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Patch test results in children and adolescents. Study from the Santa Casa de Belo Horizonte Dermatology Clinic, Brazil, from 2003 to 2010.

Rodrigues DF, Goulart EM - An Bras Dermatol (2015)

Bottom Line: However, there were significant differences regarding sensitization to nickel (p=0.029) and thimerosal (p=0.042) between the two age groups under study, while adolescents were the most affected.Nickel and fragrances were the only positive (and relevant) allergens in children.Nickel and tosylamide formaldehyde resin were the most frequent and relevant allergens among adolescents.

View Article: PubMed Central - PubMed

Affiliation: Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, MG, Brazil.

ABSTRACT

Unlabelled: Abstract

Background: Patch testing is an efficient method to identify the allergen responsible for allergic contact dermatitis.

Objective: To evaluate the results of patch tests in children and adolescents comparing these two age groups' results.

Methods: Cross-sectional study to assess patch test results of 125 children and adolescents aged 1-19 years, with suspected allergic contact dermatitis, in a dermatology clinic in Brazil. Two Brazilian standardized series were used.

Results: Seventy four (59.2%) patients had "at least one positive reaction" to the patch test. Among these positive tests, 77.0% were deemed relevant. The most frequent allergens were nickel (36.8%), thimerosal (18.4%), tosylamide formaldehyde resin (6.8%), neomycin (6.4%), cobalt (4.0%) and fragrance mix I (4.0%). The most frequent positive tests came from adolescents (p=0.0014) and females (p=0.0002). There was no relevant statistical difference concerning contact sensitizations among patients with or without atopic history. However, there were significant differences regarding sensitization to nickel (p=0.029) and thimerosal (p=0.042) between the two age groups under study, while adolescents were the most affected.

Conclusion: Nickel and fragrances were the only positive (and relevant) allergens in children. Nickel and tosylamide formaldehyde resin were the most frequent and relevant allergens among adolescents.

No MeSH data available.


Related in: MedlinePlus

Positive reactions of the most frequent allergens in relation to body locationaffected by dermatitis in the children and adolescents tested (n=74)
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f01: Positive reactions of the most frequent allergens in relation to body locationaffected by dermatitis in the children and adolescents tested (n=74)

Mentions: In patients with positive tests, the head and trunk were the body areas most commonlyaffected by dermatitis. There was a significant difference concerning dermatitislocation in the thighs of patients who had positive tests, with higher positivity inchildren's thighs than in other areas (p=0.0068). Among the most frequent andrelevant allergens, nickel, tosylamide formaldehyde resin and formaldehyde wereparticularly prominent in head involvement; nickel, potassium dichromate and PPD mixsignificantly affected the feet, while nickel and fragrances had clear impacts on theforearms and thighs (Graph 1). Twenty-eightpatients had four or more areas affected, regarded as dermatitisgeneralization,37 out ofwhich 16 had relevant positive tests (12 for nickel), while 3 had irrelevant positivetests and 9 had negative tests.


Patch test results in children and adolescents. Study from the Santa Casa de Belo Horizonte Dermatology Clinic, Brazil, from 2003 to 2010.

Rodrigues DF, Goulart EM - An Bras Dermatol (2015)

Positive reactions of the most frequent allergens in relation to body locationaffected by dermatitis in the children and adolescents tested (n=74)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4631233&req=5

f01: Positive reactions of the most frequent allergens in relation to body locationaffected by dermatitis in the children and adolescents tested (n=74)
Mentions: In patients with positive tests, the head and trunk were the body areas most commonlyaffected by dermatitis. There was a significant difference concerning dermatitislocation in the thighs of patients who had positive tests, with higher positivity inchildren's thighs than in other areas (p=0.0068). Among the most frequent andrelevant allergens, nickel, tosylamide formaldehyde resin and formaldehyde wereparticularly prominent in head involvement; nickel, potassium dichromate and PPD mixsignificantly affected the feet, while nickel and fragrances had clear impacts on theforearms and thighs (Graph 1). Twenty-eightpatients had four or more areas affected, regarded as dermatitisgeneralization,37 out ofwhich 16 had relevant positive tests (12 for nickel), while 3 had irrelevant positivetests and 9 had negative tests.

Bottom Line: However, there were significant differences regarding sensitization to nickel (p=0.029) and thimerosal (p=0.042) between the two age groups under study, while adolescents were the most affected.Nickel and fragrances were the only positive (and relevant) allergens in children.Nickel and tosylamide formaldehyde resin were the most frequent and relevant allergens among adolescents.

View Article: PubMed Central - PubMed

Affiliation: Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, MG, Brazil.

ABSTRACT

Unlabelled: Abstract

Background: Patch testing is an efficient method to identify the allergen responsible for allergic contact dermatitis.

Objective: To evaluate the results of patch tests in children and adolescents comparing these two age groups' results.

Methods: Cross-sectional study to assess patch test results of 125 children and adolescents aged 1-19 years, with suspected allergic contact dermatitis, in a dermatology clinic in Brazil. Two Brazilian standardized series were used.

Results: Seventy four (59.2%) patients had "at least one positive reaction" to the patch test. Among these positive tests, 77.0% were deemed relevant. The most frequent allergens were nickel (36.8%), thimerosal (18.4%), tosylamide formaldehyde resin (6.8%), neomycin (6.4%), cobalt (4.0%) and fragrance mix I (4.0%). The most frequent positive tests came from adolescents (p=0.0014) and females (p=0.0002). There was no relevant statistical difference concerning contact sensitizations among patients with or without atopic history. However, there were significant differences regarding sensitization to nickel (p=0.029) and thimerosal (p=0.042) between the two age groups under study, while adolescents were the most affected.

Conclusion: Nickel and fragrances were the only positive (and relevant) allergens in children. Nickel and tosylamide formaldehyde resin were the most frequent and relevant allergens among adolescents.

No MeSH data available.


Related in: MedlinePlus