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Inflammatory myofibroblastic tumor: a rare tumor of the lung.

İçmeli ÖS, Alpay LA, Gündoğuş B, Türker H, Şen A - Eur Clin Respir J (2014)

Bottom Line: IMT is a rare benign tumor.The diagnosis is difficult to make before surgery since its clinical and radiological features are variable and nonspecific.Although it is a benign lesion, it should be completely resected and patients should be closely monitored following the resection in order to avoid local invasion and recurrence.

View Article: PubMed Central - PubMed

Affiliation: Süreyyapasa Chest Diseases and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey.

ABSTRACT
Inflammatory myofibroblastic tumor (IMT) is a rare lesion, representing 0.04-1.2% of all lung tumors. Brunn first described it in 1939, but its etiology remains uncertain. A 16-year-old patient was admitted to our hospital for further examination following abnormal radiological findings. The physical examination showed no abnormality, and routine hematological and biochemical parameters were within normal range. Chest radiograph revealed homogenous opacity of the right upper lobe with regular margins. Thoracic CT showed a nodular lesion, 30×26 mm in dimensions, with lobular contours in the right hilar. Bronchoscopic examination showed a vascular endobronchial lesion in the anterior right upper lobe, with bleeding when palpated. She underwent right thoracotomy for diagnostic and therapeutic purposes since bronchoscopic biopsy failed because of bleeding. With a pathological diagnosis of IMT, the present report discusses her case accompanied by relevant literature as it is a very rare type of lung tumor. IMT is a rare benign tumor. The diagnosis is difficult to make before surgery since its clinical and radiological features are variable and nonspecific. Although it is a benign lesion, it should be completely resected and patients should be closely monitored following the resection in order to avoid local invasion and recurrence.

No MeSH data available.


Related in: MedlinePlus

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Figure 0004: Postop radiograph.

Mentions: The physical examination showed no abnormality, and routine hematological and biochemical parameters were within normal range. Chest radiograph revealed homogenous opacity of the right upper lobe with regular margins (Fig. 1). Thoracic CT showed a nodular lesion, 30×26 mm in dimensions, with lobular contours in the right hilar (Fig. 2). Bronchoscopic examination showed a vascular endobronchial lesion in the anterior right upper lobe, with bleeding when palpated (Fig. 3). She underwent right thoracotomy for diagnostic and therapeutic purposes since bronchoscopic biopsy failed because of bleeding. A right upper lobectomy was performed since the mass in the right upper lobe could only have been removed by lobectomy. A dirty white matter with a hemorrhagic center, measuring 4 cm in diameter, was observed macroscopically in the lobectomy material. Microscopic examination revealed formation of lymphoid aggregates with plenty of cells and plasma cells having an oval to fusiform and histiocytic appearance, which resulted in bundles and nodular clusters in patches. Immunohistochemical staining was negative for ALK and FL1-1, and positive for vimentin. The pathological diagnosis was reported as atypical IMT. The patient has no current complaint, and a postoperative chest radiograph showed no lesion (Fig. 4).


Inflammatory myofibroblastic tumor: a rare tumor of the lung.

İçmeli ÖS, Alpay LA, Gündoğuş B, Türker H, Şen A - Eur Clin Respir J (2014)

Postop radiograph.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4629718&req=5

Figure 0004: Postop radiograph.
Mentions: The physical examination showed no abnormality, and routine hematological and biochemical parameters were within normal range. Chest radiograph revealed homogenous opacity of the right upper lobe with regular margins (Fig. 1). Thoracic CT showed a nodular lesion, 30×26 mm in dimensions, with lobular contours in the right hilar (Fig. 2). Bronchoscopic examination showed a vascular endobronchial lesion in the anterior right upper lobe, with bleeding when palpated (Fig. 3). She underwent right thoracotomy for diagnostic and therapeutic purposes since bronchoscopic biopsy failed because of bleeding. A right upper lobectomy was performed since the mass in the right upper lobe could only have been removed by lobectomy. A dirty white matter with a hemorrhagic center, measuring 4 cm in diameter, was observed macroscopically in the lobectomy material. Microscopic examination revealed formation of lymphoid aggregates with plenty of cells and plasma cells having an oval to fusiform and histiocytic appearance, which resulted in bundles and nodular clusters in patches. Immunohistochemical staining was negative for ALK and FL1-1, and positive for vimentin. The pathological diagnosis was reported as atypical IMT. The patient has no current complaint, and a postoperative chest radiograph showed no lesion (Fig. 4).

Bottom Line: IMT is a rare benign tumor.The diagnosis is difficult to make before surgery since its clinical and radiological features are variable and nonspecific.Although it is a benign lesion, it should be completely resected and patients should be closely monitored following the resection in order to avoid local invasion and recurrence.

View Article: PubMed Central - PubMed

Affiliation: Süreyyapasa Chest Diseases and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey.

ABSTRACT
Inflammatory myofibroblastic tumor (IMT) is a rare lesion, representing 0.04-1.2% of all lung tumors. Brunn first described it in 1939, but its etiology remains uncertain. A 16-year-old patient was admitted to our hospital for further examination following abnormal radiological findings. The physical examination showed no abnormality, and routine hematological and biochemical parameters were within normal range. Chest radiograph revealed homogenous opacity of the right upper lobe with regular margins. Thoracic CT showed a nodular lesion, 30×26 mm in dimensions, with lobular contours in the right hilar. Bronchoscopic examination showed a vascular endobronchial lesion in the anterior right upper lobe, with bleeding when palpated. She underwent right thoracotomy for diagnostic and therapeutic purposes since bronchoscopic biopsy failed because of bleeding. With a pathological diagnosis of IMT, the present report discusses her case accompanied by relevant literature as it is a very rare type of lung tumor. IMT is a rare benign tumor. The diagnosis is difficult to make before surgery since its clinical and radiological features are variable and nonspecific. Although it is a benign lesion, it should be completely resected and patients should be closely monitored following the resection in order to avoid local invasion and recurrence.

No MeSH data available.


Related in: MedlinePlus