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Patterns of HIV viremia and viral suppression before diagnosis of non-AIDS-defining cancers in HIV-infected individuals.

Riedel DJ, Rositch AF, Redfield RR - Infect. Agents Cancer (2015)

Bottom Line: The most common NADC's were lung (n = 60), prostate (n = 47), oropharyngeal (n = 32), liver (n = 29), and anal cancer (n = 20) and Hodgkin lymphoma (n = 18).Patients with oropharyngeal (70 %) and prostate cancer (78 %) had a higher proportion of visits with suppressed viral loads.In this cohort of HIV-infected patients diagnosed with NADCs, there were important differences in the patterns and levels of viremia between the different NADCs in the ten years prior to cancer diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Institute of Human Virology and Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, MD USA ; Institute of Human Virology and Division of Infectious Diseases, University of Maryland School of Medicine, Program in Oncology, University of Maryland Marlene and Stewart Greenebaum Cancer Center, 725 W. Lombard St., N552, Baltimore, MD 21201 USA.

ABSTRACT

Background: The association between HIV viremia and non-AIDS-defining cancers (NADCs) is not well characterized. Viremia may contribute directly or indirectly to cancer development and may have a differential impact on various cancer types. Our objective was to characterize patterns of HIV viremia in a retrospective, urban, clinical cohort (N = 320) of patients diagnosed with NADCs.

Findings: The most common NADC's were lung (n = 60), prostate (n = 47), oropharyngeal (n = 32), liver (n = 29), and anal cancer (n = 20) and Hodgkin lymphoma (n = 18). In the year before cancer diagnosis, 66 % of all patients were virally suppressed. Patients with oropharyngeal (70 %) and prostate cancer (78 %) had a higher proportion of visits with suppressed viral loads. Patients diagnosed with anal cancer and Hodgkin lymphoma were infrequently virally suppressed and more frequently had viral loads ≥5 log10 copies/ml in the ten years prior to cancer diagnosis.

Conclusions: In this cohort of HIV-infected patients diagnosed with NADCs, there were important differences in the patterns and levels of viremia between the different NADCs in the ten years prior to cancer diagnosis. Patients with anal cancer and Hodgkin lymphoma had the highest proportion of high level viremia in the ten years before cancer and the lowest frequency of viral load suppression at cancer diagnosis.

No MeSH data available.


Related in: MedlinePlus

Patterns of log10 HIV RNA viral load prior to cancer diagnosis for the six most common NADCs (a) and for NADCs versus ADCs (b)
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Fig1: Patterns of log10 HIV RNA viral load prior to cancer diagnosis for the six most common NADCs (a) and for NADCs versus ADCs (b)

Mentions: The linear pattern of the individual log10 VL measurements across time before cancer diagnosis for the six NADCs is shown in Fig. 1a. The slope of viremia curves for both Hodgkin lymphoma and anal cancer were negative, while curves for the other four NADCs were comparatively flat. Figure 1b shows the pattern of VL across time for NADCs compared to ADCs. When further examining the level of VL among all patients with NADCs, only 6.6 % of visits in the ten years before diagnosis had very high VL (e.g. log10 VL ≥5). Patients with anal cancer (19.4 %) and Hodgkin lymphoma (17.5 %) had the highest frequency of ≥5 log10 VL measurements, while those with prostate (2.7 %), liver (3.6 %), lung (5.1 %), and oropharyngeal (6.9 %) cancers had the fewest.Fig. 1


Patterns of HIV viremia and viral suppression before diagnosis of non-AIDS-defining cancers in HIV-infected individuals.

Riedel DJ, Rositch AF, Redfield RR - Infect. Agents Cancer (2015)

Patterns of log10 HIV RNA viral load prior to cancer diagnosis for the six most common NADCs (a) and for NADCs versus ADCs (b)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4631102&req=5

Fig1: Patterns of log10 HIV RNA viral load prior to cancer diagnosis for the six most common NADCs (a) and for NADCs versus ADCs (b)
Mentions: The linear pattern of the individual log10 VL measurements across time before cancer diagnosis for the six NADCs is shown in Fig. 1a. The slope of viremia curves for both Hodgkin lymphoma and anal cancer were negative, while curves for the other four NADCs were comparatively flat. Figure 1b shows the pattern of VL across time for NADCs compared to ADCs. When further examining the level of VL among all patients with NADCs, only 6.6 % of visits in the ten years before diagnosis had very high VL (e.g. log10 VL ≥5). Patients with anal cancer (19.4 %) and Hodgkin lymphoma (17.5 %) had the highest frequency of ≥5 log10 VL measurements, while those with prostate (2.7 %), liver (3.6 %), lung (5.1 %), and oropharyngeal (6.9 %) cancers had the fewest.Fig. 1

Bottom Line: The most common NADC's were lung (n = 60), prostate (n = 47), oropharyngeal (n = 32), liver (n = 29), and anal cancer (n = 20) and Hodgkin lymphoma (n = 18).Patients with oropharyngeal (70 %) and prostate cancer (78 %) had a higher proportion of visits with suppressed viral loads.In this cohort of HIV-infected patients diagnosed with NADCs, there were important differences in the patterns and levels of viremia between the different NADCs in the ten years prior to cancer diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Institute of Human Virology and Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, MD USA ; Institute of Human Virology and Division of Infectious Diseases, University of Maryland School of Medicine, Program in Oncology, University of Maryland Marlene and Stewart Greenebaum Cancer Center, 725 W. Lombard St., N552, Baltimore, MD 21201 USA.

ABSTRACT

Background: The association between HIV viremia and non-AIDS-defining cancers (NADCs) is not well characterized. Viremia may contribute directly or indirectly to cancer development and may have a differential impact on various cancer types. Our objective was to characterize patterns of HIV viremia in a retrospective, urban, clinical cohort (N = 320) of patients diagnosed with NADCs.

Findings: The most common NADC's were lung (n = 60), prostate (n = 47), oropharyngeal (n = 32), liver (n = 29), and anal cancer (n = 20) and Hodgkin lymphoma (n = 18). In the year before cancer diagnosis, 66 % of all patients were virally suppressed. Patients with oropharyngeal (70 %) and prostate cancer (78 %) had a higher proportion of visits with suppressed viral loads. Patients diagnosed with anal cancer and Hodgkin lymphoma were infrequently virally suppressed and more frequently had viral loads ≥5 log10 copies/ml in the ten years prior to cancer diagnosis.

Conclusions: In this cohort of HIV-infected patients diagnosed with NADCs, there were important differences in the patterns and levels of viremia between the different NADCs in the ten years prior to cancer diagnosis. Patients with anal cancer and Hodgkin lymphoma had the highest proportion of high level viremia in the ten years before cancer and the lowest frequency of viral load suppression at cancer diagnosis.

No MeSH data available.


Related in: MedlinePlus