasion into cartilage; B – the arrows highlight osteosarcoma invasion into surrounding muscles; C – areas of ossification and deposition of osteoid material; D – positive immunohistochemical staining for vimentin
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Figure 0003: Microscopic image of osteosarcoma. Analysis of the slides was performed using 200x total magnification (20× objective with 10× oculars). A – the arrows highlight osteosarcoma invasion into cartilage; B – the arrows highlight osteosarcoma invasion into surrounding muscles; C – areas of ossification and deposition of osteoid material; D – positive immunohistochemical staining for vimentin

Mentions: A total laryngectomy specimen received after surgery consisted of the tumour 1.5 × 1.5 × 1 cm in size located in the left subglottic area. Grossly, on cross section, the tumour was dark brown and firm with cribriform pattern appearance. Microscopic examination revealed malignant mesenchymal tumour composed of polymorphic cells with hyperchromatic atypical nuclei and small areas of liquefactive tumour necrosis. There was an increased mitotic index. Extensive areas of ossification and deposition of osteoid material with bone formation were observed in different tumour parts (Fig. 3A, B, C). Histological examination also revealed extensive invasion into thyroid cartilage (Fig. 3A) and surrounding soft tissues (Fig. 3B). The tumour was positive for vimentin (Fig. 3D), and Ki-67-positive cells index was approximately 5% on average but focally up to 30%.


Osteosarcoma of the larynx.

Sawicki P, Każmierczak W, Szylberg Ł, Marszałek A - Contemp Oncol (Pozn) (2015)

Microscopic image of osteosarcoma. Analysis of the slides was performed using 200x total magnification (20× objective with 10× oculars). A – the arrows highlight osteosarcoma invasion into cartilage; B – the arrows highlight osteosarcoma invasion into surrounding muscles; C – areas of ossification and deposition of osteoid material; D – positive immunohistochemical staining for vimentin
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4631292&req=5

Figure 0003: Microscopic image of osteosarcoma. Analysis of the slides was performed using 200x total magnification (20× objective with 10× oculars). A – the arrows highlight osteosarcoma invasion into cartilage; B – the arrows highlight osteosarcoma invasion into surrounding muscles; C – areas of ossification and deposition of osteoid material; D – positive immunohistochemical staining for vimentin
Mentions: A total laryngectomy specimen received after surgery consisted of the tumour 1.5 × 1.5 × 1 cm in size located in the left subglottic area. Grossly, on cross section, the tumour was dark brown and firm with cribriform pattern appearance. Microscopic examination revealed malignant mesenchymal tumour composed of polymorphic cells with hyperchromatic atypical nuclei and small areas of liquefactive tumour necrosis. There was an increased mitotic index. Extensive areas of ossification and deposition of osteoid material with bone formation were observed in different tumour parts (Fig. 3A, B, C). Histological examination also revealed extensive invasion into thyroid cartilage (Fig. 3A) and surrounding soft tissues (Fig. 3B). The tumour was positive for vimentin (Fig. 3D), and Ki-67-positive cells index was approximately 5% on average but focally up to 30%.

Bottom Line: Complete laryngectomy was carried out without the surgery of the cervical lymphatic system.The patient remains under the care of the Otolaryngology and Laryngological Oncology Department and Oncology Centre in Bydgoszcz.There were no reports on local recurrence or distant metastases during regular check-ups.

View Article: PubMed Central - PubMed

Affiliation: Chair and Clinic of Otolaryngology and Laryngological Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

ABSTRACT
Malignant neoplasms of the larynx are divided into epithelial and non-epithelial. Non-epithelial neoplasms include, among others, mesenchymal chondrosarcomas and osteosarcomas. Few cases of laryngeal osteosarcomas described in the literature were usually treated by surgery without the need to use adjuvant radio- or chemotherapy. Few authors propose the initial application of radiotherapy or high-dose chemotherapy. Our study presents a very rare case of a woman treated due to laryngeal osteosarcoma. We have also presented diagnostic difficulties preceding a decision to perform radical surgery. The patient had been eligible for radical surgical treatment, even though there were no features of malignancy in a histopathological examination of the biopsy material. Complete laryngectomy was carried out without the surgery of the cervical lymphatic system. Laryngeal osteosarcoma was diagnosed based on the postoperative histopathological examination using vimentin and Ki67. The patient remains under the care of the Otolaryngology and Laryngological Oncology Department and Oncology Centre in Bydgoszcz. There were no reports on local recurrence or distant metastases during regular check-ups.

No MeSH data available.


Related in: MedlinePlus