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Detailed Anatomical and Electrophysiological Models of Human Atria and Torso for the Simulation of Atrial Activation.

Ferrer A, Sebastián R, Sánchez-Quintana D, Rodríguez JF, Godoy EJ, Martínez L, Saiz J - PLoS ONE (2015)

Bottom Line: In recent years both P-waves and the BSPM have been used to identify the mechanisms underlying AF, such as localizing ectopic foci or high-frequency rotors.However, the relationship between the activation of the different areas of the atria and the characteristics of the BSPM and P-wave signals are still far from being completely understood.Using this multi scale model, it was revealed that the best places for recording P-waves are the frontal upper right and the frontal and rear left quadrants of the torso.

View Article: PubMed Central - PubMed

Affiliation: Centro de Investigación e Innovación en Bioingeniería (Ci2B), Universitat Politècnica de València, Valencia, Spain.

ABSTRACT
Atrial arrhythmias, and specifically atrial fibrillation (AF), induce rapid and irregular activation patterns that appear on the torso surface as abnormal P-waves in electrocardiograms and body surface potential maps (BSPM). In recent years both P-waves and the BSPM have been used to identify the mechanisms underlying AF, such as localizing ectopic foci or high-frequency rotors. However, the relationship between the activation of the different areas of the atria and the characteristics of the BSPM and P-wave signals are still far from being completely understood. In this work we developed a multi-scale framework, which combines a highly-detailed 3D atrial model and a torso model to study the relationship between atrial activation and surface signals in sinus rhythm. Using this multi scale model, it was revealed that the best places for recording P-waves are the frontal upper right and the frontal and rear left quadrants of the torso. Our results also suggest that only nine regions (of the twenty-one structures in which the atrial surface was divided) make a significant contribution to the BSPM and determine the main P-wave characteristics.

No MeSH data available.


Related in: MedlinePlus

Atrial action potential (AP) morphology and duration.a) APD90 (ms) measured in each node of the atria at the tenth beat; b) mean and standard deviation of the APD90 (ms) for each region; AP (mV) registered at one random node from c) each structure of RA, and d) each structure of LA.
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pone.0141573.g005: Atrial action potential (AP) morphology and duration.a) APD90 (ms) measured in each node of the atria at the tenth beat; b) mean and standard deviation of the APD90 (ms) for each region; AP (mV) registered at one random node from c) each structure of RA, and d) each structure of LA.

Mentions: The eight stabilized cellular models (see Methods) were coupled into the 3D atrial model. Next, 10 additional stimuli with a frequency of 1 Hz, amplitude of 30 pA/pF and duration of 2 ms were applied to the SAN region to reach the steady-state in 3D and smooth differences between neighbouring regions. Fig 5a shows the spatial variability of APD90, which ranges from the lowest values at the PVs (153 ms) to the highest at the BB (235 ms). Fig 5b shows the mean APD90 and first standard deviation (σ) for each atrial region where minimum mean values correspond to the PVs (178.9±8.2 ms), whereas maximum mean values are from the BB (222.4±4.3 ms). Dispersion within each region ranges from σ = ±9.3 ms (CT) to σ = ±4.3 ms (BB). The relationship between APDs in each region at organ scale (Fig 5c and 5d) was maintained when compared to 0D, although a smoothing effect was observed due to coupling as expected (Fig 3a).


Detailed Anatomical and Electrophysiological Models of Human Atria and Torso for the Simulation of Atrial Activation.

Ferrer A, Sebastián R, Sánchez-Quintana D, Rodríguez JF, Godoy EJ, Martínez L, Saiz J - PLoS ONE (2015)

Atrial action potential (AP) morphology and duration.a) APD90 (ms) measured in each node of the atria at the tenth beat; b) mean and standard deviation of the APD90 (ms) for each region; AP (mV) registered at one random node from c) each structure of RA, and d) each structure of LA.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4629897&req=5

pone.0141573.g005: Atrial action potential (AP) morphology and duration.a) APD90 (ms) measured in each node of the atria at the tenth beat; b) mean and standard deviation of the APD90 (ms) for each region; AP (mV) registered at one random node from c) each structure of RA, and d) each structure of LA.
Mentions: The eight stabilized cellular models (see Methods) were coupled into the 3D atrial model. Next, 10 additional stimuli with a frequency of 1 Hz, amplitude of 30 pA/pF and duration of 2 ms were applied to the SAN region to reach the steady-state in 3D and smooth differences between neighbouring regions. Fig 5a shows the spatial variability of APD90, which ranges from the lowest values at the PVs (153 ms) to the highest at the BB (235 ms). Fig 5b shows the mean APD90 and first standard deviation (σ) for each atrial region where minimum mean values correspond to the PVs (178.9±8.2 ms), whereas maximum mean values are from the BB (222.4±4.3 ms). Dispersion within each region ranges from σ = ±9.3 ms (CT) to σ = ±4.3 ms (BB). The relationship between APDs in each region at organ scale (Fig 5c and 5d) was maintained when compared to 0D, although a smoothing effect was observed due to coupling as expected (Fig 3a).

Bottom Line: In recent years both P-waves and the BSPM have been used to identify the mechanisms underlying AF, such as localizing ectopic foci or high-frequency rotors.However, the relationship between the activation of the different areas of the atria and the characteristics of the BSPM and P-wave signals are still far from being completely understood.Using this multi scale model, it was revealed that the best places for recording P-waves are the frontal upper right and the frontal and rear left quadrants of the torso.

View Article: PubMed Central - PubMed

Affiliation: Centro de Investigación e Innovación en Bioingeniería (Ci2B), Universitat Politècnica de València, Valencia, Spain.

ABSTRACT
Atrial arrhythmias, and specifically atrial fibrillation (AF), induce rapid and irregular activation patterns that appear on the torso surface as abnormal P-waves in electrocardiograms and body surface potential maps (BSPM). In recent years both P-waves and the BSPM have been used to identify the mechanisms underlying AF, such as localizing ectopic foci or high-frequency rotors. However, the relationship between the activation of the different areas of the atria and the characteristics of the BSPM and P-wave signals are still far from being completely understood. In this work we developed a multi-scale framework, which combines a highly-detailed 3D atrial model and a torso model to study the relationship between atrial activation and surface signals in sinus rhythm. Using this multi scale model, it was revealed that the best places for recording P-waves are the frontal upper right and the frontal and rear left quadrants of the torso. Our results also suggest that only nine regions (of the twenty-one structures in which the atrial surface was divided) make a significant contribution to the BSPM and determine the main P-wave characteristics.

No MeSH data available.


Related in: MedlinePlus