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Meta-analysis of routine blood tests as predictors of mortality in COPD.

Lomholt FK, Laulund AS, Bjarnason NH, Jørgensen HL, Godtfredsen NS - Eur Clin Respir J (2014)

Bottom Line: Pooled odds ratios (ORs), matching 95% confidence intervals (CIs), and p-values for each of the biochemical markers were calculated using the random effect model.The following four examined biochemical markers were shown to be associated with mortality in patients suffering from COPD: anemia (OR=2.62, 95% CI: 1.60; 4.29, p=0.01), hypoalbuminemia (OR=2.90, 95% CI: 1.56; 5.40, p=0.0008), elevated NT-proBNP (OR=7.54, 95% CI: 4.04; 14.10, p<0.00001), and elevated cardiac troponin T (OR=3.10, 95% CI: 1.11; 8.25, p=0.03). hs-CRP was not found to be associated with increased mortality.In this study, we found that anemia, hypoalbuminemia, elevated NT-proBNP, and elevated cardiac troponin T were associated with increased mortality in patients suffering from COPD.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Biochemistry, Bispebjerg University Hospital, Copenhagen, Denmark.

ABSTRACT

Objective: The purpose of this study was to examine whether routine blood tests can be useful in predicting mortality in COPD patients.

Methods: Eligible studies were found through a search conducted in the PubMed and Embase databases, the Cochrane Library, and the Web of Knowledge. Twelve studies were included for the meta-analysis of five biochemical markers. Pooled odds ratios (ORs), matching 95% confidence intervals (CIs), and p-values for each of the biochemical markers were calculated using the random effect model.

Results: The following four examined biochemical markers were shown to be associated with mortality in patients suffering from COPD: anemia (OR=2.62, 95% CI: 1.60; 4.29, p=0.01), hypoalbuminemia (OR=2.90, 95% CI: 1.56; 5.40, p=0.0008), elevated NT-proBNP (OR=7.54, 95% CI: 4.04; 14.10, p<0.00001), and elevated cardiac troponin T (OR=3.10, 95% CI: 1.11; 8.25, p=0.03). hs-CRP was not found to be associated with increased mortality.

Conclusion: In this study, we found that anemia, hypoalbuminemia, elevated NT-proBNP, and elevated cardiac troponin T were associated with increased mortality in patients suffering from COPD.

No MeSH data available.


Related in: MedlinePlus

Odds ratios for mortality in patients with anemia versus patients with normal hemoglobin levels.
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Figure 0002: Odds ratios for mortality in patients with anemia versus patients with normal hemoglobin levels.

Mentions: The studies included on NT-proBNP and albumin showed a high level of similarity (I2=0%), whereas the studies included on anemia, hs-CRP, and cardiac troponin T showed higher levels of dissimilarity (I2>50%).


Meta-analysis of routine blood tests as predictors of mortality in COPD.

Lomholt FK, Laulund AS, Bjarnason NH, Jørgensen HL, Godtfredsen NS - Eur Clin Respir J (2014)

Odds ratios for mortality in patients with anemia versus patients with normal hemoglobin levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4629760&req=5

Figure 0002: Odds ratios for mortality in patients with anemia versus patients with normal hemoglobin levels.
Mentions: The studies included on NT-proBNP and albumin showed a high level of similarity (I2=0%), whereas the studies included on anemia, hs-CRP, and cardiac troponin T showed higher levels of dissimilarity (I2>50%).

Bottom Line: Pooled odds ratios (ORs), matching 95% confidence intervals (CIs), and p-values for each of the biochemical markers were calculated using the random effect model.The following four examined biochemical markers were shown to be associated with mortality in patients suffering from COPD: anemia (OR=2.62, 95% CI: 1.60; 4.29, p=0.01), hypoalbuminemia (OR=2.90, 95% CI: 1.56; 5.40, p=0.0008), elevated NT-proBNP (OR=7.54, 95% CI: 4.04; 14.10, p<0.00001), and elevated cardiac troponin T (OR=3.10, 95% CI: 1.11; 8.25, p=0.03). hs-CRP was not found to be associated with increased mortality.In this study, we found that anemia, hypoalbuminemia, elevated NT-proBNP, and elevated cardiac troponin T were associated with increased mortality in patients suffering from COPD.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Biochemistry, Bispebjerg University Hospital, Copenhagen, Denmark.

ABSTRACT

Objective: The purpose of this study was to examine whether routine blood tests can be useful in predicting mortality in COPD patients.

Methods: Eligible studies were found through a search conducted in the PubMed and Embase databases, the Cochrane Library, and the Web of Knowledge. Twelve studies were included for the meta-analysis of five biochemical markers. Pooled odds ratios (ORs), matching 95% confidence intervals (CIs), and p-values for each of the biochemical markers were calculated using the random effect model.

Results: The following four examined biochemical markers were shown to be associated with mortality in patients suffering from COPD: anemia (OR=2.62, 95% CI: 1.60; 4.29, p=0.01), hypoalbuminemia (OR=2.90, 95% CI: 1.56; 5.40, p=0.0008), elevated NT-proBNP (OR=7.54, 95% CI: 4.04; 14.10, p<0.00001), and elevated cardiac troponin T (OR=3.10, 95% CI: 1.11; 8.25, p=0.03). hs-CRP was not found to be associated with increased mortality.

Conclusion: In this study, we found that anemia, hypoalbuminemia, elevated NT-proBNP, and elevated cardiac troponin T were associated with increased mortality in patients suffering from COPD.

No MeSH data available.


Related in: MedlinePlus