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Do steroid hormones have an important role on cutaneous lupus physiopathology?

Brasileiro A, Campos S, Fidalgo A - An Bras Dermatol (2015)

View Article: PubMed Central - PubMed

Affiliation: Centro Hospitalar Lisboa Central, Hospital S. António dos Capuchos, Lisbon, Portugal.

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A month later there was pronounced cutaneous worsening and the lesions became refractory to previously effective therapies (Figure efficacy was observed over one-year follow-up despite maintenance of letrozole therapy... significant side effects have occurred... persistence of autoreactive T-cells in SLE patients... is even higher in SLE patients, occurring most commonly in reproductive-age women and being cancer in postmenopausal women... Its anti-oestrogenic effects induce nearly complete Theoretically, aromatase inhibitors should be beneficial in lupus patients, once they reduce cutaneous estradiol production which Conversely, in our patient, letrozole paradoxically Considering that both pathologies are not rare, probably more CLE women will undergo Further studies are warranted to access the effect of aromatase inhibitors in CLE patients.

No MeSH data available.


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A: Multiple well-defined erythematous plaques distributed over convex areas of theface; B: Marked inflammatory infiltration of the scalp with follicular plugging,adherent scale and alopecia
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f01: A: Multiple well-defined erythematous plaques distributed over convex areas of theface; B: Marked inflammatory infiltration of the scalp with follicular plugging,adherent scale and alopecia

Mentions: Four years ago she underwent radical left mastectomy for carcinoma ductal insitu with positive oestrogen receptors, followed by hormonotherapy withletrozole 2,5mg/day. A month later there was pronounced cutaneous worsening and the lesionsbecame refractory to previously effective therapies (Figure1). There were no other recently started medications or systemic complaints;routine blood laboratory tests and autoimmunity antibodies were within normal range.Acitretin 25mg/day was attempted but there was further clinical worsening andimmunosuppressive therapies were contraindicated by the recent malignant neoplasia.Thalidomide 50mg/day was then combined with previous therapies, with marked clinicalimprovement within two weeks, allowing the discontinuation of systemic steroids andhydroxychloroquine (Figure 2). Sustained therapeuticefficacy was observed over one-year follow-up despite maintenance of letrozole therapy. Nosignificant side effects have occurred.


Do steroid hormones have an important role on cutaneous lupus physiopathology?

Brasileiro A, Campos S, Fidalgo A - An Bras Dermatol (2015)

A: Multiple well-defined erythematous plaques distributed over convex areas of theface; B: Marked inflammatory infiltration of the scalp with follicular plugging,adherent scale and alopecia
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4631249&req=5

f01: A: Multiple well-defined erythematous plaques distributed over convex areas of theface; B: Marked inflammatory infiltration of the scalp with follicular plugging,adherent scale and alopecia
Mentions: Four years ago she underwent radical left mastectomy for carcinoma ductal insitu with positive oestrogen receptors, followed by hormonotherapy withletrozole 2,5mg/day. A month later there was pronounced cutaneous worsening and the lesionsbecame refractory to previously effective therapies (Figure1). There were no other recently started medications or systemic complaints;routine blood laboratory tests and autoimmunity antibodies were within normal range.Acitretin 25mg/day was attempted but there was further clinical worsening andimmunosuppressive therapies were contraindicated by the recent malignant neoplasia.Thalidomide 50mg/day was then combined with previous therapies, with marked clinicalimprovement within two weeks, allowing the discontinuation of systemic steroids andhydroxychloroquine (Figure 2). Sustained therapeuticefficacy was observed over one-year follow-up despite maintenance of letrozole therapy. Nosignificant side effects have occurred.

View Article: PubMed Central - PubMed

Affiliation: Centro Hospitalar Lisboa Central, Hospital S. António dos Capuchos, Lisbon, Portugal.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

A month later there was pronounced cutaneous worsening and the lesions became refractory to previously effective therapies (Figure efficacy was observed over one-year follow-up despite maintenance of letrozole therapy... significant side effects have occurred... persistence of autoreactive T-cells in SLE patients... is even higher in SLE patients, occurring most commonly in reproductive-age women and being cancer in postmenopausal women... Its anti-oestrogenic effects induce nearly complete Theoretically, aromatase inhibitors should be beneficial in lupus patients, once they reduce cutaneous estradiol production which Conversely, in our patient, letrozole paradoxically Considering that both pathologies are not rare, probably more CLE women will undergo Further studies are warranted to access the effect of aromatase inhibitors in CLE patients.

No MeSH data available.


Related in: MedlinePlus