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Hypopigmented macules of the limbs in two sisters: report on familial Bier spots.

Stinco G, Errichetti E, Patrone P - An Bras Dermatol (2015)

Bottom Line: AbstractBier spots are asymptomatic, small, irregular, hypopigmented macules characterized by a normal histological appearance, which are usually found on the arms and legs of young adults.We describe the simultaneous presence of Bier spots in two siblings.This finding is unusual since, to the best of our knowledge, concurrent familial cases have never been reported in the literature.

View Article: PubMed Central - PubMed

Affiliation: University of Udine, Udine, Italy.

ABSTRACT
AbstractBier spots are asymptomatic, small, irregular, hypopigmented macules characterized by a normal histological appearance, which are usually found on the arms and legs of young adults. We describe the simultaneous presence of Bier spots in two siblings. This finding is unusual since, to the best of our knowledge, concurrent familial cases have never been reported in the literature.

No MeSH data available.


Related in: MedlinePlus

Hypopigmented macules on the older sibling’s right arm and on her sister’s leftarm.
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f01: Hypopigmented macules on the older sibling’s right arm and on her sister’s leftarm.

Mentions: A 35-year-old female and her 38-year-old sister presented to our department withasymptomatic, small, hypopigmented macules distributed symmetrically on the limbs (Figure 1). In both patients, the spots were visiblewhen extremities were placed in a dependent position and disappeared when limbs wereraised. Lesions started appearing in the older sister around the age of 25, while in theyounger sister, they appeared when she was about 30. There were no mucosal or nailabnormalities and no associations with acrocyanosis or hyperhidrosis. The women had nohistory of vascular disease or other relevant pathological conditions. No other familymember had had similar lesions. Routine laboratory tests yielded normal results. Testsfor cryoglobulin, antiphospholipid antibody, antinuclear antibody, and proteins S and Cwere all negative. On the basis of the characteristic clinical manifestations, Bierspots (BS) were diagnosed. The patients did not receive treatment.


Hypopigmented macules of the limbs in two sisters: report on familial Bier spots.

Stinco G, Errichetti E, Patrone P - An Bras Dermatol (2015)

Hypopigmented macules on the older sibling’s right arm and on her sister’s leftarm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4631241&req=5

f01: Hypopigmented macules on the older sibling’s right arm and on her sister’s leftarm.
Mentions: A 35-year-old female and her 38-year-old sister presented to our department withasymptomatic, small, hypopigmented macules distributed symmetrically on the limbs (Figure 1). In both patients, the spots were visiblewhen extremities were placed in a dependent position and disappeared when limbs wereraised. Lesions started appearing in the older sister around the age of 25, while in theyounger sister, they appeared when she was about 30. There were no mucosal or nailabnormalities and no associations with acrocyanosis or hyperhidrosis. The women had nohistory of vascular disease or other relevant pathological conditions. No other familymember had had similar lesions. Routine laboratory tests yielded normal results. Testsfor cryoglobulin, antiphospholipid antibody, antinuclear antibody, and proteins S and Cwere all negative. On the basis of the characteristic clinical manifestations, Bierspots (BS) were diagnosed. The patients did not receive treatment.

Bottom Line: AbstractBier spots are asymptomatic, small, irregular, hypopigmented macules characterized by a normal histological appearance, which are usually found on the arms and legs of young adults.We describe the simultaneous presence of Bier spots in two siblings.This finding is unusual since, to the best of our knowledge, concurrent familial cases have never been reported in the literature.

View Article: PubMed Central - PubMed

Affiliation: University of Udine, Udine, Italy.

ABSTRACT
AbstractBier spots are asymptomatic, small, irregular, hypopigmented macules characterized by a normal histological appearance, which are usually found on the arms and legs of young adults. We describe the simultaneous presence of Bier spots in two siblings. This finding is unusual since, to the best of our knowledge, concurrent familial cases have never been reported in the literature.

No MeSH data available.


Related in: MedlinePlus