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Bier spots and unilateral nevoid telangiectasia: more than just a coincidence.

Pinho A, Gouveia M, Oliveira H, Vieira R - An Bras Dermatol (2015)

View Article: PubMed Central - PubMed

Affiliation: Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

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We also observed fine telangiectasia, with the same distribution, both within and outsidethe macular lesions... The telangiectasia did not change according to the position of thelimb... There were no similar skin lesions in any other body areas... Laboratory tests including complete blood count, coagulation studies, cryoglobulins, kidneyand liver function tests, proteinogram, immunoglobulins, sedimentation rate,autoantibodies, thyroid function, sex hormones, urinalysis and serology for HIV andhepatitis were normal, as well as the Doppler ultrasound of the upper limbs... In this case we assumed that the combination between hypochromic lesions compatible withBier spots (BS) and unilateral nevoid telangiectasia (UNT)-like lesions could correspond toa phenomenon of vascular twin spotting, as we will highlight below... Eleven years later, Tan reported the first case of UNT superimposed on BS and consideredthat this dichotomy of vascular phenomena represented a new type of vascular twinspotting... UNT is characterized by unilaterally distributed superficialtelangiectasias of the neck and chest, and indicate persistent vasodilatation... These alleles control the vascular tonus... One isresponsible for vasodilatation and the other is responsible for vasoconstriction... Ifcrossing-over occurs in these chromosomes during mitosis, two distinctclones of homozygous daughter-cells might be generated... The homozygous lineage of thevasoconstriction allele leads to the development of BS, while the homozygous linage of thevasodilatation allele leads to the development of UNT lesions... The unilateral distribution of the lesions, which were located very closely together (andsometimes are superimposed on each other) and shared functional antagonism, led us toconclude that this was a case of vascular twin spotting.

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Dermatoscopic image of telangiectasias superimposed on hypochromic lesions anderythematous skin
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f03: Dermatoscopic image of telangiectasias superimposed on hypochromic lesions anderythematous skin

Mentions: We describe the case of a 12-year-old Caucasian female with numerous macular, ovoid,hypochromic lesions of about 5mm on the dorsum of the left hand and arm. Some of thelesions were confluent, surrounded by erythematous, blanching skin. (Figures 1-3). These lesions wereasymptomatic, began at birth and were induced by pendent position of the arm, disappearinga few seconds after its elevation.


Bier spots and unilateral nevoid telangiectasia: more than just a coincidence.

Pinho A, Gouveia M, Oliveira H, Vieira R - An Bras Dermatol (2015)

Dermatoscopic image of telangiectasias superimposed on hypochromic lesions anderythematous skin
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4631250&req=5

f03: Dermatoscopic image of telangiectasias superimposed on hypochromic lesions anderythematous skin
Mentions: We describe the case of a 12-year-old Caucasian female with numerous macular, ovoid,hypochromic lesions of about 5mm on the dorsum of the left hand and arm. Some of thelesions were confluent, surrounded by erythematous, blanching skin. (Figures 1-3). These lesions wereasymptomatic, began at birth and were induced by pendent position of the arm, disappearinga few seconds after its elevation.

View Article: PubMed Central - PubMed

Affiliation: Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

We also observed fine telangiectasia, with the same distribution, both within and outsidethe macular lesions... The telangiectasia did not change according to the position of thelimb... There were no similar skin lesions in any other body areas... Laboratory tests including complete blood count, coagulation studies, cryoglobulins, kidneyand liver function tests, proteinogram, immunoglobulins, sedimentation rate,autoantibodies, thyroid function, sex hormones, urinalysis and serology for HIV andhepatitis were normal, as well as the Doppler ultrasound of the upper limbs... In this case we assumed that the combination between hypochromic lesions compatible withBier spots (BS) and unilateral nevoid telangiectasia (UNT)-like lesions could correspond toa phenomenon of vascular twin spotting, as we will highlight below... Eleven years later, Tan reported the first case of UNT superimposed on BS and consideredthat this dichotomy of vascular phenomena represented a new type of vascular twinspotting... UNT is characterized by unilaterally distributed superficialtelangiectasias of the neck and chest, and indicate persistent vasodilatation... These alleles control the vascular tonus... One isresponsible for vasodilatation and the other is responsible for vasoconstriction... Ifcrossing-over occurs in these chromosomes during mitosis, two distinctclones of homozygous daughter-cells might be generated... The homozygous lineage of thevasoconstriction allele leads to the development of BS, while the homozygous linage of thevasodilatation allele leads to the development of UNT lesions... The unilateral distribution of the lesions, which were located very closely together (andsometimes are superimposed on each other) and shared functional antagonism, led us toconclude that this was a case of vascular twin spotting.

No MeSH data available.


Related in: MedlinePlus