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Coccidioidomycosis and the skin: a comprehensive review.

Garcia Garcia SC, Salas Alanis JC, Flores MG, Gonzalez Gonzalez SE, Vera Cabrera L, Ocampo Candiani J - An Bras Dermatol (2015)

Bottom Line: Coccidioides species live in arid and semi-arid regions, causing mainly pulmonary infection through inhalation of arthroconidia although many other organs can be affected.Primary inoculation is rare.Since the first case of coccidioidomycosis was reported in 1892, the skin has been identified as an important target of this disease.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico.

ABSTRACT
AbstractCoccidioidomycosis is a highly prevalent disease in the Western hemisphere. It is considered one of the most virulent primary fungal infections. Coccidioides species live in arid and semi-arid regions, causing mainly pulmonary infection through inhalation of arthroconidia although many other organs can be affected. Primary inoculation is rare. Since the first case of coccidioidomycosis was reported in 1892, the skin has been identified as an important target of this disease. Knowledge of cutaneous clinical forms of this infection is important and very useful for establishing prompt diagnosis and treatment. The purpose of this article is to provide a review of this infection, emphasizing its cutaneous manifestations, diagnostic methods and current treatment.

No MeSH data available.


Related in: MedlinePlus

Biopsy specimen showing a Coccidioides spherule
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f08: Biopsy specimen showing a Coccidioides spherule

Mentions: The skin has been recognized as one of the most common sites of disseminatedcoccidioidomycosis, and it is estimated that 15% to 67% of patients with disseminateddisease have skin involvement.49The clinical appearance of lesions is widely heterogeneous, including papules,nodules, gummas, pustular acneiform lesions, ulcerated and verrucous plaques, scars,abscesses and fistulae (Figures 4-7).5 The usual finding are the nodules.42 The topography involves the face, neck, scalp, andchest wall.5,61 The nasolabial fold is a common site ofinfection.62-64 Facial lesions have been associated with meningitisin some patients.65 Cutaneouslesions typically present within several weeks or months after the primary infection,or they can be the initial manifestation of the disease.53,63 They may besolitary or multiple and are usually asymptomatic.47 Important differential diagnosis includehistoplasmosis, blastomycosis, cryptococcosis, tuberculosis, sarcoidosis and primaryskin malignancies.42 Histopathologyfindings are variable, but usually show suppurative granulomas that containdouble-walled refractile spherules (10 to 80 µm) with endospores (Figure 8).62


Coccidioidomycosis and the skin: a comprehensive review.

Garcia Garcia SC, Salas Alanis JC, Flores MG, Gonzalez Gonzalez SE, Vera Cabrera L, Ocampo Candiani J - An Bras Dermatol (2015)

Biopsy specimen showing a Coccidioides spherule
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4631225&req=5

f08: Biopsy specimen showing a Coccidioides spherule
Mentions: The skin has been recognized as one of the most common sites of disseminatedcoccidioidomycosis, and it is estimated that 15% to 67% of patients with disseminateddisease have skin involvement.49The clinical appearance of lesions is widely heterogeneous, including papules,nodules, gummas, pustular acneiform lesions, ulcerated and verrucous plaques, scars,abscesses and fistulae (Figures 4-7).5 The usual finding are the nodules.42 The topography involves the face, neck, scalp, andchest wall.5,61 The nasolabial fold is a common site ofinfection.62-64 Facial lesions have been associated with meningitisin some patients.65 Cutaneouslesions typically present within several weeks or months after the primary infection,or they can be the initial manifestation of the disease.53,63 They may besolitary or multiple and are usually asymptomatic.47 Important differential diagnosis includehistoplasmosis, blastomycosis, cryptococcosis, tuberculosis, sarcoidosis and primaryskin malignancies.42 Histopathologyfindings are variable, but usually show suppurative granulomas that containdouble-walled refractile spherules (10 to 80 µm) with endospores (Figure 8).62

Bottom Line: Coccidioides species live in arid and semi-arid regions, causing mainly pulmonary infection through inhalation of arthroconidia although many other organs can be affected.Primary inoculation is rare.Since the first case of coccidioidomycosis was reported in 1892, the skin has been identified as an important target of this disease.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico.

ABSTRACT
AbstractCoccidioidomycosis is a highly prevalent disease in the Western hemisphere. It is considered one of the most virulent primary fungal infections. Coccidioides species live in arid and semi-arid regions, causing mainly pulmonary infection through inhalation of arthroconidia although many other organs can be affected. Primary inoculation is rare. Since the first case of coccidioidomycosis was reported in 1892, the skin has been identified as an important target of this disease. Knowledge of cutaneous clinical forms of this infection is important and very useful for establishing prompt diagnosis and treatment. The purpose of this article is to provide a review of this infection, emphasizing its cutaneous manifestations, diagnostic methods and current treatment.

No MeSH data available.


Related in: MedlinePlus